Anti-inflammatory and Cytotoxic Triterpenes from the Rot Roots of Panax notoginseng
Abstract Four new protopanaxatriol-type triterpenes (1–2) and glucosides (3–4), were isolated from the rot roots of Panax notoginseng (Burk.) Chen, along with four known ones (5–8). Their structures were elucidated on the basis of extensive spectroscopic analysis (HRESIMS, NMR, UV, IR, and OR) and a...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2019-05-01
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| Series: | Natural Products and Bioprospecting |
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| Online Access: | http://link.springer.com/article/10.1007/s13659-019-0211-4 |
| _version_ | 1818852475373879296 |
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| author | Jia-Huan Shang Guo-Wei Xu Hong-Tao Zhu Dong Wang Chong-Ren Yang Ying-Jun Zhang |
| author_facet | Jia-Huan Shang Guo-Wei Xu Hong-Tao Zhu Dong Wang Chong-Ren Yang Ying-Jun Zhang |
| author_sort | Jia-Huan Shang |
| collection | DOAJ |
| description | Abstract Four new protopanaxatriol-type triterpenes (1–2) and glucosides (3–4), were isolated from the rot roots of Panax notoginseng (Burk.) Chen, along with four known ones (5–8). Their structures were elucidated on the basis of extensive spectroscopic analysis (HRESIMS, NMR, UV, IR, and OR) and acidic hydrolysis. The possible transformation pathway of these compounds were also speculated from ginsenoside Rg1. Compound 1, with a unique α,β-unsaturated ketene in its side chain, showed significant inhibitory effects against NO production on Murine macrophage cells (IC50 = 4.12 ± 0.20 μM) and comparable cytotoxicities against five human cancer cell lines (myeloid leukemia HL-60, lung cancer A-549 cells, hepatocellular carcinoma SMMC7721, breast cancer MCF-7, and colon cancer SW480) to positive control, cisplatin (DDP). Graphical Abstract |
| first_indexed | 2024-12-19T07:21:31Z |
| format | Article |
| id | doaj.art-4cc98d026a6a469e8532fded88749ff9 |
| institution | Directory Open Access Journal |
| issn | 2192-2195 2192-2209 |
| language | English |
| last_indexed | 2024-12-19T07:21:31Z |
| publishDate | 2019-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Natural Products and Bioprospecting |
| spelling | doaj.art-4cc98d026a6a469e8532fded88749ff92022-12-21T20:30:55ZengSpringerOpenNatural Products and Bioprospecting2192-21952192-22092019-05-019428729510.1007/s13659-019-0211-4Anti-inflammatory and Cytotoxic Triterpenes from the Rot Roots of Panax notoginsengJia-Huan Shang0Guo-Wei Xu1Hong-Tao Zhu2Dong Wang3Chong-Ren Yang4Ying-Jun Zhang5State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of SciencesAbstract Four new protopanaxatriol-type triterpenes (1–2) and glucosides (3–4), were isolated from the rot roots of Panax notoginseng (Burk.) Chen, along with four known ones (5–8). Their structures were elucidated on the basis of extensive spectroscopic analysis (HRESIMS, NMR, UV, IR, and OR) and acidic hydrolysis. The possible transformation pathway of these compounds were also speculated from ginsenoside Rg1. Compound 1, with a unique α,β-unsaturated ketene in its side chain, showed significant inhibitory effects against NO production on Murine macrophage cells (IC50 = 4.12 ± 0.20 μM) and comparable cytotoxicities against five human cancer cell lines (myeloid leukemia HL-60, lung cancer A-549 cells, hepatocellular carcinoma SMMC7721, breast cancer MCF-7, and colon cancer SW480) to positive control, cisplatin (DDP). Graphical Abstracthttp://link.springer.com/article/10.1007/s13659-019-0211-4Panax notoginsengRot rootTriterpenes and saponinsInhibition on NO productionCytotoxicity |
| spellingShingle | Jia-Huan Shang Guo-Wei Xu Hong-Tao Zhu Dong Wang Chong-Ren Yang Ying-Jun Zhang Anti-inflammatory and Cytotoxic Triterpenes from the Rot Roots of Panax notoginseng Natural Products and Bioprospecting Panax notoginseng Rot root Triterpenes and saponins Inhibition on NO production Cytotoxicity |
| title | Anti-inflammatory and Cytotoxic Triterpenes from the Rot Roots of Panax notoginseng |
| title_full | Anti-inflammatory and Cytotoxic Triterpenes from the Rot Roots of Panax notoginseng |
| title_fullStr | Anti-inflammatory and Cytotoxic Triterpenes from the Rot Roots of Panax notoginseng |
| title_full_unstemmed | Anti-inflammatory and Cytotoxic Triterpenes from the Rot Roots of Panax notoginseng |
| title_short | Anti-inflammatory and Cytotoxic Triterpenes from the Rot Roots of Panax notoginseng |
| title_sort | anti inflammatory and cytotoxic triterpenes from the rot roots of panax notoginseng |
| topic | Panax notoginseng Rot root Triterpenes and saponins Inhibition on NO production Cytotoxicity |
| url | http://link.springer.com/article/10.1007/s13659-019-0211-4 |
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