Filling the gaps in the research about second primary malignancies after bladder cancer: Focus on race and histology
PurposePrevious research has shown that bladder cancer has one of the highest incidences of developing a second primary malignancy. So, we designed this study to further examine this risk in light of race and histology.Patients and methodsUsing the surveillance, epidemiology, and end results (SEER)...
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1036722/full |
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| author | Belaydi Othmane Belaydi Othmane Zhenglin Yi Zhenglin Yi Chunyu Zhang Chunyu Zhang Jinbo Chen Jinbo Chen Xiongbing Zu Xiongbing Zu Benyi Fan Benyi Fan |
| author_facet | Belaydi Othmane Belaydi Othmane Zhenglin Yi Zhenglin Yi Chunyu Zhang Chunyu Zhang Jinbo Chen Jinbo Chen Xiongbing Zu Xiongbing Zu Benyi Fan Benyi Fan |
| author_sort | Belaydi Othmane |
| collection | DOAJ |
| description | PurposePrevious research has shown that bladder cancer has one of the highest incidences of developing a second primary malignancy. So, we designed this study to further examine this risk in light of race and histology.Patients and methodsUsing the surveillance, epidemiology, and end results (SEER) 18 registry, we retrospectively screened patients who had been diagnosed with bladder cancer between 2000 and 2018. We then tracked these survivors until a second primary cancer diagnosis, the conclusion of the trial, or their deaths. In addition to doing a competing risk analysis, we derived standardized incidence ratios (SIRs) and incidence rate ratios (IRRs) for SPMs by race and histology.ResultsA total of 162,335 patients with bladder cancer were included, and during follow-ups, a second primary cancer diagnosis was made in 31,746 of these patients. When the data were stratified by race, SIRs and IRRs for SPMs showed a significant difference: Asian/Pacific Islanders (APIs) had a more pronounced increase in SPMs (SIR: 2.15; p 0.05) than White and Black individuals who had an SIRs of 1.69 and 1.94, respectively; p 0.05. In terms of histology, the epithelial type was associated with an increase in SPMs across all three races, but more so in APIs (IRR: 3.51; 95% CI: 2.11–5.85; p 0.001).ConclusionWe found that race had an impact on both the type and risk of SPMs. Additionally, the likelihood of an SPM increases with the length of time between the two malignancies and the stage of the index malignancy. |
| first_indexed | 2024-04-12T08:50:32Z |
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| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-12T08:50:32Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Public Health |
| spelling | doaj.art-4cc2f4be1a6b4b1b94ecc868adf3e6c62022-12-22T03:39:36ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-11-011010.3389/fpubh.2022.10367221036722Filling the gaps in the research about second primary malignancies after bladder cancer: Focus on race and histologyBelaydi Othmane0Belaydi Othmane1Zhenglin Yi2Zhenglin Yi3Chunyu Zhang4Chunyu Zhang5Jinbo Chen6Jinbo Chen7Xiongbing Zu8Xiongbing Zu9Benyi Fan10Benyi Fan11Department of Urology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Urology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Urology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Urology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Urology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Urology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaPurposePrevious research has shown that bladder cancer has one of the highest incidences of developing a second primary malignancy. So, we designed this study to further examine this risk in light of race and histology.Patients and methodsUsing the surveillance, epidemiology, and end results (SEER) 18 registry, we retrospectively screened patients who had been diagnosed with bladder cancer between 2000 and 2018. We then tracked these survivors until a second primary cancer diagnosis, the conclusion of the trial, or their deaths. In addition to doing a competing risk analysis, we derived standardized incidence ratios (SIRs) and incidence rate ratios (IRRs) for SPMs by race and histology.ResultsA total of 162,335 patients with bladder cancer were included, and during follow-ups, a second primary cancer diagnosis was made in 31,746 of these patients. When the data were stratified by race, SIRs and IRRs for SPMs showed a significant difference: Asian/Pacific Islanders (APIs) had a more pronounced increase in SPMs (SIR: 2.15; p 0.05) than White and Black individuals who had an SIRs of 1.69 and 1.94, respectively; p 0.05. In terms of histology, the epithelial type was associated with an increase in SPMs across all three races, but more so in APIs (IRR: 3.51; 95% CI: 2.11–5.85; p 0.001).ConclusionWe found that race had an impact on both the type and risk of SPMs. Additionally, the likelihood of an SPM increases with the length of time between the two malignancies and the stage of the index malignancy.https://www.frontiersin.org/articles/10.3389/fpubh.2022.1036722/fullsecond primary malignanciesbladder cancerSEER databasehistologyrace |
| spellingShingle | Belaydi Othmane Belaydi Othmane Zhenglin Yi Zhenglin Yi Chunyu Zhang Chunyu Zhang Jinbo Chen Jinbo Chen Xiongbing Zu Xiongbing Zu Benyi Fan Benyi Fan Filling the gaps in the research about second primary malignancies after bladder cancer: Focus on race and histology Frontiers in Public Health second primary malignancies bladder cancer SEER database histology race |
| title | Filling the gaps in the research about second primary malignancies after bladder cancer: Focus on race and histology |
| title_full | Filling the gaps in the research about second primary malignancies after bladder cancer: Focus on race and histology |
| title_fullStr | Filling the gaps in the research about second primary malignancies after bladder cancer: Focus on race and histology |
| title_full_unstemmed | Filling the gaps in the research about second primary malignancies after bladder cancer: Focus on race and histology |
| title_short | Filling the gaps in the research about second primary malignancies after bladder cancer: Focus on race and histology |
| title_sort | filling the gaps in the research about second primary malignancies after bladder cancer focus on race and histology |
| topic | second primary malignancies bladder cancer SEER database histology race |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1036722/full |
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