Impact of brown adipose tissue vascular density on body adiposity in healthy Japanese infants and children
Abstract Background and Objective The importance of brown adipose tissue (BAT) is well recognized in healthy infants and children. However, information regarding age‐related changes in BAT vascular density (BAT‐d) and the impact of BAT‐d on body adiposity are lacking. This study aimed to evaluate th...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-04-01
|
| Series: | Obesity Science & Practice |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/osp4.559 |
| _version_ | 1823991492736188416 |
|---|---|
| author | Miyuki Kuroiwa Sayuri Hamaoka‐Fuse Shiho Amagasa Ryotaro Kime Tasuki Endo Riki Tanaka Yuko Kurosawa Takafumi Hamaoka |
| author_facet | Miyuki Kuroiwa Sayuri Hamaoka‐Fuse Shiho Amagasa Ryotaro Kime Tasuki Endo Riki Tanaka Yuko Kurosawa Takafumi Hamaoka |
| author_sort | Miyuki Kuroiwa |
| collection | DOAJ |
| description | Abstract Background and Objective The importance of brown adipose tissue (BAT) is well recognized in healthy infants and children. However, information regarding age‐related changes in BAT vascular density (BAT‐d) and the impact of BAT‐d on body adiposity are lacking. This study aimed to evaluate the normal values of BAT‐d, factors influencing BAT‐d, and the impact of BAT‐d on body adiposity in healthy infants and children. Methods This study included 240 participants (127 girls and 113 boys) aged 1 month to 5 years. The tissue total hemoglobin concentration in the supraclavicular region adjusted according to the subcutaneous adipose tissue thickness (SAT) ([total‐Hb‐Adj]sup) as BAT‐d. SAT in the deltoid and interscapular regions (SATdel+int), the Kaup index (body weight [g]/height or length [cm]/height or length [cm] × 10) as body adiposity, and fertilization season were also measured. Results The [total‐Hb‐Adj]sup of boys was higher than that of girls (r = 0.277, p = 0.009). Younger children had a significantly higher Kaup index (r = 0.495, p < 0.001) and SATdel+int (r = 0.614, p < 0.001) than older children. Children who had higher [total‐Hb‐Adj]sup had a significantly lower Kaup index (r = 0.495, p = 0.037) and SATdel+int (r = 0.614, p < 0.001). Conclusion The [total‐Hb‐Adj]sup, as a parameter of BAT‐d, is negatively correlated with body adiposity in children aged 1 month to 5 years, and BAT might affect human obesity to a much greater extent than expected. To prevent or treat obesity in early childhood, the level of BAT‐d should be considered when using a dietary intervention. |
| first_indexed | 2024-12-18T15:54:44Z |
| format | Article |
| id | doaj.art-4ca093c1896a4d14bc429c6d5a823ad4 |
| institution | Directory Open Access Journal |
| issn | 2055-2238 |
| language | English |
| last_indexed | 2024-12-18T15:54:44Z |
| publishDate | 2022-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obesity Science & Practice |
| spelling | doaj.art-4ca093c1896a4d14bc429c6d5a823ad42022-12-21T21:02:30ZengWileyObesity Science & Practice2055-22382022-04-018219019810.1002/osp4.559Impact of brown adipose tissue vascular density on body adiposity in healthy Japanese infants and childrenMiyuki Kuroiwa0Sayuri Hamaoka‐Fuse1Shiho Amagasa2Ryotaro Kime3Tasuki Endo4Riki Tanaka5Yuko Kurosawa6Takafumi Hamaoka7Department of Sports Medicine for Health Promotion Tokyo Medical University Tokyo JapanDepartment of Sports Medicine for Health Promotion Tokyo Medical University Tokyo JapanDepartment of Preventive Medicine and Public Health Tokyo Medical University Tokyo JapanDepartment of Sports Medicine for Health Promotion Tokyo Medical University Tokyo JapanDepartment of Sports Medicine for Health Promotion Tokyo Medical University Tokyo JapanDepartment of Sports Medicine for Health Promotion Tokyo Medical University Tokyo JapanDepartment of Sports Medicine for Health Promotion Tokyo