Klotho Modulates Pro-Fibrotic Activities in Human Atrial Fibroblasts through Inhibition of Phospholipase C Signaling and Suppression of Store-Operated Calcium Entry

Klotho Modulates Pro-Fibrotic Activities in Human Atrial Fibroblasts through Inhibition of Phospholipase C Signaling and Suppression of Store-Operated Calcium Entry

Background: Atrial fibroblasts activation causes atrial fibrosis, which is one major pathophysiological contributor to atrial fibrillation (AF) genesis. Klotho is a pleiotropic protein with remarkable cardiovascular effects, including anti-inflammatory, anti-oxidative, and anti-apoptotic effects. Th...

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Bibliographic Details
Main Authors: Yuan Hung, Cheng-Chih Chung, Yao-Chang Chen, Yu-Hsun Kao, Wei-Shiang Lin, Shih-Ann Chen, Yi-Jen Chen
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biomedicines
Subjects:
Klotho
atrial fibrillation
fibroblast
transient receptor potential channels
Online Access:https://www.mdpi.com/2227-9059/10/7/1574

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https://www.mdpi.com/2227-9059/10/7/1574

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