Effects of Hypoxemia by Acute High-Altitude Exposure on Human Intestinal Flora and Metabolism
This study examined the effects of hypoxemia caused by acute high-altitude hypoxia (AHAH) exposure on the human intestinal flora and its metabolites. The changes in the intestinal flora, metabolism, and erythropoietin content in the AHAH population under altitude hypoxia conditions were comprehensiv...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-09-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/11/9/2284 |
| _version_ | 1797578730914185216 |
|---|---|
| author | Ping Qi Jin Lv Liu-Hui Bai Xiang-Dong Yan Lei Zhang |
| author_facet | Ping Qi Jin Lv Liu-Hui Bai Xiang-Dong Yan Lei Zhang |
| author_sort | Ping Qi |
| collection | DOAJ |
| description | This study examined the effects of hypoxemia caused by acute high-altitude hypoxia (AHAH) exposure on the human intestinal flora and its metabolites. The changes in the intestinal flora, metabolism, and erythropoietin content in the AHAH population under altitude hypoxia conditions were comprehensively analyzed using 16S rRNA sequencing, metabonomics, and erythropoietin content. The results showed that compared with those in the control group (C group), the flora and metabolites in the hypoxemia group (D group) were altered. We found alterations in the flora according to the metabolic marker tyrosine through random forest and ROC analyses. Fecal and serum metabonomics analyses revealed that microbial metabolites could be absorbed into the blood and participate in human metabolism. Finally, a significant correlation between tyrosine and erythropoietin (EPO) content was found, which shows that human intestinal flora and its metabolites can help to confront altitude stress by regulating EPO levels. Our findings provide new insights into the adaptive mechanism and prevention of AHAH. |
| first_indexed | 2024-03-10T22:25:58Z |
| format | Article |
| id | doaj.art-4caa2b11d7464fb4a2cff639cd279fdd |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T22:25:58Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-4caa2b11d7464fb4a2cff639cd279fdd2023-11-19T12:03:13ZengMDPI AGMicroorganisms2076-26072023-09-01119228410.3390/microorganisms11092284Effects of Hypoxemia by Acute High-Altitude Exposure on Human Intestinal Flora and MetabolismPing Qi0Jin Lv1Liu-Hui Bai2Xiang-Dong Yan3Lei Zhang4The First Clinical Medical College, Lanzhou University, Lanzhou 730000, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou 730000, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou 730000, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou 730000, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou 730000, ChinaThis study examined the effects of hypoxemia caused by acute high-altitude hypoxia (AHAH) exposure on the human intestinal flora and its metabolites. The changes in the intestinal flora, metabolism, and erythropoietin content in the AHAH population under altitude hypoxia conditions were comprehensively analyzed using 16S rRNA sequencing, metabonomics, and erythropoietin content. The results showed that compared with those in the control group (C group), the flora and metabolites in the hypoxemia group (D group) were altered. We found alterations in the flora according to the metabolic marker tyrosine through random forest and ROC analyses. Fecal and serum metabonomics analyses revealed that microbial metabolites could be absorbed into the blood and participate in human metabolism. Finally, a significant correlation between tyrosine and erythropoietin (EPO) content was found, which shows that human intestinal flora and its metabolites can help to confront altitude stress by regulating EPO levels. Our findings provide new insights into the adaptive mechanism and prevention of AHAH.https://www.mdpi.com/2076-2607/11/9/2284acute high-altitude hypoxiahypoxemiagut microbiomemetabolismerythropoietin |
| spellingShingle | Ping Qi Jin Lv Liu-Hui Bai Xiang-Dong Yan Lei Zhang Effects of Hypoxemia by Acute High-Altitude Exposure on Human Intestinal Flora and Metabolism Microorganisms acute high-altitude hypoxia hypoxemia gut microbiome metabolism erythropoietin |
| title | Effects of Hypoxemia by Acute High-Altitude Exposure on Human Intestinal Flora and Metabolism |
| title_full | Effects of Hypoxemia by Acute High-Altitude Exposure on Human Intestinal Flora and Metabolism |
| title_fullStr | Effects of Hypoxemia by Acute High-Altitude Exposure on Human Intestinal Flora and Metabolism |
| title_full_unstemmed | Effects of Hypoxemia by Acute High-Altitude Exposure on Human Intestinal Flora and Metabolism |
| title_short | Effects of Hypoxemia by Acute High-Altitude Exposure on Human Intestinal Flora and Metabolism |
| title_sort | effects of hypoxemia by acute high altitude exposure on human intestinal flora and metabolism |
| topic | acute high-altitude hypoxia hypoxemia gut microbiome metabolism erythropoietin |
| url | https://www.mdpi.com/2076-2607/11/9/2284 |
| work_keys_str_mv | AT pingqi effectsofhypoxemiabyacutehighaltitudeexposureonhumanintestinalfloraandmetabolism AT jinlv effectsofhypoxemiabyacutehighaltitudeexposureonhumanintestinalfloraandmetabolism AT liuhuibai effectsofhypoxemiabyacutehighaltitudeexposureonhumanintestinalfloraandmetabolism AT xiangdongyan effectsofhypoxemiabyacutehighaltitudeexposureonhumanintestinalfloraandmetabolism AT leizhang effectsofhypoxemiabyacutehighaltitudeexposureonhumanintestinalfloraandmetabolism |