Weaker Effects of the Fourth Dose of BNT162b2 SARS-CoV-2 Vaccine on the Elderly Human Population
The vaccines presently available are less effective in older people due to senescence of their immune systems. We measured the antibody responses of 42 adults living in nursing homes after the third and the fourth doses of an mRNA vaccine and found that the strain (BA.2 and BA.2.75: from 64 to 128,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/6/1095 |
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| author | Chloé Dimeglio Isabelle Da-Silva Marion Porcheron Marie-Pierre Panero Laetitia Staes Pauline Trémeaux Hélène Villars Jacques Izopet |
| author_facet | Chloé Dimeglio Isabelle Da-Silva Marion Porcheron Marie-Pierre Panero Laetitia Staes Pauline Trémeaux Hélène Villars Jacques Izopet |
| author_sort | Chloé Dimeglio |
| collection | DOAJ |
| description | The vaccines presently available are less effective in older people due to senescence of their immune systems. We measured the antibody responses of 42 adults living in nursing homes after the third and the fourth doses of an mRNA vaccine and found that the strain (BA.2 and BA.2.75: from 64 to 128, BA.5: from 16 to 32, BQ.1.1: from 16 to 64 among the uninfected) influenced the effect of the fourth dose of vaccine on neutralizing antibodies. The fourth dose also increased binding antibodies (from 1036 BAU/mL to 5371 BAU/mL among the uninfected, from 3700 BAU/mL to 6773 BAU/mL among the BA.5 infected). This effect was less significant than that of the third dose of vaccine for both neutralizing (BA.2: from 8 to 128, BA.5: from 2 to 16, BA.2.75: from 8 to 64, BQ.1.1: from 2 to 16) and binding antibodies (from 139.8 BAU/mL to 2293 BAU/mL). However, the fourth dose attained the 5000 BAU/mL threshold conferring approximately 80% protection against a SARS-CoV-2 BA.2 infection in most individuals, unlike the third. |
| first_indexed | 2024-03-11T01:50:55Z |
| format | Article |
| id | doaj.art-4ccc663033b84f4394b39942d443da12 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-11T01:50:55Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-4ccc663033b84f4394b39942d443da122023-11-18T12:59:09ZengMDPI AGVaccines2076-393X2023-06-01116109510.3390/vaccines11061095Weaker Effects of the Fourth Dose of BNT162b2 SARS-CoV-2 Vaccine on the Elderly Human PopulationChloé Dimeglio0Isabelle Da-Silva1Marion Porcheron2Marie-Pierre Panero3Laetitia Staes4Pauline Trémeaux5Hélène Villars6Jacques Izopet7Virology Laboratory, CHU Toulouse, Hôpital Purpan, 31300 Toulouse, FranceVirology Laboratory, CHU Toulouse, Hôpital Purpan, 31300 Toulouse, FranceVirology Laboratory, CHU Toulouse, Hôpital Purpan, 31300 Toulouse, FranceMedical School, Toulouse III University, 31000 Toulouse, FranceVirology Laboratory, CHU Toulouse, Hôpital Purpan, 31300 Toulouse, FranceVirology Laboratory, CHU Toulouse, Hôpital Purpan, 31300 Toulouse, FranceInserm UMR 1295: Center for Research in Population Health (CERPOP), Department of Epidemiology and Public Health, Toulouse, University of Toulouse III, 31073 Toulouse, FranceVirology Laboratory, CHU Toulouse, Hôpital Purpan, 31300 Toulouse, FranceThe vaccines presently available are less effective in older people due to senescence of their immune systems. We measured the antibody responses of 42 adults living in nursing homes after the third and the fourth doses of an mRNA vaccine and found that the strain (BA.2 and BA.2.75: from 64 to 128, BA.5: from 16 to 32, BQ.1.1: from 16 to 64 among the uninfected) influenced the effect of the fourth dose of vaccine on neutralizing antibodies. The fourth dose also increased binding antibodies (from 1036 BAU/mL to 5371 BAU/mL among the uninfected, from 3700 BAU/mL to 6773 BAU/mL among the BA.5 infected). This effect was less significant than that of the third dose of vaccine for both neutralizing (BA.2: from 8 to 128, BA.5: from 2 to 16, BA.2.75: from 8 to 64, BQ.1.1: from 2 to 16) and binding antibodies (from 139.8 BAU/mL to 2293 BAU/mL). However, the fourth dose attained the 5000 BAU/mL threshold conferring approximately 80% protection against a SARS-CoV-2 BA.2 infection in most individuals, unlike the third.https://www.mdpi.com/2076-393X/11/6/1095vaccinationvulnerable populationSARS-CoV-2immune monitoring |
| spellingShingle | Chloé Dimeglio Isabelle Da-Silva Marion Porcheron Marie-Pierre Panero Laetitia Staes Pauline Trémeaux Hélène Villars Jacques Izopet Weaker Effects of the Fourth Dose of BNT162b2 SARS-CoV-2 Vaccine on the Elderly Human Population Vaccines vaccination vulnerable population SARS-CoV-2 immune monitoring |
| title | Weaker Effects of the Fourth Dose of BNT162b2 SARS-CoV-2 Vaccine on the Elderly Human Population |
| title_full | Weaker Effects of the Fourth Dose of BNT162b2 SARS-CoV-2 Vaccine on the Elderly Human Population |
| title_fullStr | Weaker Effects of the Fourth Dose of BNT162b2 SARS-CoV-2 Vaccine on the Elderly Human Population |
| title_full_unstemmed | Weaker Effects of the Fourth Dose of BNT162b2 SARS-CoV-2 Vaccine on the Elderly Human Population |
| title_short | Weaker Effects of the Fourth Dose of BNT162b2 SARS-CoV-2 Vaccine on the Elderly Human Population |
| title_sort | weaker effects of the fourth dose of bnt162b2 sars cov 2 vaccine on the elderly human population |
| topic | vaccination vulnerable population SARS-CoV-2 immune monitoring |
| url | https://www.mdpi.com/2076-393X/11/6/1095 |
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