Epigenetic therapy reprograms M2-type tumor-associated macrophages into an M1-like phenotype by upregulating miR-7083-5p

Epigenetic therapy reprograms M2-type tumor-associated macrophages into an M1-like phenotype by upregulating miR-7083-5p

Reprogramming M2-type, pro-tumoral tumor-associated macrophages (TAMs) into M1-type, anti-tumoral macrophages is a key strategy in cancer therapy. In this study, we exploited epigenetic therapy using the DNA methylation inhibitor 5-aza-2’-deoxycytidine (5-aza-dC) and the histone deacetylation inhibi...

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Bibliographic Details
Main Authors: Sri Murugan Poongkavithai Vadevoo, Gowri Rangaswamy Gunassekaran, Jae Do Yoo, Tae-Hwan Kwon, Keun Hur, Sehyun Chae, Byungheon Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
5-aza-2’-deoxycytidine
epigenetic therapy
macrophage reprogramming
miR-7083-5p
trichostatin A
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.976196/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.976196/full

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