SDF-1α upregulation by atorvastatin in rats with acute myocardial infarction via nitric oxide production confers anti-inflammatory and anti-apoptotic effects
<p>Abstract</p> <p>Background</p> <p>The effects of atorvastatin on SDF-1α expression under acute myocardial infarction (AMI) are still unclear. Therefore, our present study is to investigate the roles and mechanisms of atorvastatin treatment on SDF-1α expression in rat...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-11-01
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| Series: | Journal of Biomedical Science |
| Subjects: | |
| Online Access: | http://www.jbiomedsci.com/content/19/1/99 |
| _version_ | 1818235247088631808 |
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| author | Qiu Ruofeng Cai Anping Dong Yugang Zhou Yingling Yu Danqing Huang Yuli Zheng Dongdan Rao Shaoqi Feng Yingqing Mai Weiyi |
| author_facet | Qiu Ruofeng Cai Anping Dong Yugang Zhou Yingling Yu Danqing Huang Yuli Zheng Dongdan Rao Shaoqi Feng Yingqing Mai Weiyi |
| author_sort | Qiu Ruofeng |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The effects of atorvastatin on SDF-1α expression under acute myocardial infarction (AMI) are still unclear. Therefore, our present study is to investigate the roles and mechanisms of atorvastatin treatment on SDF-1α expression in rats with AMI.</p> <p>Methods</p> <p>Male Sprague–Dawley rats were underwent permanent coronary artery ligation and randomly assigned into four groups as follow: blank control (B), atorvastatin (A), atorvastatin plus L-NAME (A+L-NAME), and atorvastatin plus AMD3100 (A+AMD3100). Rats underwent similar procedure but without ligation were used as group sham operated (S). Atorvastatin (10mg/Kg/d body weight) was administrated by gavage to rats in three atorvastatin treated groups, and L-NAME (40mg/Kg/d body weight) or AMD3100 (5mg/Kg/d body weight) was given to group A+L-NAME or A+AMD3100, respectively.</p> <p>Results</p> <p>Comparing with group B, NO production, SDF-1α and CXCR4 expression were significantly up-regulated in three atorvastatin treated groups at the seventh day. However, the increments of SDF-1α and CXCR4 expression in group A+L-NAME were reduced when NO production was inhibited by L-NAME. Anti-inflammatory and anti-apoptotic effects of atorvastatin were offset either by decrease of SDF-1α and CXCR4 expression (by L-NAME) or blockage of SDF-1α coupling with CXCR4 (by AMD3100). Expression of STAT3, a cardioprotective factor mediating SDF-1α/CXCR4 axis induced cardiac protection, was up-regulated most significantly in group A. The effects of atorvastatin therapy on cardiac function were also abrogated either when SDF-1α and CXCR4 expression was diminished or the coupling of SDF-1α with CXCR4 was blocked.</p> <p>Conclusion</p> <p>SDF-1α upregulation by atorvastatin in rats with AMI was, at least partially, via the eNOS/NO dependent pathway, and SDF-1α upregulation and SDF-1α coupling with CXCR4 conferred anti-inflammatory and anti-apoptotic effects under AMI setting which we speculated that ultimately contributed to cardiac function improvement.</p> |
| first_indexed | 2024-12-12T11:50:56Z |
| format | Article |
| id | doaj.art-4ccbc5fdc90245c1a4441460f86348d9 |
| institution | Directory Open Access Journal |
| issn | 1021-7770 1423-0127 |
| language | English |
| last_indexed | 2024-12-12T11:50:56Z |
| publishDate | 2012-11-01 |
| publisher | BMC |
