<i>Lactobacillus gasseri</i> NK109 and Its Supplement Alleviate Cognitive Impairment in Mice by Modulating NF-κB Activation, BDNF Expression, and Gut Microbiota Composition
Aging-related gut microbiota dysbiosis initiates gut inflammation and microbiota dysbiosis, which induce the occurrence of psychiatric disorders including dementia. The alleviation of gut microbiota dysbiosis by probiotics is suggested to be able to alleviate psychiatric disorders including cognitiv...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/3/790 |
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| author | Soo-Won Yun Hee-Seo Park Yoon-Jung Shin Xiaoyang Ma Myung Joo Han Dong-Hyun Kim |
| author_facet | Soo-Won Yun Hee-Seo Park Yoon-Jung Shin Xiaoyang Ma Myung Joo Han Dong-Hyun Kim |
| author_sort | Soo-Won Yun |
| collection | DOAJ |
| description | Aging-related gut microbiota dysbiosis initiates gut inflammation and microbiota dysbiosis, which induce the occurrence of psychiatric disorders including dementia. The alleviation of gut microbiota dysbiosis by probiotics is suggested to be able to alleviate psychiatric disorders including cognitive impairment (CI). Therefore, to understand how probiotics could alleviate CI, we examined the effects of anti-inflammatory <i>Lactobacillus gasseri</i> NK109 and its supplement (NS, mixture of NK109 and soybean embryo ethanol extract) on cognitive function in aged (Ag), 5XFAD transgenic (Tg), or mildly cognition-impaired adult fecal microbiota (MCF)-transplanted mice. Oral administration of NK109 or NS decreased CI-like behaviors in Ag mice. Their treatments suppressed TNF-α and p16 expression and NF-κB-activated cell populations in the hippocampus and colon, while BDNF expression was induced. Moreover, they partially shifted the β-diversity of gut microbiota in Ag mice to those of young mice: they decreased Bifidobacteriaceae, Lactobacillaceae, and Helicobacteriaceae populations and increased Rikenellaceae and Prevotellaceae populations. Oral administration of NK109 or NS also reduced CI-like behaviors in Tg mice. Their treatments induced BDNF expression in the hippocampus, decreased hippocampal TNF-α and Aβ expression and hippocampal and colonic NF-κB-activated cell populations. NK109 and NS partially shifted the β-diversity of gut microbiota in Tg mice: they decreased Muribaculaceae and Rhodospiraceae populations and increased Helicobacteriaceae population. Oral administration of NK109 or NS decreased MCF transplantation-induced CI-like behaviors in mice. NK109 and NS increased hippocampal BDNF expression, while hippocampal and colonic TNF-α expression and NF-κB-activated cell populations decreased. These findings suggest that dementia can fluctuate the gut microbiota composition and NK109 and its supplement NS can alleviate CI with systemic inflammation by inducing BDNF expression and suppressing NF-κB activation and gut microbiota dysbiosis. |
| first_indexed | 2024-03-11T09:30:18Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T09:30:18Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-4cb8816e2b92465bbbb6851cc601e7e92023-11-16T17:42:00ZengMDPI AGNutrients2072-66432023-02-0115379010.3390/nu15030790<i>Lactobacillus gasseri</i> NK109 and Its Supplement Alleviate Cognitive Impairment in Mice by Modulating NF-κB Activation, BDNF Expression, and Gut Microbiota CompositionSoo-Won Yun0Hee-Seo Park1Yoon-Jung Shin2Xiaoyang Ma3Myung Joo Han4Dong-Hyun Kim5Department of Food and Nutrition, Kyung Hee University, Seoul 02447, Republic of KoreaNeurobiota Research Center, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of KoreaNeurobiota Research Center, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of KoreaNeurobiota Research Center, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of KoreaDepartment of Food and Nutrition, Kyung Hee University, Seoul 02447, Republic of KoreaNeurobiota Research Center, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of KoreaAging-related gut