Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism
We investigated the survival time of each clinical syndrome of frontotemporal dementia (FTD) and the impacts of behavioral and motor features on survival of FTD. A total of 216 patients with FTD [82 behavioral variant FTD (bvFTD), 78 semantic variant primary progressive aphasia (svPPA), 43 non-fluen...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/8/2260 |
| _version_ | 1797434487346298880 |
|---|---|
| author | Na-Yeon Jung Kee Hyung Park Sang Won Seo Hee Jin Kim Jee Hoon Roh Jae-Hong Lee Kyung Won Park Jay C. Kwon Jee Hyang Jeong Soo Jin Yoon Byeong C. Kim Young Ho Park SangYun Kim Jae-Won Jang Young Chul Youn Dong Won Yang Seong Hye Choi Duk L. Na Eun-Joo Kim |
| author_facet | Na-Yeon Jung Kee Hyung Park Sang Won Seo Hee Jin Kim Jee Hoon Roh Jae-Hong Lee Kyung Won Park Jay C. Kwon Jee Hyang Jeong Soo Jin Yoon Byeong C. Kim Young Ho Park SangYun Kim Jae-Won Jang Young Chul Youn Dong Won Yang Seong Hye Choi Duk L. Na Eun-Joo Kim |
| author_sort | Na-Yeon Jung |
| collection | DOAJ |
| description | We investigated the survival time of each clinical syndrome of frontotemporal dementia (FTD) and the impacts of behavioral and motor features on survival of FTD. A total of 216 patients with FTD [82 behavioral variant FTD (bvFTD), 78 semantic variant primary progressive aphasia (svPPA), 43 non-fluent/agrammatic variant PPA (nfvPPA), 13 FTD-motor neuron disease (MND)] were enrolled from 16 centers across Korea. Behaviors and parkinsonism were assessed using the Frontal Behavioral Inventory and Unified Parkinson’s Disease Rating Scale Part III, respectively. The Kaplan–Meier method was used for the survival analysis and the Cox proportional hazards model was applied for analysis of the effect of behavioral and motor symptoms on survival, after controlling vascular risk factors and cancer. An overall median survival of FTD was 12.1 years. The survival time from onset was shortest for FTD-MND and longest for svPPA. The median survival time of patients with bvFTD was unavailable but likely comparable to that of patients with nfvPPA. In the bvFTD group, negative behavioral symptoms and akinetic rigidity were significantly associated with survival. In the nfvPPA group, the presence of dysarthria had a negative impact on survival. These findings provide useful information to clinicians planning for care. |
| first_indexed | 2024-03-09T10:32:56Z |
| format | Article |
| id | doaj.art-4cc1e6135fe24cbd9bc6ef8fc80423e0 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T10:32:56Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-4cc1e6135fe24cbd9bc6ef8fc80423e02023-12-01T21:07:20ZengMDPI AGJournal of Clinical Medicine2077-03832022-04-01118226010.3390/jcm11082260Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and ParkinsonismNa-Yeon Jung0Kee Hyung Park1Sang Won Seo2Hee Jin Kim3Jee Hoon Roh4Jae-Hong Lee5Kyung Won Park6Jay C. Kwon7Jee Hyang Jeong8Soo Jin Yoon9Byeong C. Kim10Young Ho Park11SangYun Kim12Jae-Won Jang13Young Chul Youn14Dong Won Yang15Seong Hye Choi16Duk L. Na17Eun-Joo Kim18Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan 50612, KoreaDepartment of Neurology, College of Medicine, Gachon University Gil Hospital, Incheon 21565, KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDepartment of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, KoreaDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, KoreaDepartment of Neurology, Dong-A Medical Center, Dong-A University College of Medicine, Busan 49201, KoreaDepartment of Neurology, Changwon Fatima Hospital, Changwon 51394, KoreaDepartment of Neurology, Ewha Womans University College of Medicine, Seoul 07804, KoreaDepartment of Neurology, Eulji University Hospital, Eulji University School of Medicine, Daejeon 35233, KoreaDepartment of Neurology, Chonnam National University Medical School, Gwangju 61469, KoreaDepartment of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, KoreaDepartment of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, KoreaDepartment of Neurology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon 24289, KoreaDepartment of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul 06973, KoreaDepartment of Neurology, The Catholic University of Korea, Seoul St. Mary’s Hospital, Seoul 06591, KoreaDepartment of Neurology, Inha University School of Medicine, Incheon 22332, KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDepartment of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan 49241, KoreaWe investigated the survival time of each clinical syndrome of frontotemporal dementia (FTD) and the impacts of behavioral and motor