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| spelling | doaj.art-4ccbc5fdc90245c1a4441460f86348d92022-12-22T00:25:19ZengBMCJournal of Biomedical Science1021-77701423-01272012-11-011919910.1186/1423-0127-19-99SDF-1α upregulation by atorvastatin in rats with acute myocardial infarction via nitric oxide production confers anti-inflammatory and anti-apoptotic effectsQiu RuofengCai AnpingDong YugangZhou YinglingYu DanqingHuang YuliZheng DongdanRao ShaoqiFeng YingqingMai Weiyi<p>Abstract</p> <p>Background</p> <p>The effects of atorvastatin on SDF-1α expression under acute myocardial infarction (AMI) are still unclear. Therefore, our present study is to investigate the roles and mechanisms of atorvastatin treatment on SDF-1α expression in rats with AMI.</p> <p>Methods</p> <p>Male Sprague–Dawley rats were underwent permanent coronary artery ligation and randomly assigned into four groups as follow: blank control (B), atorvastatin (A), atorvastatin plus L-NAME (A+L-NAME), and atorvastatin plus AMD3100 (A+AMD3100). Rats underwent similar procedure but without ligation were used as group sham operated (S). Atorvastatin (10mg/Kg/d body weight) was administrated by gavage to rats in three atorvastatin treated groups, and L-NAME (40mg/Kg/d body weight) or AMD3100 (5mg/Kg/d body weight) was given to group A+L-NAME or A+AMD3100, respectively.</p> <p>Results</p> <p>Comparing with group B, NO production, SDF-1α and CXCR4 expression were significantly up-regulated in three atorvastatin treated groups at the seventh day. However, the increments of SDF-1α and CXCR4 expression in group A+L-NAME were reduced when NO production was inhibited by L-NAME. Anti-inflammatory and anti-apoptotic effects of atorvastatin were offset either by decrease of SDF-1α and CXCR4 expression (by L-NAME) or blockage of SDF-1α coupling with CXCR4 (by AMD3100). Expression of STAT3, a cardioprotective factor mediating SDF-1α/CXCR4 axis induced cardiac protection, was up-regulated most significantly in group A. The effects of atorvastatin therapy on cardiac function were also abrogated either when SDF-1α and CXCR4 expression was diminished or the coupling of SDF-1α with CXCR4 was blocked.</p> <p>Conclusion</p> <p>SDF-1α upregulation by atorvastatin in rats with AMI was, at least partially, via the eNOS/NO dependent pathway, and SDF-1α upregulation and SDF-1α coupling with CXCR4 conferred anti-inflammatory and anti-apoptotic effects under AMI setting which we speculated that ultimately contributed to cardiac function improvement.</p>http://www.jbiomedsci.com/content/19/1/99Acute myocardial infarctionAtorvastatinStromal cell derived factor-1alpha |
| spellingShingle | Qiu Ruofeng Cai Anping Dong Yugang Zhou Yingling Yu Danqing Huang Yuli Zheng Dongdan Rao Shaoqi Feng Yingqing Mai Weiyi SDF-1α upregulation by atorvastatin in rats with acute myocardial infarction via nitric oxide production confers anti-inflammatory and anti-apoptotic effects Journal of Biomedical Science Acute myocardial infarction Atorvastatin Stromal cell derived factor-1alpha |
| title | SDF-1α upregulation by atorvastatin in rats with acute myocardial infarction via nitric oxide production confers anti-inflammatory and anti-apoptotic effects |
| title_full | SDF-1α upregulation by atorvastatin in rats with acute myocardial infarction via nitric oxide production confers anti-inflammatory and anti-apoptotic effects |
| title_fullStr | SDF-1α upregulation by atorvastatin in rats with acute myocardial infarction via nitric oxide production confers anti-inflammatory and anti-apoptotic effects |
| title_full_unstemmed | SDF-1α upregulation by atorvastatin in rats with acute myocardial infarction via nitric oxide production confers anti-inflammatory and anti-apoptotic effects |
| title_short | SDF-1α upregulation by atorvastatin in rats with acute myocardial infarction via nitric oxide production confers anti-inflammatory and anti-apoptotic effects |
| title_sort | sdf 1α upregulation by atorvastatin in rats with acute myocardial infarction via nitric oxide production confers anti inflammatory and anti apoptotic effects |
| topic | Acute myocardial infarction Atorvastatin Stromal cell derived factor-1alpha |
| url | http://www.jbiomedsci.com/content/19/1/99 |
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