pH sensing via bicarbonate-regulated ‘soluble’ adenylyl cyclase (sAC)
Soluble adenylyl cyclase (sAC) is a source of the second messenger cyclic adenosine 3',5' monophosphate (cAMP). sAC is directly regulated by bicarbonate (HCO3-) ions. In living cells, HCO3- ions are in nearly instantaneous equilibrium with carbon dioxide (CO2) and pH due to the ubiqu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-11-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00343/full |
| _version_ | 1830460378123862016 |
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| author | Nawreen eRahman Jochen eBuck Lonny Ray Levin |
| author_facet | Nawreen eRahman Jochen eBuck Lonny Ray Levin |
| author_sort | Nawreen eRahman |
| collection | DOAJ |
| description | Soluble adenylyl cyclase (sAC) is a source of the second messenger cyclic adenosine 3',5' monophosphate (cAMP). sAC is directly regulated by bicarbonate (HCO3-) ions. In living cells, HCO3- ions are in nearly instantaneous equilibrium with carbon dioxide (CO2) and pH due to the ubiquitous presence of carbonic anhydrases. Numerous biological processes are regulated by CO2, HCO3-, and/or pH, and in a number of these, sAC has been shown to function as a physiological CO2/HCO3/pH sensor. In this review, we detail the known pH sensing functions of sAC, and we discuss two highly-studied, pH-dependent pathways in which sAC might play a role. |
| first_indexed | 2024-12-21T11:11:03Z |
| format | Article |
| id | doaj.art-4cc2c69859df419f8d45a0d462e9c235 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-21T11:11:03Z |
| publishDate | 2013-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-4cc2c69859df419f8d45a0d462e9c2352022-12-21T19:06:05ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2013-11-01410.3389/fphys.2013.0034367934pH sensing via bicarbonate-regulated ‘soluble’ adenylyl cyclase (sAC)Nawreen eRahman0Jochen eBuck1Lonny Ray Levin2Weill Cornell Medical CollegeWeill Cornell Medical CollegeWeill Cornell Medical CollegeSoluble adenylyl cyclase (sAC) is a source of the second messenger cyclic adenosine 3',5' monophosphate (cAMP). sAC is directly regulated by bicarbonate (HCO3-) ions. In living cells, HCO3- ions are in nearly instantaneous equilibrium with carbon dioxide (CO2) and pH due to the ubiquitous presence of carbonic anhydrases. Numerous biological processes are regulated by CO2, HCO3-, and/or pH, and in a number of these, sAC has been shown to function as a physiological CO2/HCO3/pH sensor. In this review, we detail the known pH sensing functions of sAC, and we discuss two highly-studied, pH-dependent pathways in which sAC might play a role.http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00343/fullCarbonic AnhydrasesCyclic AMPpHbicarbonateSoluble adenylyl cyclase |
| spellingShingle | Nawreen eRahman Jochen eBuck Lonny Ray Levin pH sensing via bicarbonate-regulated ‘soluble’ adenylyl cyclase (sAC) Frontiers in Physiology Carbonic Anhydrases Cyclic AMP pH bicarbonate Soluble adenylyl cyclase |
| title | pH sensing via bicarbonate-regulated ‘soluble’ adenylyl cyclase (sAC) |
| title_full | pH sensing via bicarbonate-regulated ‘soluble’ adenylyl cyclase (sAC) |
| title_fullStr | pH sensing via bicarbonate-regulated ‘soluble’ adenylyl cyclase (sAC) |
| title_full_unstemmed | pH sensing via bicarbonate-regulated ‘soluble’ adenylyl cyclase (sAC) |
| title_short | pH sensing via bicarbonate-regulated ‘soluble’ adenylyl cyclase (sAC) |
| title_sort | ph sensing via bicarbonate regulated soluble adenylyl cyclase sac |
| topic | Carbonic Anhydrases Cyclic AMP pH bicarbonate Soluble adenylyl cyclase |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00343/full |
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