Liver transplantation versus resection for patients with combined hepatocellular cholangiocarcinoma: A retrospective cohort study
Background: Combined hepatocellular cholangiocarcinoma (CHC) is a rare primary liver cancer, and whether liver transplantation should be implemented among CHC patients is still controversial. We intend to conduct a retrospective cohort study based on the Surveillance, Epidemiology, and End Results (...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-10-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023081537 |
| _version_ | 1797646443189633024 |
|---|---|
| author | Shizheng Mi Ziqi Hou Guoteng Qiu Zhaoxing Jin Qingyun Xie Jiwei Huang |
| author_facet | Shizheng Mi Ziqi Hou Guoteng Qiu Zhaoxing Jin Qingyun Xie Jiwei Huang |
| author_sort | Shizheng Mi |
| collection | DOAJ |
| description | Background: Combined hepatocellular cholangiocarcinoma (CHC) is a rare primary liver cancer, and whether liver transplantation should be implemented among CHC patients is still controversial. We intend to conduct a retrospective cohort study based on the Surveillance, Epidemiology, and End Results (SEER) database to investigate the prognosis of liver transplantation vs. liver resection among CHC patients. Methods: Patients diagnosed with CHC (ICD-O-3:8180/3) and treated with transplantation or hepatectomy were extracted from the SEER database (2000–2018). We utilized Propensity Score Matching to control confounding bias. Kaplan-Meier curve was used for survival analysis, and Cox regression was used to find independent factors associated with prognosis. Results: We identified 123 (transplantation: 49; resection: 74) patients with CHC who were treated between 2004 and 2015. In the entire cohort, survival analysis demonstrated transplantation group was associated with better overall survival and cancer-specific survival (log-rank p = 0.004 and p = 0.003, respectively). In addition, liver transplantation still conferred better overall and cancer-specific survival than liver resection after Propensity Score Matching (log-rank p = 0.024 and p = 0.048, respectively). However, this advantage didn't appear in the subgroup, regardless of whether the tumor size was greater than 3 cm or not. (≤3 cm: OS log-rank p = 0.230, CSS log-rank p = 0.370; >3 cm: OS log-rank p = 0.110, CSS log-rank p = 0.084). Multivariate analysis validated the finding that liver transplantation was a protective factor for overall survival (HR = 0.55 [0.31–0.95], p = 0.032). Conclusions: Liver transplantation may be an option in individuals with CHC and should be taken into consideration due to its advantages in terms of overall survival and cancer-specific survival. However, a sizable sample is required for future studies to determine which subset of CHC patients may benefit more from liver transplantation. |
| first_indexed | 2024-03-11T15:01:40Z |
| format | Article |
| id | doaj.art-4cabd909f1474458828bbef4c51bffab |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-11T15:01:40Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-4cabd909f1474458828bbef4c51bffab2023-10-30T06:07:56ZengElsevierHeliyon2405-84402023-10-01910e20945Liver transplantation versus resection for patients with combined hepatocellular cholangiocarcinoma: A retrospective cohort studyShizheng Mi0Ziqi Hou1Guoteng Qiu2Zhaoxing Jin3Qingyun Xie4Jiwei Huang5Department of Liver Surgery and Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Liver Surgery and Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Liver Surgery and Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Liver Surgery and Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Liver Surgery and Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu, ChinaCorresponding author. Department of Liver Surgery and Liver Transplantation Center, West China Hospital, Sichuan University, No. 37 GuoXueXiang Road, Wuhou District, Chengdu, 610041, China.; Department of Liver Surgery and Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu, ChinaBackground: Combined hepatocellular cholangiocarcinoma (CHC) is a rare primary liver cancer, and whether liver transplantation should be implemented among CHC patients is still controversial. We intend to conduct a retrospective cohort study based on the Surveillance, Epidemiology, and End Results (SEER) database to investigate the prognosis of liver transplantation vs. liver resection among CHC patients. Methods: Patients diagnosed with CHC (ICD-O-3:8180/3) and treated with transplantation or hepatectomy were extracted from the SEER database (2000–2018). We utilized Propensity Score Matching to control confounding bias. Kaplan-Meier curve was used for survival analysis, and Cox regression was used to find independent factors associated with prognosis. Results: We identified 123 (transplantation: 49; resection: 74) patients with CHC who were treated between 2004 and 2015. In the entire cohort, survival analysis demonstrated transplantation group was associated with better overall survival and cancer-specific survival (log-rank p = 0.004 and p = 0.003, respectively). In addition, liver transplantation still conferred better overall and cancer-specific survival than liver resection after Propensity Score Matching (log-rank p = 0.024 and p = 0.048, respectively). However, this advantage didn't appear in the subgroup, regardless of whether the tumor size was greater than 3 cm or not. (≤3 cm: OS log-rank p = 0.230, CSS log-rank p = 0.370; >3 cm: OS log-rank p = 0.110, CSS log-rank p = 0.084). Multivariate analysis validated the finding that liver transplantation was a protective factor for overall survival (HR = 0.55 [0.31–0.95], p = 0.032). Conclusions: Liver transplantation may be an option in individuals with CHC and should be taken into consideration due to its advantages in terms of overall survival and cancer-specific survival. However, a sizable sample is required for future studies to determine which subset of CHC patients may benefit more from liver transplantation.http://www.sciencedirect.com/science/article/pii/S2405844023081537Liver transplantationHepatectomyCombined hepatocellular cholangiocarcinomaOverall survivalCancer-specific survival |
| spellingShingle | Shizheng Mi Ziqi Hou Guoteng Qiu Zhaoxing Jin Qingyun Xie Jiwei Huang Liver transplantation versus resection for patients with combined hepatocellular cholangiocarcinoma: A retrospective cohort study Heliyon Liver transplantation Hepatectomy Combined hepatocellular cholangiocarcinoma Overall survival Cancer-specific survival |
| title | Liver transplantation versus resection for patients with combined hepatocellular cholangiocarcinoma: A retrospective cohort study |
| title_full | Liver transplantation versus resection for patients with combined hepatocellular cholangiocarcinoma: A retrospective cohort study |
| title_fullStr | Liver transplantation versus resection for patients with combined hepatocellular cholangiocarcinoma: A retrospective cohort study |
| title_full_unstemmed | Liver transplantation versus resection for patients with combined hepatocellular cholangiocarcinoma: A retrospective cohort study |
| title_short | Liver transplantation versus resection for patients with combined hepatocellular cholangiocarcinoma: A retrospective cohort study |
| title_sort | liver transplantation versus resection for patients with combined hepatocellular cholangiocarcinoma a retrospective cohort study |
| topic | Liver transplantation Hepatectomy Combined hepatocellular cholangiocarcinoma Overall survival Cancer-specific survival |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023081537 |
| work_keys_str_mv | AT shizhengmi livertransplantationversusresectionforpatientswithcombinedhepatocellularcholangiocarcinomaaretrospectivecohortstudy AT ziqihou livertransplantationversusresectionforpatientswithcombinedhepatocellularcholangiocarcinomaaretrospectivecohortstudy AT guotengqiu livertransplantationversusresectionforpatientswithcombinedhepatocellularcholangiocarcinomaaretrospectivecohortstudy AT zhaoxingjin livertransplantationversusresectionforpatientswithcombinedhepatocellularcholangiocarcinomaaretrospectivecohortstudy AT qingyunxie livertransplantationversusresectionforpatientswithcombinedhepatocellularcholangiocarcinomaaretrospectivecohortstudy AT jiweihuang livertransplantationversusresectionforpatientswithcombinedhepatocellularcholangiocarcinomaaretrospectivecohortstudy |