Medical University Tokyo JapanDepartment of Sports Medicine for Health Promotion Tokyo Medical University Tokyo JapanAbstract Background and Objective The importance of brown adipose tissue (BAT) is well recognized in healthy infants and children. However, information regarding age‐related changes in BAT vascular density (BAT‐d) and the impact of BAT‐d on body adiposity are lacking. This study aimed to evaluate the normal values of BAT‐d, factors influencing BAT‐d, and the impact of BAT‐d on body adiposity in healthy infants and children. Methods This study included 240 participants (127 girls and 113 boys) aged 1 month to 5 years. The tissue total hemoglobin concentration in the supraclavicular region adjusted according to the subcutaneous adipose tissue thickness (SAT) ([total‐Hb‐Adj]sup) as BAT‐d. SAT in the deltoid and interscapular regions (SATdel+int), the Kaup index (body weight [g]/height or length [cm]/height or length [cm] × 10) as body adiposity, and fertilization season were also measured. Results The [total‐Hb‐Adj]sup of boys was higher than that of girls (r = 0.277, p = 0.009). Younger children had a significantly higher Kaup index (r = 0.495, p < 0.001) and SATdel+int (r = 0.614, p < 0.001) than older children. Children who had higher [total‐Hb‐Adj]sup had a significantly lower Kaup index (r = 0.495, p = 0.037) and SATdel+int (r = 0.614, p < 0.001). Conclusion The [total‐Hb‐Adj]sup, as a parameter of BAT‐d, is negatively correlated with body adiposity in children aged 1 month to 5 years, and BAT might affect human obesity to a much greater extent than expected. To prevent or treat obesity in early childhood, the level of BAT‐d should be considered when using a dietary intervention.https://doi.org/10.1002/osp4.559adipositybrown adipose tissueobesitypediatrics |
| spellingShingle | Miyuki Kuroiwa Sayuri Hamaoka‐Fuse Shiho Amagasa Ryotaro Kime Tasuki Endo Riki Tanaka Yuko Kurosawa Takafumi Hamaoka Impact of brown adipose tissue vascular density on body adiposity in healthy Japanese infants and children Obesity Science & Practice adiposity brown adipose tissue obesity pediatrics |
| title | Impact of brown adipose tissue vascular density on body adiposity in healthy Japanese infants and children |
| title_full | Impact of brown adipose tissue vascular density on body adiposity in healthy Japanese infants and children |
| title_fullStr | Impact of brown adipose tissue vascular density on body adiposity in healthy Japanese infants and children |
| title_full_unstemmed | Impact of brown adipose tissue vascular density on body adiposity in healthy Japanese infants and children |
| title_short | Impact of brown adipose tissue vascular density on body adiposity in healthy Japanese infants and children |
| title_sort | impact of brown adipose tissue vascular density on body adiposity in healthy japanese infants and children |
| topic | adiposity brown adipose tissue obesity pediatrics |
| url | https://doi.org/10.1002/osp4.559 |
| work_keys_str_mv | AT miyukikuroiwa impactofbrownadiposetissuevasculardensityonbodyadiposityinhealthyjapaneseinfantsandchildren AT sayurihamaokafuse impactofbrownadiposetissuevasculardensityonbodyadiposityinhealthyjapaneseinfantsandchildren AT shihoamagasa impactofbrownadiposetissuevasculardensityonbodyadiposityinhealthyjapaneseinfantsandchildren AT ryotarokime impactofbrownadiposetissuevasculardensityonbodyadiposityinhealthyjapaneseinfantsandchildren AT tasukiendo impactofbrownadiposetissuevasculardensityonbodyadiposityinhealthyjapaneseinfantsandchildren AT rikitanaka impactofbrownadiposetissuevasculardensityonbodyadiposityinhealthyjapaneseinfantsandchildren AT yukokurosawa impactofbrownadiposetissuevasculardensityonbodyadiposityinhealthyjapaneseinfantsandchildren AT takafumihamaoka impactofbrownadiposetissuevasculardensityonbodyadiposityinhealthyjapaneseinfantsandchildren |