Sarcoidosis presenting with bicytopenia due to bone marrow granuloma
A 55-year-old homemaker presented with low-grade fever, fatigue, and loss of weight for 2 months. She had hepatosplenomegaly, mediastinal lymphadenopathy, cytopenias, hypercalcemia with normal parathormone, and noncaseating granulomas in bone marrow and lymph node biopsy. The patient was diagnosed t...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Iraqi Journal of Hematology |
| Subjects: | |
| Online Access: | http://www.ijhonline.org/article.asp?issn=2072-8069;year=2023;volume=12;issue=2;spage=210;epage=212;aulast=Abdulla |
| _version_ | 1797245327831465984 |
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| author | Mansoor C Abdulla |
| author_facet | Mansoor C Abdulla |
| author_sort | Mansoor C Abdulla |
| collection | DOAJ |
| description | A 55-year-old homemaker presented with low-grade fever, fatigue, and loss of weight for 2 months. She had hepatosplenomegaly, mediastinal lymphadenopathy, cytopenias, hypercalcemia with normal parathormone, and noncaseating granulomas in bone marrow and lymph node biopsy. The patient was diagnosed to have sarcoidosis with bone marrow involvement (histopathology showing noncaseating granuloma and high serum angiotensin-converting enzyme after ruling out other causes of granulomatous disorders by appropriate tests). She was managed with prednisolone 20 mg daily which was reduced and stopped after 3 months. On follow-up, she was asymptomatic and her blood counts were normal. Diagnosis of sarcoidosis should be considered always after ruling out other causes since it can mimic lymphoproliferative disorders and granulomatous infections. The initial presentation of sarcoidosis with bicytopenia due to bone marrow granulomas is extremely rare and physicians should have awareness of such atypical presentations. |
| first_indexed | 2024-04-24T19:25:09Z |
| format | Article |
| id | doaj.art-4cb44356db424104ab72d88baa67d5f3 |
| institution | Directory Open Access Journal |
| issn | 2072-8069 |
| language | English |
| last_indexed | 2024-04-24T19:25:09Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Iraqi Journal of Hematology |
| spelling | doaj.art-4cb44356db424104ab72d88baa67d5f32024-03-25T15:48:07ZengWolters Kluwer Medknow PublicationsIraqi Journal of Hematology2072-80692023-01-0112221021210.4103/ijh.ijh_62_23Sarcoidosis presenting with bicytopenia due to bone marrow granulomaMansoor C AbdullaA 55-year-old homemaker presented with low-grade fever, fatigue, and loss of weight for 2 months. She had hepatosplenomegaly, mediastinal lymphadenopathy, cytopenias, hypercalcemia with normal parathormone, and noncaseating granulomas in bone marrow and lymph node biopsy. The patient was diagnosed to have sarcoidosis with bone marrow involvement (histopathology showing noncaseating granuloma and high serum angiotensin-converting enzyme after ruling out other causes of granulomatous disorders by appropriate tests). She was managed with prednisolone 20 mg daily which was reduced and stopped after 3 months. On follow-up, she was asymptomatic and her blood counts were normal. Diagnosis of sarcoidosis should be considered always after ruling out other causes since it can mimic lymphoproliferative disorders and granulomatous infections. The initial presentation of sarcoidosis with bicytopenia due to bone marrow granulomas is extremely rare and physicians should have awareness of such atypical presentations.http://www.ijhonline.org/article.asp?issn=2072-8069;year=2023;volume=12;issue=2;spage=210;epage=212;aulast=Abdullabicytopeniabone marrow granulomasarcoidosis |
| spellingShingle | Mansoor C Abdulla Sarcoidosis presenting with bicytopenia due to bone marrow granuloma Iraqi Journal of Hematology bicytopenia bone marrow granuloma sarcoidosis |
| title | Sarcoidosis presenting with bicytopenia due to bone marrow granuloma |
| title_full | Sarcoidosis presenting with bicytopenia due to bone marrow granuloma |
| title_fullStr | Sarcoidosis presenting with bicytopenia due to bone marrow granuloma |
| title_full_unstemmed | Sarcoidosis presenting with bicytopenia due to bone marrow granuloma |
| title_short | Sarcoidosis presenting with bicytopenia due to bone marrow granuloma |
| title_sort | sarcoidosis presenting with bicytopenia due to bone marrow granuloma |
| topic | bicytopenia bone marrow granuloma sarcoidosis |
| url | http://www.ijhonline.org/article.asp?issn=2072-8069;year=2023;volume=12;issue=2;spage=210;epage=212;aulast=Abdulla |
| work_keys_str_mv | AT mansoorcabdulla sarcoidosispresentingwithbicytopeniaduetobonemarrowgranuloma |