Pharmacokinetics and Main Metabolites of Anwulignan in Mice

Pharmacokinetics and Main Metabolites of Anwulignan in Mice

Anwulignan is a representative component of Chinese traditional medicine Schisandra sphenanthera, with strong pharmacological activities. However, there are few reports on its pharmacokinetics and metabolites in the body. In this study, a metabolomic method based on UHPLC-Q-Orbitrap-MS was used to s...

Full description

Bibliographic Details
Main Authors:	Cong Chen, Yanbo Feng, Han Li, Hao Lin, Shu Jing, He Li, Chunmei Wang, Jianguang Chen, Jinghui Sun
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-07-01
Series:	Frontiers in Pharmacology
Subjects:	Schisandra sphenanthera anwulignan pharmacokinetics metabolites UHPLC-Q-Orbitrap-MS
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.929177/full

Similar Items

Pharmacokinetics and Metabolite Profiling of Trepibutone in Rats Using Ultra-High Performance Liquid Chromatography Combined With Hybrid Quadrupole-Orbitrap and Triple Quadrupole Mass Spectrometers
by: Zhi Sun, et al.
Published: (2019-11-01)

The complete mitochondrial genome of Schisandra sphenanthera (Schisandraceae)
by: Xianxian Yu, et al.
Published: (2018-07-01)

Pharmacokinetics and Metabolism Research of Shenkang Injection in Rats Based on UHPLC-MS/MS and UHPLC-Q-Orbitrap HRMS
by: Jiang X, et al.
Published: (2020-05-01)

A Comprehensive Review of the Main Lignan Components of Schisandra chinensis (North Wu Wei Zi) and Schisandra sphenanthera (South Wu Wei Zi) and the Lignan-Induced Drug-Drug Interactions Based on the Inhibition of Cytochrome P450 and P-Glycoprotein Activities
by: Feng Zhang, et al.
Published: (2022-03-01)

Study on Pharmacokinetics and Metabolic Profiles of Novel Potential PLK-1 Inhibitors by UHPLC-MS/MS Combined with UHPLC-Q-Orbitrap/HRMS
by: Lin Wang, et al.
Published: (2023-03-01)

In Vivo Metabolite Profiling of DMU-212 in Apc<sup>Min/+</sup> Mice Using UHPLC-Q/Orbitrap/LTQ MS
by: Jing Li, et al.
Published: (2023-04-01)

Comparative pharmacokinetics of six major compounds in normal and insomnia rats after oral administration of Ziziphi Spinosae Semen aqueous extract
by: Chenhui Du, et al.
Published: (2020-08-01)

The Metabolites and Mechanism Analysis of Genistin against Hyperlipidemia via the UHPLC-Q-Exactive Orbitrap Mass Spectrometer and Metabolomics
by: Zhe Li, et al.
Published: (2023-02-01)

Plant Triterpenoids Regulate Endophyte Community to Promote Medicinal Plant <i>Schisandra sphenanthera</i> Growth and Metabolites Accumulation
by: Chuan You, et al.
Published: (2021-09-01)

Development of a UHPLC-MS/MS-based data-mining method for rapid profiling and characterization of magnolol metabolites in rat urine and plasma
by: Beibei Ma, et al.
Published: (2021-02-01)

The Application of Ultra-High-Performance Liquid Chromatography Coupled with a LTQ-Orbitrap Mass Technique to Reveal the Dynamic Accumulation of Secondary Metabolites in Licorice under ABA Stress
by: Da Li, et al.
Published: (2017-10-01)

Anti-asthmatic fraction screening and mechanisms prediction of Schisandrae Sphenantherae Fructus based on a combined approach
by: Fan Li, et al.
Published: (2022-09-01)

Microbial-Transferred Metabolites and Improvement of Biological Activities of Green Tea Catechins by Human Gut Microbiota
by: You Su, et al.
Published: (2024-03-01)

Quality differentiation method of similar phytomedicines with high sugar content based on the sugar-marker: Taking Schisandrae Chinensis Fructus and Schisandrae Sphenantherae Fructus as an example
by: Hongmei Zhang, et al.
Published: (2022-04-01)

Identification and Pharmacokinetic Studies on Complanatuside and Its Major Metabolites in Rats by UHPLC-Q-TOF-MS/MS and LC-MS/MS
by: Yu-Feng Yao, et al.
Published: (2018-12-01)

Detection and characterization of the metabolites of rutaecarpine in rats based on ultra-high-performance liquid chromatography with linear ion trap-Orbitrap mass spectrometer
by: Wei Cai, et al.
Published: (2017-01-01)

Use of an UHPLC-MS/MS Method for Determination of Kuraridin and Characterization of Its Metabolites in Rat Plasma after Oral Administration
by: Yi Liu, et al.
Published: (2018-01-01)

Identification and mechanism prediction of mulberroside A metabolites in vivo and in vitro of rats using an integrated strategy of UHPLC-Q-Exactive Plus Orbitrap MS and network pharmacology
by: Xiao Zhang, et al.
Published: (2022-09-01)

