Promoting OCD WEllness and resilience (POWER) study: Rationale, design, and methods
Obsessive-compulsive disorder (OCD) affects 1–2% of children and is associated with functional impairment and diminished quality of life. Several treatments are efficacious: cognitive behavioral therapy (CBT) with exposure and response prevention, serotonin reuptake inhibitor (SRI) monotherapy, and...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Psychiatry Research Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772598723000107 |
| _version_ | 1797810559508283392 |
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| author | Jessica D. Leuchter Minjee Kook Daniel A. Geller Alyssa G. Hertz Jessica Garcia Erika S. Trent Tracey Dibbs Ogechi Onyeka Wayne K. Goodman Andrew G. Guzick Andrew D. Wiese Amanda D. Palo Brent J. Small H. Blair Simpson Lauren K. Havel Sohail A. Nibras Kirti Saxena Eric A. Storch |
| author_facet | Jessica D. Leuchter Minjee Kook Daniel A. Geller Alyssa G. Hertz Jessica Garcia Erika S. Trent Tracey Dibbs Ogechi Onyeka Wayne K. Goodman Andrew G. Guzick Andrew D. Wiese Amanda D. Palo Brent J. Small H. Blair Simpson Lauren K. Havel Sohail A. Nibras Kirti Saxena Eric A. Storch |
| author_sort | Jessica D. Leuchter |
| collection | DOAJ |
| description | Obsessive-compulsive disorder (OCD) affects 1–2% of children and is associated with functional impairment and diminished quality of life. Several treatments are efficacious: cognitive behavioral therapy (CBT) with exposure and response prevention, serotonin reuptake inhibitor (SRI) monotherapy, and combined treatment (SRI + CBT). Expert clinician-informed practice parameters suggest that youth with mild to moderate OCD should be treated initially with CBT yet SRIs are frequently employed as the first-line intervention or in combination with psychotherapy in applied practice. Empirical data to guide SRI discontinuation in pediatric OCD are very limited. This study, Promoting OCD Wellness and Resiliency (POWER), aims to address this gap through a two phase, double-blinded, placebo-controlled, randomized controlled non-inferiority trial with the purpose of evaluating whether youth with OCD on an SRI can discontinue their medication after successful CBT augmentation and maintain wellness for a period of 24 weeks during which they receive maintenance CBT that models standard-of-care. In this paper we describe the rationale and methodological design of the POWER study. |
| first_indexed | 2024-03-13T07:10:43Z |
| format | Article |
| id | doaj.art-4ccccfd3051e4720ab94bc54e5e81fa6 |
| institution | Directory Open Access Journal |
| issn | 2772-5987 |
| language | English |
| last_indexed | 2024-03-13T07:10:43Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Psychiatry Research Communications |
| spelling | doaj.art-4ccccfd3051e4720ab94bc54e5e81fa62023-06-06T04:00:59ZengElsevierPsychiatry Research Communications2772-59872023-06-0132100111Promoting OCD WEllness and resilience (POWER) study: Rationale, design, and methodsJessica D. Leuchter0Minjee Kook1Daniel A. Geller2Alyssa G. Hertz3Jessica Garcia4Erika S. Trent5Tracey Dibbs6Ogechi Onyeka7Wayne K. Goodman8Andrew G. Guzick9Andrew D. Wiese10Amanda D. Palo11Brent J. Small12H. Blair Simpson13Lauren K. Havel14Sohail A. Nibras15Kirti Saxena16Eric A. Storch17Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USADepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USADepartment of Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA, USADepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USADepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA; Department of Psychology, University of Houston, Houston, TX, USADepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA; Department of Psychology, University of Houston, Houston, TX, USADepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USADepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USADepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USADepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USADepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USADepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USASchool of Aging Studies, University of South Florida, Tampa, FL, USADepartment of Psychiatry, Columbia University Medical Center, USADepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA; Texas Children's Hospital, Houston, TX, USADepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA; Texas Children's Hospital, Houston, TX, USADepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA; Texas Children's Hospital, Houston, TX, USADepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA; Corresponding author.Obsessive-compulsive disorder (OCD) affects 1–2% of children and is associated with functional impairment and diminished quality of life. Several treatments are efficacious: cognitive behavioral therapy (CBT) with exposure and response prevention, serotonin reuptake inhibitor (SRI) monotherapy, and combined treatment (SRI + CBT). Expert clinician-informed practice parameters suggest that youth with mild to moderate OCD should be treated initially with CBT yet SRIs are frequently employed as the first-line intervention or in combination with psychotherapy in applied practice. Empirical data to guide SRI discontinuation in pediatric OCD are very limited. This study, Promoting OCD Wellness and Resiliency (POWER), aims to address this gap through a two phase, double-blinded, placebo-controlled, randomized controlled non-inferiority trial with the purpose of evaluating whether youth with OCD on an SRI can discontinue their medication after successful CBT augmentation and maintain wellness for a period of 24 weeks during which they receive maintenance CBT that models standard-of-care. In this paper we describe the rationale and methodological design of the POWER study.http://www.sciencedirect.com/science/article/pii/S2772598723000107Obsessive-compulsive disorderSerotonin reuptake inhibitorsCognitive behavioral therapyRandomized controlled trialChildrenYouth |
| spellingShingle | Jessica D. Leuchter Minjee Kook Daniel A. Geller Alyssa G. Hertz Jessica Garcia Erika S. Trent Tracey Dibbs Ogechi Onyeka Wayne K. Goodman Andrew G. Guzick Andrew D. Wiese Amanda D. Palo Brent J. Small H. Blair Simpson Lauren K. Havel Sohail A. Nibras Kirti Saxena Eric A. Storch Promoting OCD WEllness and resilience (POWER) study: Rationale, design, and methods Psychiatry Research Communications Obsessive-compulsive disorder Serotonin reuptake inhibitors Cognitive behavioral therapy Randomized controlled trial Children Youth |
| title | Promoting OCD WEllness and resilience (POWER) study: Rationale, design, and methods |
| title_full | Promoting OCD WEllness and resilience (POWER) study: Rationale, design, and methods |
| title_fullStr | Promoting OCD WEllness and resilience (POWER) study: Rationale, design, and methods |
| title_full_unstemmed | Promoting OCD WEllness and resilience (POWER) study: Rationale, design, and methods |
| title_short | Promoting OCD WEllness and resilience (POWER) study: Rationale, design, and methods |
| title_sort | promoting ocd wellness and resilience power study rationale design and methods |
| topic | Obsessive-compulsive disorder Serotonin reuptake inhibitors Cognitive behavioral therapy Randomized controlled trial Children Youth |
| url | http://www.sciencedirect.com/science/article/pii/S2772598723000107 |
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