Human Papillomavirus-Negative Cervical Cancer: A Comprehensive Review
Human papillomavirus (HPV) has been the leading cause of cervical cancer for over 25 years. Approximately 5.5–11% of all cervical cancers are reported to be HPV-negative, which can be attributed to truly negative and false-negative results. The truly HPV-negative cervical cancers are almost all cerv...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.606335/full |
| _version_ | 1818949953725136896 |
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| author | Biyuan Xing Jianfeng Guo Yuhan Sheng Gang Wu Yingchao Zhao |
| author_facet | Biyuan Xing Jianfeng Guo Yuhan Sheng Gang Wu Yingchao Zhao |
| author_sort | Biyuan Xing |
| collection | DOAJ |
| description | Human papillomavirus (HPV) has been the leading cause of cervical cancer for over 25 years. Approximately 5.5–11% of all cervical cancers are reported to be HPV-negative, which can be attributed to truly negative and false-negative results. The truly HPV-negative cervical cancers are almost all cervical adenocarcinomas with unclear etiology. False HPV negativity can arise from histological misclassification, latent HPV infection, disruption of the targeting fragment, non-high risk HPV infection, and HPV testing methods. HPV-negative cervical cancers are often diagnosed at an advanced FIGO stage and have a poor prognosis; thus, the management of these cases requires greater attention. |
| first_indexed | 2024-12-20T09:10:53Z |
| format | Article |
| id | doaj.art-4c9c2921f61b4a0aa3696e74aa718f7a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-20T09:10:53Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4c9c2921f61b4a0aa3696e74aa718f7a2022-12-21T19:45:34ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-02-011010.3389/fonc.2020.606335606335Human Papillomavirus-Negative Cervical Cancer: A Comprehensive ReviewBiyuan Xing0Jianfeng Guo1Yuhan Sheng2Gang Wu3Yingchao Zhao4Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHuman papillomavirus (HPV) has been the leading cause of cervical cancer for over 25 years. Approximately 5.5–11% of all cervical cancers are reported to be HPV-negative, which can be attributed to truly negative and false-negative results. The truly HPV-negative cervical cancers are almost all cervical adenocarcinomas with unclear etiology. False HPV negativity can arise from histological misclassification, latent HPV infection, disruption of the targeting fragment, non-high risk HPV infection, and HPV testing methods. HPV-negative cervical cancers are often diagnosed at an advanced FIGO stage and have a poor prognosis; thus, the management of these cases requires greater attention.https://www.frontiersin.org/articles/10.3389/fonc.2020.606335/fullhuman papillomavirushuman papillomavirus (HPV) testingfalse-negativehuman papillomavirus (HPV)-negativecervical cancer |
| spellingShingle | Biyuan Xing Jianfeng Guo Yuhan Sheng Gang Wu Yingchao Zhao Human Papillomavirus-Negative Cervical Cancer: A Comprehensive Review Frontiers in Oncology human papillomavirus human papillomavirus (HPV) testing false-negative human papillomavirus (HPV)-negative cervical cancer |
| title | Human Papillomavirus-Negative Cervical Cancer: A Comprehensive Review |
| title_full | Human Papillomavirus-Negative Cervical Cancer: A Comprehensive Review |
| title_fullStr | Human Papillomavirus-Negative Cervical Cancer: A Comprehensive Review |
| title_full_unstemmed | Human Papillomavirus-Negative Cervical Cancer: A Comprehensive Review |
| title_short | Human Papillomavirus-Negative Cervical Cancer: A Comprehensive Review |
| title_sort | human papillomavirus negative cervical cancer a comprehensive review |
| topic | human papillomavirus human papillomavirus (HPV) testing false-negative human papillomavirus (HPV)-negative cervical cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.606335/full |
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