Comprehensive characterization of narirutin metabolites in vitro and in vivo based on Analogous-Core recursion analysis strategy using UHPLC-Q-Exactive Orbitrap MS/MS
by: Shuyi Song, et al.
Published: (2023-08-01)

Protective effect of Anwulignan against D-galactose-induced hepatic injury through activating p38 MAPK–Nrf2–HO-1 pathway in mice
by: Gao J, et al.
Published: (2018-10-01)

Secondary Metabolite Profiling of Species of the Genus Usnea by UHPLC-ESI-OT-MS-MS
by: Francisco Salgado, et al.
Published: (2017-12-01)

Comparative characterization of the metabolites of phloretin and phlorizin in rats using UHPLC-Q-Exactive Orbitrap mass spectrometer
by: Haoran Li, et al.
Published: (2024-03-01)

Hepatoprotective effect of tiliroside and characterization of its metabolites in human hepatocytes by ultra-high performance liquid chromatography-high resolution mass spectrometry
by: Wenwen Zhang, et al.
Published: (2023-08-01)

The Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Pinostrobin in Rats: Ultra-High-Performance Liquid Chromatography Coupled With Linear Trap Quadrupole Orbitrap Mass Spectrometry Studies
by: Xiaoya Sun, et al.
Published: (2020-11-01)

Schisandra sphenanthera extract (Wuzhi Tablet) protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice
by: Xuezhen Zeng, et al.
Published: (2017-09-01)

Metabolites Identification and Mechanism Prediction of Neobavaisoflavone In Vitro and In Vivo of Rats through UHPLC-Q-Exactive Plus Orbitrap MS Integrated Network Pharmacology
by: Linlin Li, et al.
Published: (2022-12-01)

Metabolomics analysis reveals the effect of fermentation on the chemical composition and antioxidant activity of Paeonia lactiflora Root
by: Tianyu Wang, et al.
Published: (2024-04-01)

ANO1-downregulation induced by schisandrathera D: a novel therapeutic target for the treatment of prostate and oral cancers
by: SeonJu Park, et al.
Published: (2023-05-01)

An analysis of the nutritional effects of Schisandra chinensis components based on mass spectrometry technology
by: Mengzhen Jia, et al.
Published: (2023-07-01)

Nontargeted Metabolomics as a Screening Tool for Estimating Bioactive Metabolites in the Extracts of 50 Indigenous Korean Plants
by: Se Rin Choi, et al.
Published: (2021-08-01)

Comprehensive analysis of resveratrol metabolites in rats using ultra high performance liquid chromatography coupled with high resolution mass spectrometry
by: Zihan Liu, et al.
Published: (2020-09-01)

The Analytical Strategy of “Ion Induction and Deduction Based on Net-Hubs” for the Comprehensive Characterization of Naringenin Metabolites In Vivo and In Vitro Using a UHPLC-Q-Exactive Orbitrap Mass Spectrometer
by: Yi-Fang Cui, et al.
Published: (2022-10-01)

Identification of the tannins in traditional Chinese medicine Paeoniae Radix Alba by UHPLC-Q-Exactive Orbitrap MS
by: Pei Xiong, et al.
Published: (2021-11-01)

Systematic screening and characterization of cardamonin metabolites using UHPLC-Q-Exactive Orbitrap MS after oral administration to rats
by: Fan Dong, et al.
Published: (2020-12-01)

UPLC-Q-Orbitrap HRMS Combined with Network Pharmacology to Analyze the Material Basis and Mechanism of Schisandrae chinensis in the Treatment of Non-alcoholic Fatty Liver
by: Yuanyuan REN, et al.
Published: (2022-03-01)

Tissue-specific transcriptome and metabolome analyses reveal candidate genes for lignan biosynthesis in the medicinal plant Schisandra sphenanthera
by: Boshi Sun, et al.
Published: (2023-10-01)

Development of a UHPLC-MS/MS method for the determination of quercetin in milk and its application to a pharmacokinetic study
by: Gbylik-Sikorska Małgorzata, et al.
Published: (2019-03-01)

Systematically Characterize the Anti-Alzheimer’s Disease Mechanism of Lignans from <i>S. chinensis</i> Based on In-Vivo Ingredient Analysis and Target-Network Pharmacology Strategy by UHPLC–Q-TOF-MS
by: Mengying Wei, et al.
Published: (2019-03-01)

Chemical Profile Determination and Quantitative Analysis of Components in Oryeong-san Using UHPLC-Q-Orbitrap-MS and UPLC-TQ-MS/MS
by: Seol Jang, et al.
Published: (2023-04-01)

UHPLC-MS Metabolome Fingerprinting: The Isolation of Main Compounds and Antioxidant Activity of the Andean Species Tetraglochin ameghinoi (Speg.) Speg.
by: Lorena Luna, et al.
Published: (2018-03-01)