The impact of serum copper on the risk of epilepsy: a mendelian randomization study
Abstract Background The relationship between serum copper and epilepsy has been elucidated in observational studies. In this study, we aimed to explore the causal relationship between serum copper and epilepsy using Mendelian randomization (MR) analysis. Methods Single nucleotide polymorphisms (SNPs...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Acta Epileptologica |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42494-023-00126-3 |
| _version_ | 1797795447223353344 |
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| author | Shihao Chen Wenting Huang Qi Xu Tao He Mulan Zhang Huiqin Xu |
| author_facet | Shihao Chen Wenting Huang Qi Xu Tao He Mulan Zhang Huiqin Xu |
| author_sort | Shihao Chen |
| collection | DOAJ |
| description | Abstract Background The relationship between serum copper and epilepsy has been elucidated in observational studies. In this study, we aimed to explore the causal relationship between serum copper and epilepsy using Mendelian randomization (MR) analysis. Methods Single nucleotide polymorphisms (SNPs) associated with serum copper were used as instrumental variables for MR analysis to evaluate their causal effects on epilepsy. The main MR results were obtained by using the inverse variance weighting (IVW) method, supplemented by weighted median and MR-Egger regression. In addition, sensitivity analyses such as Cochran's Q test and pleiotropy test were used to assess these SNPs on epilepsy in terms of horizontal pleiotropy and heterogeneity. Results The IVW method revealed that the serum copper was associated with an increased risk of generalized epilepsy (OR= 1.07; 95% CI 1.01- 1.14; P = 0.032), and the sensitivity analysis further supports the robustness of the results. Conclusions The current study reveals a possible causal role for serum copper in increasing the risk of generalized epilepsy, which provide guidance for identifying potential risk factors for epilepsy. |
| first_indexed | 2024-03-13T03:18:03Z |
| format | Article |
| id | doaj.art-4cb3ad52b2674599b5cebab4ec1e8157 |
| institution | Directory Open Access Journal |
| issn | 2524-4434 |
| language | English |
| last_indexed | 2024-03-13T03:18:03Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Acta Epileptologica |
| spelling | doaj.art-4cb3ad52b2674599b5cebab4ec1e81572023-06-25T11:32:04ZengBMCActa Epileptologica2524-44342023-06-01511610.1186/s42494-023-00126-3The impact of serum copper on the risk of epilepsy: a mendelian randomization studyShihao Chen0Wenting Huang1Qi Xu2Tao He3Mulan Zhang4Huiqin Xu5Department of Neurology, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical UniversityAbstract Background The relationship between serum copper and epilepsy has been elucidated in observational studies. In this study, we aimed to explore the causal relationship between serum copper and epilepsy using Mendelian randomization (MR) analysis. Methods Single nucleotide polymorphisms (SNPs) associated with serum copper were used as instrumental variables for MR analysis to evaluate their causal effects on epilepsy. The main MR results were obtained by using the inverse variance weighting (IVW) method, supplemented by weighted median and MR-Egger regression. In addition, sensitivity analyses such as Cochran's Q test and pleiotropy test were used to assess these SNPs on epilepsy in terms of horizontal pleiotropy and heterogeneity. Results The IVW method revealed that the serum copper was associated with an increased risk of generalized epilepsy (OR= 1.07; 95% CI 1.01- 1.14; P = 0.032), and the sensitivity analysis further supports the robustness of the results. Conclusions The current study reveals a possible causal role for serum copper in increasing the risk of generalized epilepsy, which provide guidance for identifying potential risk factors for epilepsy.https://doi.org/10.1186/s42494-023-00126-3Serum copperEpilepsyMendelian randomizationGenome-wide association studiesSingle nucleotide polymorphisms |
| spellingShingle | Shihao Chen Wenting Huang Qi Xu Tao He Mulan Zhang Huiqin Xu The impact of serum copper on the risk of epilepsy: a mendelian randomization study Acta Epileptologica Serum copper Epilepsy Mendelian randomization Genome-wide association studies Single nucleotide polymorphisms |
| title | The impact of serum copper on the risk of epilepsy: a mendelian randomization study |
| title_full | The impact of serum copper on the risk of epilepsy: a mendelian randomization study |
| title_fullStr | The impact of serum copper on the risk of epilepsy: a mendelian randomization study |
| title_full_unstemmed | The impact of serum copper on the risk of epilepsy: a mendelian randomization study |
| title_short | The impact of serum copper on the risk of epilepsy: a mendelian randomization study |
| title_sort | impact of serum copper on the risk of epilepsy a mendelian randomization study |
| topic | Serum copper Epilepsy Mendelian randomization Genome-wide association studies Single nucleotide polymorphisms |
| url | https://doi.org/10.1186/s42494-023-00126-3 |
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