High-Throughput Screen for Inhibitors of the Type IV Pilus Assembly ATPase PilB
Many bacterial pathogens use their type IV pili (T4P) to facilitate and maintain infection of a human host. Small chemical compounds that inhibit the production or assembly of T4P have promise in the treatment and prevention of infections, especially in the era of increasing threats from antibiotic-...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2021-04-01
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| Series: | mSphere |
| Online Access: | https://journals.asm.org/doi/10.1128/mSphere.00129-21 |
| _version_ | 1818972720336994304 |
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| author | Keane J. Dye Nancy J. Vogelaar Pablo Sobrado Zhaomin Yang |
| author_facet | Keane J. Dye Nancy J. Vogelaar Pablo Sobrado Zhaomin Yang |
| author_sort | Keane J. Dye |
| collection | DOAJ |
| description | Many bacterial pathogens use their type IV pili (T4P) to facilitate and maintain infection of a human host. Small chemical compounds that inhibit the production or assembly of T4P have promise in the treatment and prevention of infections, especially in the era of increasing threats from antibiotic-resistant bacteria. |
| first_indexed | 2024-12-20T15:12:45Z |
| format | Article |
| id | doaj.art-4cb177181c3544439641c6b5decdb39a |
| institution | Directory Open Access Journal |
| issn | 2379-5042 |
| language | English |
| last_indexed | 2024-12-20T15:12:45Z |
| publishDate | 2021-04-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mSphere |
| spelling | doaj.art-4cb177181c3544439641c6b5decdb39a2022-12-21T19:36:17ZengAmerican Society for MicrobiologymSphere2379-50422021-04-016210.1128/mSphere.00129-21High-Throughput Screen for Inhibitors of the Type IV Pilus Assembly ATPase PilBKeane J. Dye0Nancy J. Vogelaar1Pablo Sobrado2Zhaomin Yang3https://orcid.org/0000-0002-2044-6793Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, USAVirginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia, USAVirginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia, USADepartment of Biological Sciences, Virginia Tech, Blacksburg, Virginia, USAMany bacterial pathogens use their type IV pili (T4P) to facilitate and maintain infection of a human host. Small chemical compounds that inhibit the production or assembly of T4P have promise in the treatment and prevention of infections, especially in the era of increasing threats from antibiotic-resistant bacteria.https://journals.asm.org/doi/10.1128/mSphere.00129-21 |
| spellingShingle | Keane J. Dye Nancy J. Vogelaar Pablo Sobrado Zhaomin Yang High-Throughput Screen for Inhibitors of the Type IV Pilus Assembly ATPase PilB mSphere |
| title | High-Throughput Screen for Inhibitors of the Type IV Pilus Assembly ATPase PilB |
| title_full | High-Throughput Screen for Inhibitors of the Type IV Pilus Assembly ATPase PilB |
| title_fullStr | High-Throughput Screen for Inhibitors of the Type IV Pilus Assembly ATPase PilB |
| title_full_unstemmed | High-Throughput Screen for Inhibitors of the Type IV Pilus Assembly ATPase PilB |
| title_short | High-Throughput Screen for Inhibitors of the Type IV Pilus Assembly ATPase PilB |
| title_sort | high throughput screen for inhibitors of the type iv pilus assembly atpase pilb |
| url | https://journals.asm.org/doi/10.1128/mSphere.00129-21 |
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