Synthesis of Enantiopure (<i>S</i>)-Atenolol by Utilization of Lipase-Catalyzed Kinetic Resolution of a Key Intermediate

Synthesis of Enantiopure (<i>S</i>)-Atenolol by Utilization of Lipase-Catalyzed Kinetic Resolution of a Key Intermediate

(<i>S</i>)-Atenolol ((<i>S</i>)-2-(4-(2-Hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide) has been synthesized in >99% enantiomeric excess (<i>ee</i>) with the use of <i>Candida antarctica</i> lipase B from Syncozymes (Shanghai, China), in a kinet...

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Bibliographic Details
Main Authors: Mari Bergan Hansen, Anna Lifen Tennfjord, Fredrik Heen Blindheim, Lucas Hugo Yvan Bocquin, Elisabeth Egholm Jacobsen
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
enantiopure (<i>S</i>)-atenolol
<i>Candida antarctica</i> lipase B
base catalysis
Chiralcel OD-H column
Online Access:https://www.mdpi.com/1422-0067/25/6/3497

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