Sensory Phenotype of the Oesophageal Mucosa in Gastro-Oesophageal Reflux Disease
Gastroesophageal reflux disease (GORD) affects up to 20% of Western populations, yet sensory mechanisms underlying heartburn pathogenesis remain incompletely understood. While central mechanisms of heartburn perception have been established in earlier studies, recent studies have highlighted an impo...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/3/2502 |
| _version_ | 1797624322685140992 |
|---|---|
| author | Ahsen Ustaoglu Philip Woodland |
| author_facet | Ahsen Ustaoglu Philip Woodland |
| author_sort | Ahsen Ustaoglu |
| collection | DOAJ |
| description | Gastroesophageal reflux disease (GORD) affects up to 20% of Western populations, yet sensory mechanisms underlying heartburn pathogenesis remain incompletely understood. While central mechanisms of heartburn perception have been established in earlier studies, recent studies have highlighted an important role of neurochemical, inflammatory, and cellular changes occurring in the oesophageal mucosa itself. The localization and neurochemical characterisation of sensory afferent nerve endings differ among GORD phenotypes, and could explain symptom heterogeneity among patients who are exposed to similar levels of reflux. Acid-induced stimulation of nociceptors on pain-sensing nerve endings can regulate afferent signal transmission. This review considers the role of peripheral mechanisms of sensitization in the amplification of oesophageal sensitivity in patients with GORD. |
| first_indexed | 2024-03-11T09:40:45Z |
| format | Article |
| id | doaj.art-4ca3413187624bbca4d9ba3fac6be319 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:40:45Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4ca3413187624bbca4d9ba3fac6be3192023-11-16T16:58:12ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01243250210.3390/ijms24032502Sensory Phenotype of the Oesophageal Mucosa in Gastro-Oesophageal Reflux DiseaseAhsen Ustaoglu0Philip Woodland1Wingate Institute of Neurogastroenterology, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UKWingate Institute of Neurogastroenterology, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UKGastroesophageal reflux disease (GORD) affects up to 20% of Western populations, yet sensory mechanisms underlying heartburn pathogenesis remain incompletely understood. While central mechanisms of heartburn perception have been established in earlier studies, recent studies have highlighted an important role of neurochemical, inflammatory, and cellular changes occurring in the oesophageal mucosa itself. The localization and neurochemical characterisation of sensory afferent nerve endings differ among GORD phenotypes, and could explain symptom heterogeneity among patients who are exposed to similar levels of reflux. Acid-induced stimulation of nociceptors on pain-sensing nerve endings can regulate afferent signal transmission. This review considers the role of peripheral mechanisms of sensitization in the amplification of oesophageal sensitivity in patients with GORD.https://www.mdpi.com/1422-0067/24/3/2502GORDperipheral sensitizationheartburnoesophageal mucosa |
| spellingShingle | Ahsen Ustaoglu Philip Woodland Sensory Phenotype of the Oesophageal Mucosa in Gastro-Oesophageal Reflux Disease International Journal of Molecular Sciences GORD peripheral sensitization heartburn oesophageal mucosa |
| title | Sensory Phenotype of the Oesophageal Mucosa in Gastro-Oesophageal Reflux Disease |
| title_full | Sensory Phenotype of the Oesophageal Mucosa in Gastro-Oesophageal Reflux Disease |
| title_fullStr | Sensory Phenotype of the Oesophageal Mucosa in Gastro-Oesophageal Reflux Disease |
| title_full_unstemmed | Sensory Phenotype of the Oesophageal Mucosa in Gastro-Oesophageal Reflux Disease |
| title_short | Sensory Phenotype of the Oesophageal Mucosa in Gastro-Oesophageal Reflux Disease |
| title_sort | sensory phenotype of the oesophageal mucosa in gastro oesophageal reflux disease |
| topic | GORD peripheral sensitization heartburn oesophageal mucosa |
| url | https://www.mdpi.com/1422-0067/24/3/2502 |
| work_keys_str_mv | AT ahsenustaoglu sensoryphenotypeoftheoesophagealmucosaingastrooesophagealrefluxdisease AT philipwoodland sensoryphenotypeoftheoesophagealmucosaingastrooesophagealrefluxdisease |