Syngeneic model of carcinogen-induced tumor mimics basal/squamous, stromal-rich, and neuroendocrine molecular and immunological features of muscle-invasive bladder cancer

Syngeneic model of carcinogen-induced tumor mimics basal/squamous, stromal-rich, and neuroendocrine molecular and immunological features of muscle-invasive bladder cancer

IntroductionBladder cancer is a heterogenous disease and the emerging knowledge on molecular classification of bladder tumors may impact treatment decisions based on molecular subtype. Pre-clinical models representing each subtype are needed to test novel therapies. Carcinogen-induced bladder cancer...

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Bibliographic Details
Main Authors:	Shruti D. Shah, Bryan M. Gillard, Michelle M. Wrobel, Ellen Karasik, Michael T. Moser, Michalis Mastri, Mark D. Long, Norbert Sule, Craig M. Brackett, Wendy J. Huss, Barbara A. Foster
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-02-01
Series:	Frontiers in Oncology
Subjects:	BBN carcinogen-induced bladder cancer molecular subtype CIBERSORT male and female sex disparity immune-intact mouse model immune tumor microenvironment
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2023.1120329/full

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