Frailty index in the Colonias of the Rio Grande Valley: health related quality of life and resilience
BackgroundFrailty is characterized by an accumulation of deficits that lead to vulnerability to adverse health outcomes. The Frailty Index (FI) quantifies frailty by measuring deficits that increase susceptibility to stressors. This study focused on a population of Mexican Americans living in vulner...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1240494/full |
| _version_ | 1827632324529881088 |
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| author | Eron G. Manusov Eron G. Manusov Vincent P. Diego Vincent P. Diego Sarah Williams-Blangero Sarah Williams-Blangero |
| author_facet | Eron G. Manusov Eron G. Manusov Vincent P. Diego Vincent P. Diego Sarah Williams-Blangero Sarah Williams-Blangero |
| author_sort | Eron G. Manusov |
| collection | DOAJ |
| description | BackgroundFrailty is characterized by an accumulation of deficits that lead to vulnerability to adverse health outcomes. The Frailty Index (FI) quantifies frailty by measuring deficits that increase susceptibility to stressors. This study focused on a population of Mexican Americans living in vulnerable communities in the Rio Grande Valley of south Texas. We used a Frailty Index developed based on common health-related data--the Patient Health Questionnaire (PHQ-9) and a Health-related Quality of Life survey (Duke Health Profile). Quality of life, resilience, and frailty are interrelated and influenced by chronic illness, mental illness, poverty, cognitive impairment, and community support.MethodsWe used Logistic regression analysis, factor component analysis, receiver operating characteristic curves, and odds ratios to identify potential associations between clinical variables and candidate predictor variables and seven physiological health variables, and two survey instruments. We analyzed data obtained from participants (894) that live in two Colonias located on the Texas-Mexico border. We calculated the FI with seven physiological variables, PHQ-9 score, and the 11 domain-specific Duke Profile scores, for a total of 19 health deficits. We then dichotomized FI (>0.25) and determined ROC curves through model selection to determine best predictors of frailty.ResultsFemales (n = 622) had a higher starting frailty, and males (n = 272) had a significantly greater change rate with age. Women score higher in anxiety, depression, anxiety/depression, and pain. The frailty index and quality of life markers are strongly inversely related; poorer quality of life leads to greater frailty independent physiological health variables, the PHQ 9, sex, and age.ConclusionThe study highlights the importance of addressing modifiable mental health and social stressors to reduce frailty. Furthermore, it suggests that factors supporting resilience and well-being, such as physical and mental health, social support, and perceived health, play a crucial role in frailty development. The findings have implications for interventions targeting vulnerable populations and emphasize the need for further research on the relationship between health-related quality of life and frailty. |
| first_indexed | 2024-03-09T14:34:31Z |
| format | Article |
| id | doaj.art-4cadf09505414148a55dcfd7401563db |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-09T14:34:31Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-4cadf09505414148a55dcfd7401563db2023-11-27T13:45:30ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-11-011010.3389/fmed.2023.12404941240494Frailty index in the Colonias of the Rio Grande Valley: health related quality of life and resilienceEron G. Manusov0Eron G. Manusov1Vincent P. Diego2Vincent P. Diego3Sarah Williams-Blangero4Sarah Williams-Blangero5Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX, United StatesSouth Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX, United StatesDepartment of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX, United StatesSouth Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX, United StatesDepartment of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX, United StatesSouth Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX, United StatesBackgroundFrailty is characterized by an accumulation of deficits that lead to vulnerability to adverse health outcomes. The Frailty Index (FI) quantifies frailty by measuring deficits that increase susceptibility to stressors. This study focused on a population of Mexican Americans living in vulnerable communities in the Rio Grande Valley of south Texas. We used a Frailty Index developed based on common health-related data--the Patient Health Questionnaire (PHQ-9) and a Health-related Quality of Life survey (Duke Health Profile). Quality of life, resilience, and frailty are interrelated and influenced by chronic illness, mental illness, poverty, cognitive impairment, and community support.MethodsWe used Logistic regression analysis, factor component analysis, receiver operating characteristic curves, and odds ratios to identify potential associations between clinical variables and candidate predictor variables and seven physiological health variables, and two survey instruments. We analyzed data obtained from participants (894) that live in two Colonias located on the Texas-Mexico border. We calculated the FI with seven physiological variables, PHQ-9 score, and the 11 domain-specific Duke Profile scores, for a total of 19 health deficits. We then dichotomized FI (>0.25) and determined ROC curves through model selection to determine best predictors of frailty.ResultsFemales (n = 622) had a higher starting frailty, and males (n = 272) had a significantly greater change rate with age. Women score higher in anxiety, depression, anxiety/depression, and pain. The frailty index and quality of life markers are strongly inversely related; poorer quality of life leads to greater frailty independent physiological health variables, the PHQ 9, sex, and age.ConclusionThe study highlights the importance of addressing modifiable mental health and social stressors to reduce frailty. Furthermore, it suggests that factors supporting resilience and well-being, such as physical and mental health, social support, and perceived health, play a crucial role in frailty development. The findings have implications for interventions targeting vulnerable populations and emphasize the need for further research on the relationship between health-related quality of life and frailty.https://www.frontiersin.org/articles/10.3389/fmed.2023.1240494/fullfrailtyMexican Americanhealth-related quality of liferesilienceSouth TexasFrailty Index |
| spellingShingle | Eron G. Manusov Eron G. Manusov Vincent P. Diego Vincent P. Diego Sarah Williams-Blangero Sarah Williams-Blangero Frailty index in the Colonias of the Rio Grande Valley: health related quality of life and resilience Frontiers in Medicine frailty Mexican American health-related quality of life resilience South Texas Frailty Index |
| title | Frailty index in the Colonias of the Rio Grande Valley: health related quality of life and resilience |
| title_full | Frailty index in the Colonias of the Rio Grande Valley: health related quality of life and resilience |
| title_fullStr | Frailty index in the Colonias of the Rio Grande Valley: health related quality of life and resilience |
| title_full_unstemmed | Frailty index in the Colonias of the Rio Grande Valley: health related quality of life and resilience |
| title_short | Frailty index in the Colonias of the Rio Grande Valley: health related quality of life and resilience |
| title_sort | frailty index in the colonias of the rio grande valley health related quality of life and resilience |
| topic | frailty Mexican American health-related quality of life resilience South Texas Frailty Index |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1240494/full |
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