Discovery and Anticancer Activity of the Plagiochilins from the Liverwort Genus <i>Plagiochila</i>
The present analysis retraces the discovery of plagiochilins A-to-W, a series of seco-aromadendrane-type sesquiterpenes isolated from diverse leafy liverworts of the genus <i>Plagiochila</i>. Between 1978, with the first isolation of the leader product plagiochilin A from <i>P. yok...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/3/758 |
| _version_ | 1797610574992900096 |
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| author | Christian Bailly |
| author_facet | Christian Bailly |
| author_sort | Christian Bailly |
| collection | DOAJ |
| description | The present analysis retraces the discovery of plagiochilins A-to-W, a series of seco-aromadendrane-type sesquiterpenes isolated from diverse leafy liverworts of the genus <i>Plagiochila</i>. Between 1978, with the first isolation of the leader product plagiochilin A from <i>P. yokogurensis</i>, and 2005, with the characterization of plagiochilin X from <i>P. asplenioides</i>, a set of 24 plagiochilins and several derivatives (plagiochilide, plagiochilal A-B) has been isolated and characterized. Analogue compounds recently described are also evoked, such as the plagiochianins and plagicosins. All these compounds have been little studied from a pharmacological viewpoint. However, plagiochilins A and C have revealed marked antiproliferative activities against cultured cancer cells. Plagiochilin A functions as an inhibitor of the termination phase of cytokinesis: the membrane abscission stage. This unique, innovative mechanism of action, coupled with its marked anticancer action, notably against prostate cancer cells, make plagiochilin A an interesting lead molecule for the development of novel anticancer agents. There are known options to increase its potency, as deduced from structure–activity relationships. The analysis shed light on this family of bryophyte species and the little-known group of bioactive terpenoid plagiochilins. Plagiochilin A and derivatives shall be further exploited for the design of novel anticancer targeting the cytokinesis pathway. |
| first_indexed | 2024-03-11T06:17:08Z |
| format | Article |
| id | doaj.art-4ca9eaafefcf4dfbaa8494e51927e55c |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T06:17:08Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-4ca9eaafefcf4dfbaa8494e51927e55c2023-11-17T12:11:58ZengMDPI AGLife2075-17292023-03-0113375810.3390/life13030758Discovery and Anticancer Activity of the Plagiochilins from the Liverwort Genus <i>Plagiochila</i>Christian Bailly0Institut de Chimie Pharmaceutique Albert Lespagnol (ICPAL), Faculté de Pharmacie, University of Lille, 3 rue du Professeur Laguesse, F-59006 Lille, FranceThe present analysis retraces the discovery of plagiochilins A-to-W, a series of seco-aromadendrane-type sesquiterpenes isolated from diverse leafy liverworts of the genus <i>Plagiochila</i>. Between 1978, with the first isolation of the leader product plagiochilin A from <i>P. yokogurensis</i>, and 2005, with the characterization of plagiochilin X from <i>P. asplenioides</i>, a set of 24 plagiochilins and several derivatives (plagiochilide, plagiochilal A-B) has been isolated and characterized. Analogue compounds recently described are also evoked, such as the plagiochianins and plagicosins. All these compounds have been little studied from a pharmacological viewpoint. However, plagiochilins A and C have revealed marked antiproliferative activities against cultured cancer cells. Plagiochilin A functions as an inhibitor of the termination phase of cytokinesis: the membrane abscission stage. This unique, innovative mechanism of action, coupled with its marked anticancer action, notably against prostate cancer cells, make plagiochilin A an interesting lead molecule for the development of novel anticancer agents. There are known options to increase its potency, as deduced from structure–activity relationships. The analysis shed light on this family of bryophyte species and the little-known group of bioactive terpenoid plagiochilins. Plagiochilin A and derivatives shall be further exploited for the design of novel anticancer targeting the cytokinesis pathway.https://www.mdpi.com/2075-1729/13/3/758anticancer agentsaromadendranebryophytescytokinesis inhibitor<i>Plagiochila</i> speciesplagiochilins |
| spellingShingle | Christian Bailly Discovery and Anticancer Activity of the Plagiochilins from the Liverwort Genus <i>Plagiochila</i> Life anticancer agents aromadendrane bryophytes cytokinesis inhibitor <i>Plagiochila</i> species plagiochilins |
| title | Discovery and Anticancer Activity of the Plagiochilins from the Liverwort Genus <i>Plagiochila</i> |
| title_full | Discovery and Anticancer Activity of the Plagiochilins from the Liverwort Genus <i>Plagiochila</i> |
| title_fullStr | Discovery and Anticancer Activity of the Plagiochilins from the Liverwort Genus <i>Plagiochila</i> |
| title_full_unstemmed | Discovery and Anticancer Activity of the Plagiochilins from the Liverwort Genus <i>Plagiochila</i> |
| title_short | Discovery and Anticancer Activity of the Plagiochilins from the Liverwort Genus <i>Plagiochila</i> |
| title_sort | discovery and anticancer activity of the plagiochilins from the liverwort genus i plagiochila i |
| topic | anticancer agents aromadendrane bryophytes cytokinesis inhibitor <i>Plagiochila</i> species plagiochilins |
| url | https://www.mdpi.com/2075-1729/13/3/758 |
| work_keys_str_mv | AT christianbailly discoveryandanticanceractivityoftheplagiochilinsfromtheliverwortgenusiplagiochilai |