Association Between Plasma Lipoprotein Levels and Aortic Valve Calcification Among Patients with Aortic Valve Replacement Surgery: A Retrospective Study
Tingting Tao, Junnan Zheng, Yu Han, Qiqi Yang, Yiming Ni, Liang Ma Department of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of ChinaCorrespondence: Liang Ma, Department of Cardiovascular Surgery, The First Affi...
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Dove Medical Press
2022-05-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/association-between-plasma-lipoprotein-levels-and-aortic-valve-calcifi-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1818206560508182528 |
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| author | Tao T Zheng J Han Y Yang Q Ni Y Ma L |
| author_facet | Tao T Zheng J Han Y Yang Q Ni Y Ma L |
| author_sort | Tao T |
| collection | DOAJ |
| description | Tingting Tao, Junnan Zheng, Yu Han, Qiqi Yang, Yiming Ni, Liang Ma Department of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of ChinaCorrespondence: Liang Ma, Department of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 79#, Qingchun Road, Hangzhou, Zhejiang, 310003, People’s Republic of China, Tel +86 571 87236841, Fax +86 571 87236843, Email ml1402@zju.edu.cnObjective: Calcific aortic valve disease (CAVD) is a prevalent type of valvular heart disease, its association with dyslipidemia remains controversial.Methods: Of 449 CAVD patients who underwent aortic valve replacement, 228 formed the aortic valve calcification (AVC) group, and 221 were the non-calcification group. We retrospectively reviewed the preoperative and one-year postoperative plasma lipoprotein levels of both and performed a logistic regression to evaluate the factors associated with AVC.Results: Preoperatively, AVC patients had significantly higher coronary heart disease (43.0% vs 24.9%, p< 0.001), peripheral vascular disease (41.7% vs 26.2%, p< 0.001), and heart failure rates (63.6% vs 47.1%, p< 0.001), and a higher level of total cholesterol (4.1± 0.9 vs 3.9± 0.8 mmol/L, p=0.032) and very low-density cholesterol (0.6 (0.4– 0.7) vs 0.5 (0.3– 0.7) mmol/L, p=0.054). Echocardiography revealed a significant difference of aortic stenosis in both AVC and non-AVC groups (p< 0.05), and also identified aortic regurgitation (AR) with a significant difference between these two groups (p=0.003). The peak transaortic jet velocity, peak transaortic gradient, and mean transaortic gradient were significantly higher in the calcification group (all p< 0.001), but the aortic valve area (0.7 (0.5– 1.0) vs 4 (0.9– 4.5) cm2; p< 0.001) was smaller. Age (OR=1.023), total cholesterol (OR=1.272), and mean transaortic gradient (OR=1.182) were AVC risk factors. A larger aortic valve area (OR=0.010) were protective factors. The one-year mortality and perivalvular leakage rates were significantly higher in the calcification group.Conclusion: Total cholesterol was significantly higher in AVC patients and may be an AVC risk factor along with age and mean transaortic gradient. AVC patients had a relatively poorer outcome within one year.Keywords: aortic valve calcification, total cholesterol, plasma lipoprotein levels, low-density lipoprotein, aortic valve replacement |
| first_indexed | 2024-12-12T04:14:58Z |
| format | Article |
| id | doaj.art-4cd051cfced24f20b399a8f3a804cf4d |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-12-12T04:14:58Z |
| publishDate | 2022-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-4cd051cfced24f20b399a8f3a804cf4d2022-12-22T00:38:30ZengDove Medical PressInternational Journal of General Medicine1178-70742022-05-01Volume 154665467375060Association Between Plasma Lipoprotein Levels and Aortic Valve Calcification Among Patients with Aortic Valve Replacement Surgery: A Retrospective StudyTao TZheng JHan YYang QNi YMa LTingting Tao, Junnan Zheng, Yu Han, Qiqi Yang, Yiming Ni, Liang Ma Department of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of ChinaCorrespondence: Liang Ma, Department of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 79#, Qingchun