features on survival of FTD. A total of 216 patients with FTD [82 behavioral variant FTD (bvFTD), 78 semantic variant primary progressive aphasia (svPPA), 43 non-fluent/agrammatic variant PPA (nfvPPA), 13 FTD-motor neuron disease (MND)] were enrolled from 16 centers across Korea. Behaviors and parkinsonism were assessed using the Frontal Behavioral Inventory and Unified Parkinson’s Disease Rating Scale Part III, respectively. The Kaplan–Meier method was used for the survival analysis and the Cox proportional hazards model was applied for analysis of the effect of behavioral and motor symptoms on survival, after controlling vascular risk factors and cancer. An overall median survival of FTD was 12.1 years. The survival time from onset was shortest for FTD-MND and longest for svPPA. The median survival time of patients with bvFTD was unavailable but likely comparable to that of patients with nfvPPA. In the bvFTD group, negative behavioral symptoms and akinetic rigidity were significantly associated with survival. In the nfvPPA group, the presence of dysarthria had a negative impact on survival. These findings provide useful information to clinicians planning for care.https://www.mdpi.com/2077-0383/11/8/2260frontotemporal dementiasurvivalabnormal behaviorparkinsonism |
| spellingShingle | Na-Yeon Jung Kee Hyung Park Sang Won Seo Hee Jin Kim Jee Hoon Roh Jae-Hong Lee Kyung Won Park Jay C. Kwon Jee Hyang Jeong Soo Jin Yoon Byeong C. Kim Young Ho Park SangYun Kim Jae-Won Jang Young Chul Youn Dong Won Yang Seong Hye Choi Duk L. Na Eun-Joo Kim Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism Journal of Clinical Medicine frontotemporal dementia survival abnormal behavior parkinsonism |
| title | Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism |
| title_full | Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism |
| title_fullStr | Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism |
| title_full_unstemmed | Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism |
| title_short | Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism |
| title_sort | survival in korean patients with frontotemporal dementia syndrome association with behavioral features and parkinsonism |
| topic | frontotemporal dementia survival abnormal behavior parkinsonism |
| url | https://www.mdpi.com/2077-0383/11/8/2260 |
| work_keys_str_mv | AT nayeonjung survivalinkoreanpatientswithfrontotemporaldementiasyndromeassociationwithbehavioralfeaturesandparkinsonism AT keehyungpark survivalinkoreanpatientswithfrontotemporaldementiasyndromeassociationwithbehavioralfeaturesandparkinsonism AT sangwonseo survivalinkoreanpatientswithfrontotemporaldementiasyndromeassociationwithbehavioralfeaturesandparkinsonism AT heejinkim survivalinkoreanpatientswithfrontotemporaldementiasyndromeassociationwithbehavioralfeaturesandparkinsonism AT jeehoonroh survivalinkoreanpatientswithfrontotemporaldementiasyndromeassociationwithbehavioralfeaturesandparkinsonism AT jaehonglee survivalinkoreanpatientswithfrontotemporaldementiasyndromeassociationwithbehavioralfeaturesandparkinsonism AT kyungwonpark survivalinkoreanpatientswithfrontotemporaldementiasyndromeassociationwithbehavioralfeaturesandparkinsonism AT jayckwon survivalinkoreanpatientswithfrontotemporaldementiasyndromeassociationwithbehavioralfeaturesandparkinsonism AT jeehyangjeong survivalinkoreanpatientswithfrontotemporaldementiasyndromeassociationwithbehavioralfeaturesandparkinsonism AT soojinyoon survivalinkoreanpatientswithfrontotemporaldementiasyndromeassociationwithbehavioralfeaturesandparkinsonism AT byeongckim survivalinkoreanpatientswithfrontotemporaldementiasyndromeassociationwithbehavioralfeaturesandparkinsonism AT younghopark survivalinkoreanpatientswithfrontotemporaldementiasyndromeassociationwithbehavioralfeaturesandparkinsonism AT sangyunkim survivalinkoreanpatientswithfrontotemporaldementiasyndromeassociationwithbehavioralfeaturesandparkinsonism AT jaewonjang survivalinkoreanpatientswithfrontotemporaldementiasyndromeassociationwithbehavioralfeaturesandparkinsonism AT youngchulyoun survivalinkoreanpatientswithfrontotemporaldementiasyndromeassociationwithbehavioralfeaturesandparkinsonism AT dongwonyang survivalinkoreanpatientswithfrontotemporaldementiasyndromeassociationwithbehavioralfeaturesandparkinsonism AT seonghyechoi survivalinkoreanpatientswithfrontotemporaldementiasyndromeassociationwithbehavioralfeaturesandparkinsonism AT duklna survivalinkoreanpatientswithfrontotemporaldementiasyndromeassociationwithbehavioralfeaturesandparkinsonism AT eunjookim survivalinkoreanpatientswithfrontotemporaldementiasyndromeassociationwithbehavioralfeaturesandparkinsonism |