Efficacy of abdominal ultrasound inspection in the diagnosis and prognosis of neonatal necrotizing enterocolitis
OBJECTIVE: This study aimed to identify the most useful ultrasound (US) features associated with definite neonatal necrotizing enterocolitis (NEC) and their prognostic values, particularly the calculated markers combined with important features. METHODS: A total of 213 suspected NEC cases were coll...
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| Format: | Article |
| Language: | English |
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Elsevier España
2021-03-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322021000100242&tlng=en |
| _version_ | 1811229640420753408 |
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| author | Hong-Xia Gao Bin Yi Bao-Hong Mao Wei-Yang Li Xiang Bai Yue Zhang Jian-Ming Tang Pei-Qi Liu Kun Cheng |
| author_facet | Hong-Xia Gao Bin Yi Bao-Hong Mao Wei-Yang Li Xiang Bai Yue Zhang Jian-Ming Tang Pei-Qi Liu Kun Cheng |
| author_sort | Hong-Xia Gao |
| collection | DOAJ |
| description | OBJECTIVE: This study aimed to identify the most useful ultrasound (US) features associated with definite neonatal necrotizing enterocolitis (NEC) and their prognostic values, particularly the calculated markers combined with important features. METHODS: A total of 213 suspected NEC cases were collected from the neonatal department of our hospital from January 2015 to August 2017. Each infant received both X-ray and US examinations. RESULTS: No differences were found in sex composition and delivery modes between groups. NEC-positive neonates had poorer prognosis compared to negative ones. The NEC group showed a higher frequency of abnormal signals. US showed higher NEC-related frequencies in different parameters. A variable (named predictor in US [PUS]) with five features was constructed. For NEC diagnosis, this variable provided a much higher area under the curve Q2 (AUC) (0.965) than other parameters. In this model, PUS had a cutoff value of 0.376 with a 0.900 sensitivity and 0.922 specificity. In prognosis, the closest factors were selected to draw a receiver operating characteristic curve, as well as a novel calculated variable US prognostic (USPro) marker. USPro had a much higher AUC (0.86) than other single features and showed a cutoff value of 0.18145, with 0.75 sensitivity and 0.84 specificity. This variable had a weaker power in prognosis when compared with PUS in diagnosis. CONCLUSIONS: The application of abdominal color Doppler US can provide high accuracy and sensitivity in NEC diagnosis and also contribute to its prognosis, without induction of radiation. Suspected neonates should be examined using this technique as early as possible. |
| first_indexed | 2024-04-12T10:16:46Z |
| format | Article |
| id | doaj.art-4cb2dd322f8e49e496f01988720870c4 |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-04-12T10:16:46Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-4cb2dd322f8e49e496f01988720870c42022-12-22T03:37:11ZengElsevier EspañaClinics1980-53222021-03-017610.6061/clinics/2021/e1816Efficacy of abdominal ultrasound inspection in the diagnosis and prognosis of neonatal necrotizing enterocolitisHong-Xia Gaohttps://orcid.org/0000-0002-4130-8525Bin Yihttps://orcid.org/0000-0001-7961-7131Bao-Hong Maohttps://orcid.org/0000-0002-9795-9589Wei-Yang Lihttps://orcid.org/0000-0002-4931-6837Xiang Baihttps://orcid.org/0000-0002-0042-1679Yue Zhanghttps://orcid.org/0000-0003-1931-1207Jian-Ming Tanghttps://orcid.org/0000-0003-4138-3848Pei-Qi Liuhttps://orcid.org/0000-0002-3748-0285Kun Chenghttps://orcid.org/0000-0002-0547-7532OBJECTIVE: This study aimed to identify the most useful ultrasound (US) features associated with definite neonatal necrotizing enterocolitis (NEC) and their prognostic values, particularly the calculated markers combined with important features. METHODS: A total of 213 suspected NEC cases were collected from the neonatal department of our hospital from January 2015 to August 2017. Each infant received both X-ray and US examinations. RESULTS: No differences were found in sex composition and delivery modes between groups. NEC-positive neonates had poorer prognosis compared to negative ones. The NEC group showed a higher frequency of abnormal signals. US showed higher NEC-related frequencies in different parameters. A variable (named predictor in US [PUS]) with five features was constructed. For NEC diagnosis, this variable provided a much higher area under the curve Q2 (AUC) (0.965) than other parameters. In this model, PUS had a cutoff value of 0.376 with a 0.900 sensitivity and 0.922 specificity. In prognosis, the closest factors were selected to draw a receiver operating characteristic curve, as well as a novel calculated variable US prognostic (USPro) marker. USPro had a much higher AUC (0.86) than other single features and showed a cutoff value of 0.18145, with 0.75 sensitivity and 0.84 specificity. This variable had a weaker power in prognosis when compared with PUS in diagnosis. CONCLUSIONS: The application of abdominal color Doppler US can provide high accuracy and sensitivity in NEC diagnosis and also contribute to its prognosis, without induction of radiation. Suspected neonates should be examined using this technique as early as possible.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322021000100242&tlng=enNecrotizing EnterocolitisAbdominal UltrasoundX-rayNeonateDiagnosis |
| spellingShingle | Hong-Xia Gao Bin Yi Bao-Hong Mao Wei-Yang Li Xiang Bai Yue Zhang Jian-Ming Tang Pei-Qi Liu Kun Cheng Efficacy of abdominal ultrasound inspection in the diagnosis and prognosis of neonatal necrotizing enterocolitis Clinics Necrotizing Enterocolitis Abdominal Ultrasound X-ray Neonate Diagnosis |
| title | Efficacy of abdominal ultrasound inspection in the diagnosis and prognosis of neonatal necrotizing enterocolitis |
| title_full | Efficacy of abdominal ultrasound inspection in the diagnosis and prognosis of neonatal necrotizing enterocolitis |
| title_fullStr | Efficacy of abdominal ultrasound inspection in the diagnosis and prognosis of neonatal necrotizing enterocolitis |
| title_full_unstemmed | Efficacy of abdominal ultrasound inspection in the diagnosis and prognosis of neonatal necrotizing enterocolitis |
| title_short | Efficacy of abdominal ultrasound inspection in the diagnosis and prognosis of neonatal necrotizing enterocolitis |
| title_sort | efficacy of abdominal ultrasound inspection in the diagnosis and prognosis of neonatal necrotizing enterocolitis |
| topic | Necrotizing Enterocolitis Abdominal Ultrasound X-ray Neonate Diagnosis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322021000100242&tlng=en |
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