Heart Rate Reduction With Ivabradine Protects Against Left Ventricular Remodeling by Attenuating Infarct Expansion and Preserving Remote‐Zone Contractile Function and Synchrony in a Mouse Model of Reperfused Myocardial Infarction

Heart Rate Reduction With Ivabradine Protects Against Left Ventricular Remodeling by Attenuating Infarct Expansion and Preserving Remote‐Zone Contractile Function and Synchrony in a Mouse Model of Reperfused Myocardial Infarction

BackgroundIvabradine selectively inhibits the pacemaker current of the sinoatrial node, slowing heart rate. Few studies have examined the effects of ivabradine on the mechanical properties of the heart after reperfused myocardial infarction (MI). Advances in ultrasound speckle‐tracking allow strain...

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Bibliographic Details
Main Authors: Daniel M. O'Connor, Robert S. Smith, Bryan A. Piras, Ronald J. Beyers, Dan Lin, John A. Hossack, Brent A. French
Format: Article
Language:English
Published: Wiley 2016-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
dyssynchrony
heart rate
ivabradine
left ventricular remodeling
speckle‐tracking echocardiography
strain rate imaging
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.115.002989

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