An Imidazo[1,5-a]pyridine Benzopyrylium-Based NIR Fluorescent Probe with Ultra-Large Stokes Shifts for Monitoring SO<sub>2</sub>
A mitochondria-targeted NIR probe based on the FRET mechanism was developed. It shows ultra-large Stokes shifts (460 nm) and emission shifts (285 nm). Furthermore, we also realized the imaging of SO<sub>2</sub> in living SKOV-3 cells, zebrafish and living mice which may be useful for und...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/2/515 |
| _version_ | 1827622987511103488 |
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| author | Renle Cui Caihong Liu Ping Zhang Kun Qin Yanqing Ge |
| author_facet | Renle Cui Caihong Liu Ping Zhang Kun Qin Yanqing Ge |
| author_sort | Renle Cui |
| collection | DOAJ |
| description | A mitochondria-targeted NIR probe based on the FRET mechanism was developed. It shows ultra-large Stokes shifts (460 nm) and emission shifts (285 nm). Furthermore, we also realized the imaging of SO<sub>2</sub> in living SKOV-3 cells, zebrafish and living mice which may be useful for understanding the biological roles of SO<sub>2</sub> in mitochondria and in vivo. |
| first_indexed | 2024-03-09T11:36:53Z |
| format | Article |
| id | doaj.art-4ca8f14a97e54cad94379aad9f55bb20 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T11:36:53Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4ca8f14a97e54cad94379aad9f55bb202023-11-30T23:40:56ZengMDPI AGMolecules1420-30492023-01-0128251510.3390/molecules28020515An Imidazo[1,5-a]pyridine Benzopyrylium-Based NIR Fluorescent Probe with Ultra-Large Stokes Shifts for Monitoring SO<sub>2</sub>Renle Cui0Caihong Liu1Ping Zhang2Kun Qin3Yanqing Ge4Department of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 619, Changcheng Road, Taian 271016, ChinaDepartment of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 619, Changcheng Road, Taian 271016, ChinaDepartment of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 619, Changcheng Road, Taian 271016, ChinaDepartment of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 619, Changcheng Road, Taian 271016, ChinaDepartment of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, No. 619, Changcheng Road, Taian 271016, ChinaA mitochondria-targeted NIR probe based on the FRET mechanism was developed. It shows ultra-large Stokes shifts (460 nm) and emission shifts (285 nm). Furthermore, we also realized the imaging of SO<sub>2</sub> in living SKOV-3 cells, zebrafish and living mice which may be useful for understanding the biological roles of SO<sub>2</sub> in mitochondria and in vivo.https://www.mdpi.com/1420-3049/28/2/515ultra-large Stokes shiftsimidazo[1,2-a]pyridinebioimagingFRETmitochondria |
| spellingShingle | Renle Cui Caihong Liu Ping Zhang Kun Qin Yanqing Ge An Imidazo[1,5-a]pyridine Benzopyrylium-Based NIR Fluorescent Probe with Ultra-Large Stokes Shifts for Monitoring SO<sub>2</sub> Molecules ultra-large Stokes shifts imidazo[1,2-a]pyridine bioimaging FRET mitochondria |
| title | An Imidazo[1,5-a]pyridine Benzopyrylium-Based NIR Fluorescent Probe with Ultra-Large Stokes Shifts for Monitoring SO<sub>2</sub> |
| title_full | An Imidazo[1,5-a]pyridine Benzopyrylium-Based NIR Fluorescent Probe with Ultra-Large Stokes Shifts for Monitoring SO<sub>2</sub> |
| title_fullStr | An Imidazo[1,5-a]pyridine Benzopyrylium-Based NIR Fluorescent Probe with Ultra-Large Stokes Shifts for Monitoring SO<sub>2</sub> |
| title_full_unstemmed | An Imidazo[1,5-a]pyridine Benzopyrylium-Based NIR Fluorescent Probe with Ultra-Large Stokes Shifts for Monitoring SO<sub>2</sub> |
| title_short | An Imidazo[1,5-a]pyridine Benzopyrylium-Based NIR Fluorescent Probe with Ultra-Large Stokes Shifts for Monitoring SO<sub>2</sub> |
| title_sort | imidazo 1 5 a pyridine benzopyrylium based nir fluorescent probe with ultra large stokes shifts for monitoring so sub 2 sub |
| topic | ultra-large Stokes shifts imidazo[1,2-a]pyridine bioimaging FRET mitochondria |
| url | https://www.mdpi.com/1420-3049/28/2/515 |
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