Clinical presentation of brain metastases from endometrial carcinoma: A case series
Brain metastases from endometrial carcinoma are rare, however they do occur, and they are associated with an especially poor prognosis. There is evidence demonstrating improved outcomes with early diagnosis and subsequent multimodal treatment. This study therefore aims to review cases of brain metas...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-05-01
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| Series: | Gynecologic Oncology Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578919300268 |
| _version_ | 1818856832409534464 |
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| author | Marisa R. Moroney Lindsay J. Wheeler Bradley R. Corr |
| author_facet | Marisa R. Moroney Lindsay J. Wheeler Bradley R. Corr |
| author_sort | Marisa R. Moroney |
| collection | DOAJ |
| description | Brain metastases from endometrial carcinoma are rare, however they do occur, and they are associated with an especially poor prognosis. There is evidence demonstrating improved outcomes with early diagnosis and subsequent multimodal treatment. This study therefore aims to review cases of brain metastases from endometrial carcinoma with specific focus on clinical presentation and disease history. This retrospective case series evaluated all cases of brain metastases from endometrial carcinoma at a single institution over a seven-year period. A medical records search was performed using ICD codes for endometrial cancer, brain lesions and brain imaging. Analysis of patient and disease characteristics was performed with descriptive statistics. Twelve cases were identified. The majority of cases had intermediate or high-grade histology (97.7%), advanced stage disease (58.3%), and at least one prior disease recurrence (66.7%). Eleven of 12 cases (91.7%) had lung metastases diagnosed prior to brain metastases. All 12 cases had neurologic signs and symptoms present at time of brain metastases diagnosis; 14 different types of neurologic deficits were noted. Headache was the most common neurologic symptom (5/12, 41.7%), followed by focal weakness (3/12, 25.0%) and aphasia (3/12, 25.0%). In conclusion, clinical presentation at time of diagnosis of brain metastases consistently includes neurologic signs and symptoms with persistent headache being the most common. Endometrial cancer patients that present with new neurologic complaints or exam findings should be evaluated for brain metastases. Keywords: Endometrial cancer, brain metastases |
| first_indexed | 2024-12-19T08:30:46Z |
| format | Article |
| id | doaj.art-4cb1d46b877743ed86ebbf5eb5ce518c |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-12-19T08:30:46Z |
| publishDate | 2019-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-4cb1d46b877743ed86ebbf5eb5ce518c2022-12-21T20:29:12ZengElsevierGynecologic Oncology Reports2352-57892019-05-01287983Clinical presentation of brain metastases from endometrial carcinoma: A case seriesMarisa R. Moroney0Lindsay J. Wheeler1Bradley R. Corr2Corresponding author at: University of Colorado, Anschutz Medical Campus, School of Medicine, 12631 East 17th Avenue, B198-6, Aurora, CO 80045, United States.; University of Colorado Denver, Department of Obstetrics and Gynecology, Aurora, CO, United StatesUniversity of Colorado Denver, Department of Obstetrics and Gynecology, Aurora, CO, United StatesUniversity of Colorado Denver, Department of Obstetrics and Gynecology, Aurora, CO, United StatesBrain metastases from endometrial carcinoma are rare, however they do occur, and they are associated with an especially poor prognosis. There is evidence demonstrating improved outcomes with early diagnosis and subsequent multimodal treatment. This study therefore aims to review cases of brain metastases from endometrial carcinoma with specific focus on clinical presentation and disease history. This retrospective case series evaluated all cases of brain metastases from endometrial carcinoma at a single institution over a seven-year period. A medical records search was performed using ICD codes for endometrial cancer, brain lesions and brain imaging. Analysis of patient and disease characteristics was performed with descriptive statistics. Twelve cases were identified. The majority of cases had intermediate or high-grade histology (97.7%), advanced stage disease (58.3%), and at least one prior disease recurrence (66.7%). Eleven of 12 cases (91.7%) had lung metastases diagnosed prior to brain metastases. All 12 cases had neurologic signs and symptoms present at time of brain metastases diagnosis; 14 different types of neurologic deficits were noted. Headache was the most common neurologic symptom (5/12, 41.7%), followed by focal weakness (3/12, 25.0%) and aphasia (3/12, 25.0%). In conclusion, clinical presentation at time of diagnosis of brain metastases consistently includes neurologic signs and symptoms with persistent headache being the most common. Endometrial cancer patients that present with new neurologic complaints or exam findings should be evaluated for brain metastases. Keywords: Endometrial cancer, brain metastaseshttp://www.sciencedirect.com/science/article/pii/S2352578919300268 |
| spellingShingle | Marisa R. Moroney Lindsay J. Wheeler Bradley R. Corr Clinical presentation of brain metastases from endometrial carcinoma: A case series Gynecologic Oncology Reports |
| title | Clinical presentation of brain metastases from endometrial carcinoma: A case series |
| title_full | Clinical presentation of brain metastases from endometrial carcinoma: A case series |
| title_fullStr | Clinical presentation of brain metastases from endometrial carcinoma: A case series |
| title_full_unstemmed | Clinical presentation of brain metastases from endometrial carcinoma: A case series |
| title_short | Clinical presentation of brain metastases from endometrial carcinoma: A case series |
| title_sort | clinical presentation of brain metastases from endometrial carcinoma a case series |
| url | http://www.sciencedirect.com/science/article/pii/S2352578919300268 |
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