microbiota dysbiosis initiates gut inflammation and microbiota dysbiosis, which induce the occurrence of psychiatric disorders including dementia. The alleviation of gut microbiota dysbiosis by probiotics is suggested to be able to alleviate psychiatric disorders including cognitive impairment (CI). Therefore, to understand how probiotics could alleviate CI, we examined the effects of anti-inflammatory <i>Lactobacillus gasseri</i> NK109 and its supplement (NS, mixture of NK109 and soybean embryo ethanol extract) on cognitive function in aged (Ag), 5XFAD transgenic (Tg), or mildly cognition-impaired adult fecal microbiota (MCF)-transplanted mice. Oral administration of NK109 or NS decreased CI-like behaviors in Ag mice. Their treatments suppressed TNF-α and p16 expression and NF-κB-activated cell populations in the hippocampus and colon, while BDNF expression was induced. Moreover, they partially shifted the β-diversity of gut microbiota in Ag mice to those of young mice: they decreased Bifidobacteriaceae, Lactobacillaceae, and Helicobacteriaceae populations and increased Rikenellaceae and Prevotellaceae populations. Oral administration of NK109 or NS also reduced CI-like behaviors in Tg mice. Their treatments induced BDNF expression in the hippocampus, decreased hippocampal TNF-α and Aβ expression and hippocampal and colonic NF-κB-activated cell populations. NK109 and NS partially shifted the β-diversity of gut microbiota in Tg mice: they decreased Muribaculaceae and Rhodospiraceae populations and increased Helicobacteriaceae population. Oral administration of NK109 or NS decreased MCF transplantation-induced CI-like behaviors in mice. NK109 and NS increased hippocampal BDNF expression, while hippocampal and colonic TNF-α expression and NF-κB-activated cell populations decreased. These findings suggest that dementia can fluctuate the gut microbiota composition and NK109 and its supplement NS can alleviate CI with systemic inflammation by inducing BDNF expression and suppressing NF-κB activation and gut microbiota dysbiosis.https://www.mdpi.com/2072-6643/15/3/790<i>Lactobacillus gasseri</i>agingdementiafecal microbiota transplantationgut microbiota dysbiosisgut inflammation |
| spellingShingle | Soo-Won Yun Hee-Seo Park Yoon-Jung Shin Xiaoyang Ma Myung Joo Han Dong-Hyun Kim <i>Lactobacillus gasseri</i> NK109 and Its Supplement Alleviate Cognitive Impairment in Mice by Modulating NF-κB Activation, BDNF Expression, and Gut Microbiota Composition Nutrients <i>Lactobacillus gasseri</i> aging dementia fecal microbiota transplantation gut microbiota dysbiosis gut inflammation |
| title | <i>Lactobacillus gasseri</i> NK109 and Its Supplement Alleviate Cognitive Impairment in Mice by Modulating NF-κB Activation, BDNF Expression, and Gut Microbiota Composition |
| title_full | <i>Lactobacillus gasseri</i> NK109 and Its Supplement Alleviate Cognitive Impairment in Mice by Modulating NF-κB Activation, BDNF Expression, and Gut Microbiota Composition |
| title_fullStr | <i>Lactobacillus gasseri</i> NK109 and Its Supplement Alleviate Cognitive Impairment in Mice by Modulating NF-κB Activation, BDNF Expression, and Gut Microbiota Composition |
| title_full_unstemmed | <i>Lactobacillus gasseri</i> NK109 and Its Supplement Alleviate Cognitive Impairment in Mice by Modulating NF-κB Activation, BDNF Expression, and Gut Microbiota Composition |
| title_short | <i>Lactobacillus gasseri</i> NK109 and Its Supplement Alleviate Cognitive Impairment in Mice by Modulating NF-κB Activation, BDNF Expression, and Gut Microbiota Composition |
| title_sort | i lactobacillus gasseri i nk109 and its supplement alleviate cognitive impairment in mice by modulating nf κb activation bdnf expression and gut microbiota composition |
| topic | <i>Lactobacillus gasseri</i> aging dementia fecal microbiota transplantation gut microbiota dysbiosis gut inflammation |
| url | https://www.mdpi.com/2072-6643/15/3/790 |
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