Road, Hangzhou, Zhejiang, 310003, People’s Republic of China, Tel +86 571 87236841, Fax +86 571 87236843, Email ml1402@zju.edu.cnObjective: Calcific aortic valve disease (CAVD) is a prevalent type of valvular heart disease, its association with dyslipidemia remains controversial.Methods: Of 449 CAVD patients who underwent aortic valve replacement, 228 formed the aortic valve calcification (AVC) group, and 221 were the non-calcification group. We retrospectively reviewed the preoperative and one-year postoperative plasma lipoprotein levels of both and performed a logistic regression to evaluate the factors associated with AVC.Results: Preoperatively, AVC patients had significantly higher coronary heart disease (43.0% vs 24.9%, p< 0.001), peripheral vascular disease (41.7% vs 26.2%, p< 0.001), and heart failure rates (63.6% vs 47.1%, p< 0.001), and a higher level of total cholesterol (4.1± 0.9 vs 3.9± 0.8 mmol/L, p=0.032) and very low-density cholesterol (0.6 (0.4– 0.7) vs 0.5 (0.3– 0.7) mmol/L, p=0.054). Echocardiography revealed a significant difference of aortic stenosis in both AVC and non-AVC groups (p< 0.05), and also identified aortic regurgitation (AR) with a significant difference between these two groups (p=0.003). The peak transaortic jet velocity, peak transaortic gradient, and mean transaortic gradient were significantly higher in the calcification group (all p< 0.001), but the aortic valve area (0.7 (0.5– 1.0) vs 4 (0.9– 4.5) cm2; p< 0.001) was smaller. Age (OR=1.023), total cholesterol (OR=1.272), and mean transaortic gradient (OR=1.182) were AVC risk factors. A larger aortic valve area (OR=0.010) were protective factors. The one-year mortality and perivalvular leakage rates were significantly higher in the calcification group.Conclusion: Total cholesterol was significantly higher in AVC patients and may be an AVC risk factor along with age and mean transaortic gradient. AVC patients had a relatively poorer outcome within one year.Keywords: aortic valve calcification, total cholesterol, plasma lipoprotein levels, low-density lipoprotein, aortic valve replacementhttps://www.dovepress.com/association-between-plasma-lipoprotein-levels-and-aortic-valve-calcifi-peer-reviewed-fulltext-article-IJGMaortic valve calcificationtotal cholesterolplasma lipoprotein levelslow-density lipoproteinaortic valve replacement |
| spellingShingle | Tao T Zheng J Han Y Yang Q Ni Y Ma L Association Between Plasma Lipoprotein Levels and Aortic Valve Calcification Among Patients with Aortic Valve Replacement Surgery: A Retrospective Study International Journal of General Medicine aortic valve calcification total cholesterol plasma lipoprotein levels low-density lipoprotein aortic valve replacement |
| title | Association Between Plasma Lipoprotein Levels and Aortic Valve Calcification Among Patients with Aortic Valve Replacement Surgery: A Retrospective Study |
| title_full | Association Between Plasma Lipoprotein Levels and Aortic Valve Calcification Among Patients with Aortic Valve Replacement Surgery: A Retrospective Study |
| title_fullStr | Association Between Plasma Lipoprotein Levels and Aortic Valve Calcification Among Patients with Aortic Valve Replacement Surgery: A Retrospective Study |
| title_full_unstemmed | Association Between Plasma Lipoprotein Levels and Aortic Valve Calcification Among Patients with Aortic Valve Replacement Surgery: A Retrospective Study |
| title_short | Association Between Plasma Lipoprotein Levels and Aortic Valve Calcification Among Patients with Aortic Valve Replacement Surgery: A Retrospective Study |
| title_sort | association between plasma lipoprotein levels and aortic valve calcification among patients with aortic valve replacement surgery a retrospective study |
| topic | aortic valve calcification total cholesterol plasma lipoprotein levels low-density lipoprotein aortic valve replacement |
| url | https://www.dovepress.com/association-between-plasma-lipoprotein-levels-and-aortic-valve-calcifi-peer-reviewed-fulltext-article-IJGM |
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