Asiatic acid prevents lipid peroxidation and improves antioxidant status in rats with streptozotocin-induced diabetes
Oxidative stress is a common pathogenesis of diabetes mellitus and asiatic acid (AA) plays an important role in ameliorating those difficulties. The present study was designed the protective effects of AA on altered lipid peroxidation products, enzymic and nonenzymic antioxidants in streptozotocin (...
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| Format: | Article |
| Language: | English |
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Elsevier
2013-07-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464613000728 |
| _version_ | 1818690504060043264 |
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| author | Vinayagam Ramachandran Ramalingam Saravanan |
| author_facet | Vinayagam Ramachandran Ramalingam Saravanan |
| author_sort | Vinayagam Ramachandran |
| collection | DOAJ |
| description | Oxidative stress is a common pathogenesis of diabetes mellitus and asiatic acid (AA) plays an important role in ameliorating those difficulties. The present study was designed the protective effects of AA on altered lipid peroxidation products, enzymic and nonenzymic antioxidants in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced in experimental rats by single dose STZ (40 mg/kg b.w.) injection. Diabetic rats showed significantly increased levels of plasma glucose, thiobarbituric acid reactive substances, lipid hydroperoxides, aspartate aminotransferase, alanine aminotransferase, bilirubin, creatine kinase, urea, uric acid, creatinine and decreased levels of plasma insulin. The activities of enzymatic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase and the levels of non-enzymatic antioxidants such as vitamin C, vitamin E and reduced glutathione were decreased in diabetic rats. Oral treatment with AA (20 mg/kg b.w.) showed near normalized levels of plasma glucose, insulin, lipid peroxidation products, enzymatic and nonenzymatic markers in diabetic rats. The results demonstrate that AA possesses potent antioxidant effect comparable with glibenclamide in improving antihyperglycemia and attenuating antioxidant status in diabetic rats. |
| first_indexed | 2024-12-17T12:27:03Z |
| format | Article |
| id | doaj.art-4ca9638ccf2d4fac878941d5d01ae48f |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T12:27:03Z |
| publishDate | 2013-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-4ca9638ccf2d4fac878941d5d01ae48f2022-12-21T21:48:42ZengElsevierJournal of Functional Foods1756-46462013-07-015310771087Asiatic acid prevents lipid peroxidation and improves antioxidant status in rats with streptozotocin-induced diabetesVinayagam Ramachandran0Ramalingam Saravanan1Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608 002, Tamil Nadu, IndiaCorresponding author. Tel.: +91 4144 238343; fax: +91 4144 239141.; Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608 002, Tamil Nadu, IndiaOxidative stress is a common pathogenesis of diabetes mellitus and asiatic acid (AA) plays an important role in ameliorating those difficulties. The present study was designed the protective effects of AA on altered lipid peroxidation products, enzymic and nonenzymic antioxidants in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced in experimental rats by single dose STZ (40 mg/kg b.w.) injection. Diabetic rats showed significantly increased levels of plasma glucose, thiobarbituric acid reactive substances, lipid hydroperoxides, aspartate aminotransferase, alanine aminotransferase, bilirubin, creatine kinase, urea, uric acid, creatinine and decreased levels of plasma insulin. The activities of enzymatic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase and the levels of non-enzymatic antioxidants such as vitamin C, vitamin E and reduced glutathione were decreased in diabetic rats. Oral treatment with AA (20 mg/kg b.w.) showed near normalized levels of plasma glucose, insulin, lipid peroxidation products, enzymatic and nonenzymatic markers in diabetic rats. The results demonstrate that AA possesses potent antioxidant effect comparable with glibenclamide in improving antihyperglycemia and attenuating antioxidant status in diabetic rats.http://www.sciencedirect.com/science/article/pii/S1756464613000728Asiatic acidStreptozotocinAntidiabeticAntioxidantOxidative stress |
| spellingShingle | Vinayagam Ramachandran Ramalingam Saravanan Asiatic acid prevents lipid peroxidation and improves antioxidant status in rats with streptozotocin-induced diabetes Journal of Functional Foods Asiatic acid Streptozotocin Antidiabetic Antioxidant Oxidative stress |
| title | Asiatic acid prevents lipid peroxidation and improves antioxidant status in rats with streptozotocin-induced diabetes |
| title_full | Asiatic acid prevents lipid peroxidation and improves antioxidant status in rats with streptozotocin-induced diabetes |
| title_fullStr | Asiatic acid prevents lipid peroxidation and improves antioxidant status in rats with streptozotocin-induced diabetes |
| title_full_unstemmed | Asiatic acid prevents lipid peroxidation and improves antioxidant status in rats with streptozotocin-induced diabetes |
| title_short | Asiatic acid prevents lipid peroxidation and improves antioxidant status in rats with streptozotocin-induced diabetes |
| title_sort | asiatic acid prevents lipid peroxidation and improves antioxidant status in rats with streptozotocin induced diabetes |
| topic | Asiatic acid Streptozotocin Antidiabetic Antioxidant Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S1756464613000728 |
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