Isolated blast crisis relapse in the central nervous system of a patient treating for a chronic myelogenous leukemia
Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with the Philadelphia chromosome t (9;22) and the BCR-ABL fusion gene. The condition is relatively rare, accounting for 2.0% to 3.0% of childhood leukemia cases. CML has historically been a triphasic disease. Most patients ar...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Pan African Medical Journal
2020-06-01
|
| Series: | The Pan African Medical Journal |
| Subjects: | |
| Online Access: |
https://www.panafrican-med-journal.com/content/article/36/142/pdf/142.pdf
|
| _version_ | 1818910173878550528 |
|---|---|
| author | Houda Boudiaf Khedaoudj Ezziane Nassiba Ould Rouis Meriem Himrane Saliha Hakem Hanifa Benchabane Houria Boukhelal Radja Arous Lynda Chikhi |
| author_facet | Houda Boudiaf Khedaoudj Ezziane Nassiba Ould Rouis Meriem Himrane Saliha Hakem Hanifa Benchabane Houria Boukhelal Radja Arous Lynda Chikhi |
| author_sort | Houda Boudiaf |
| collection | DOAJ |
| description | Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with the Philadelphia chromosome t (9;22) and the BCR-ABL fusion gene. The condition is relatively rare, accounting for 2.0% to 3.0% of childhood leukemia cases. CML has historically been a triphasic disease. Most patients are diagnosed in chronic phase. Without treatment, it inevitably progresses into a more aggressive accelerated phase and blast crisis. Some proportion of CML cases of blastic transformation develop an extramedullary disease that involves rarely central nervous system. This report describe an extremely rare case of 13-year-old girl with CML and extramedullary blast crisis in the central nervous system. Treatment options and monitoring of disease response are discussed. |
| first_indexed | 2024-12-19T22:38:36Z |
| format | Article |
| id | doaj.art-4cad8cc4fa3a4120987dc033cb53dcb8 |
| institution | Directory Open Access Journal |
| issn | 1937-8688 1937-8688 |
| language | English |
| last_indexed | 2024-12-19T22:38:36Z |
| publishDate | 2020-06-01 |
| publisher | The Pan African Medical Journal |
| record_format | Article |
| series | The Pan African Medical Journal |
| spelling | doaj.art-4cad8cc4fa3a4120987dc033cb53dcb82022-12-21T20:03:08ZengThe Pan African Medical JournalThe Pan African Medical Journal1937-86881937-86882020-06-013614210.11604/pamj.2020.36.142.2415524155Isolated blast crisis relapse in the central nervous system of a patient treating for a chronic myelogenous leukemiaHouda Boudiaf0Khedaoudj Ezziane1Nassiba Ould Rouis2Meriem Himrane3Saliha Hakem4Hanifa Benchabane5Houria Boukhelal6Radja Arous7Lynda Chikhi8 Department of Pediatric Oncology, University Hospital of Mustapha Pacha, Algiers, Algeria Department of Pediatric Oncology, University Hospital of Mustapha Pacha, Algiers, Algeria Department of Pediatric Oncology, University Hospital of Mustapha Pacha, Algiers, Algeria Department of Pediatric Oncology, University Hospital of Mustapha Pacha, Algiers, Algeria Department of Pediatric Oncology, University Hospital of Mustapha Pacha, Algiers, Algeria Department of Pediatric Oncology, University Hospital of Mustapha Pacha, Algiers, Algeria Department of Pediatric Oncology, University Hospital of Mustapha Pacha, Algiers, Algeria Department of Pediatric Oncology, University Hospital of Mustapha Pacha, Algiers, Algeria Department of Blood Transfusion and Hemobiology, University Hospital of Mustapha Pacha, Algiers, Algeria Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with the Philadelphia chromosome t (9;22) and the BCR-ABL fusion gene. The condition is relatively rare, accounting for 2.0% to 3.0% of childhood leukemia cases. CML has historically been a triphasic disease. Most patients are diagnosed in chronic phase. Without treatment, it inevitably progresses into a more aggressive accelerated phase and blast crisis. Some proportion of CML cases of blastic transformation develop an extramedullary disease that involves rarely central nervous system. This report describe an extremely rare case of 13-year-old girl with CML and extramedullary blast crisis in the central nervous system. Treatment options and monitoring of disease response are discussed. https://www.panafrican-med-journal.com/content/article/36/142/pdf/142.pdf chronic myeloid leukemiacentral nervous systemblast crisisimatinib |
| spellingShingle | Houda Boudiaf Khedaoudj Ezziane Nassiba Ould Rouis Meriem Himrane Saliha Hakem Hanifa Benchabane Houria Boukhelal Radja Arous Lynda Chikhi Isolated blast crisis relapse in the central nervous system of a patient treating for a chronic myelogenous leukemia The Pan African Medical Journal chronic myeloid leukemia central nervous system blast crisis imatinib |
| title | Isolated blast crisis relapse in the central nervous system of a patient treating for a chronic myelogenous leukemia |
| title_full | Isolated blast crisis relapse in the central nervous system of a patient treating for a chronic myelogenous leukemia |
| title_fullStr | Isolated blast crisis relapse in the central nervous system of a patient treating for a chronic myelogenous leukemia |
| title_full_unstemmed | Isolated blast crisis relapse in the central nervous system of a patient treating for a chronic myelogenous leukemia |
| title_short | Isolated blast crisis relapse in the central nervous system of a patient treating for a chronic myelogenous leukemia |
| title_sort | isolated blast crisis relapse in the central nervous system of a patient treating for a chronic myelogenous leukemia |
| topic | chronic myeloid leukemia central nervous system blast crisis imatinib |
| url |
https://www.panafrican-med-journal.com/content/article/36/142/pdf/142.pdf
|
| work_keys_str_mv | AT houdaboudiaf isolatedblastcrisisrelapseinthecentralnervoussystemofapatienttreatingforachronicmyelogenousleukemia AT khedaoudjezziane isolatedblastcrisisrelapseinthecentralnervoussystemofapatienttreatingforachronicmyelogenousleukemia AT nassibaouldrouis isolatedblastcrisisrelapseinthecentralnervoussystemofapatienttreatingforachronicmyelogenousleukemia AT meriemhimrane isolatedblastcrisisrelapseinthecentralnervoussystemofapatienttreatingforachronicmyelogenousleukemia AT salihahakem isolatedblastcrisisrelapseinthecentralnervoussystemofapatienttreatingforachronicmyelogenousleukemia AT hanifabenchabane isolatedblastcrisisrelapseinthecentralnervoussystemofapatienttreatingforachronicmyelogenousleukemia AT houriaboukhelal isolatedblastcrisisrelapseinthecentralnervoussystemofapatienttreatingforachronicmyelogenousleukemia AT radjaarous isolatedblastcrisisrelapseinthecentralnervoussystemofapatienttreatingforachronicmyelogenousleukemia AT lyndachikhi isolatedblastcrisisrelapseinthecentralnervoussystemofapatienttreatingforachronicmyelogenousleukemia |