Association between digestive diseases and sarcopenia among Chinese middle-aged and older adults: a prospective cohort study based on nationally representative survey
ObjectivesPatients with digestive diseases frequently suffer from dyspepsia and malabsorption, which may lead to muscle loss due to malnutrition. However, it is not clear whether digestive diseases are associated with sarcopenia. This study aims to explore the longitudinal association between digest...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1097860/full |
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| author | Guanghui Cui Guanghui Cui Shaojie Li Shaojie Li Hui Ye Hui Ye Yao Yang Yao Yang Yingming Chu Yingming Chu Xiaofen Jia Xiaofen Jia Yue Feng Yue Feng Miaomiao Lin Miaomiao Lin Xuezhi Zhang Xuezhi Zhang |
| author_facet | Guanghui Cui Guanghui Cui Shaojie Li Shaojie Li Hui Ye Hui Ye Yao Yang Yao Yang Yingming Chu Yingming Chu Xiaofen Jia Xiaofen Jia Yue Feng Yue Feng Miaomiao Lin Miaomiao Lin Xuezhi Zhang Xuezhi Zhang |
| author_sort | Guanghui Cui |
| collection | DOAJ |
| description | ObjectivesPatients with digestive diseases frequently suffer from dyspepsia and malabsorption, which may lead to muscle loss due to malnutrition. However, it is not clear whether digestive diseases are associated with sarcopenia. This study aims to explore the longitudinal association between digestive diseases and sarcopenia in middle-aged and older adults based on a nationally representative survey from China.MethodsWe used a prospective cohort study including 7,025 middle-aged and older adults aged ≥45 years from the 2011 to 2015 waves China Health and Retirement Longitudinal Study (CHARLS). Digestive diseases were identified using self-report. The assessment of sarcopenia was based on the Asian Working Group for Sarcopenia 2019 Consensus and included three components of muscle strength, physical performance, and muscle mass. Cox hazards regression was used to examine the association between digestive diseases and sarcopenia.ResultsThe prevalence of digestive diseases and the incidence of sarcopenia in middle-aged and older adults were 22.6% (95% CI = 21.6–23.6%) and 8.5% (95% CI = 7.8–9.1%). After adjusting for 15 covariates composed of three sets (demographic characteristics, lifestyles, and health status), digestive diseases were associated with a higher risk of sarcopenia (HR = 1.241, 95% CI = 1.034–1.490, P < 0.05). The associations were more pronounced among men, older adults aged 60–79, rural residents, and married people. In addition, the association between digestive diseases and sarcopenia was robust in the sensitivity analysis.ConclusionDigestive diseases were associated with an increased risk of sarcopenia in middle-aged and older adults aged ≥45 years. Early intervention of digestive diseases may help to reduce the incidence of sarcopenia in middle-aged and older adults. |
| first_indexed | 2024-03-13T01:17:24Z |
| format | Article |
| id | doaj.art-4cd274a2a8b140849a6041f3b4ace156 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-13T01:17:24Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-4cd274a2a8b140849a6041f3b4ace1562023-07-05T08:42:21ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-07-011010.3389/fnut.2023.10978601097860Association between digestive diseases and sarcopenia among Chinese middle-aged and older adults: a prospective cohort study based on nationally representative surveyGuanghui Cui0Guanghui Cui1Shaojie Li2Shaojie Li3Hui Ye4Hui Ye5Yao Yang6Yao Yang7Yingming Chu8Yingming Chu9Xiaofen Jia10Xiaofen Jia11Yue Feng12Yue Feng13Miaomiao Lin14Miaomiao Lin15Xuezhi Zhang16Xuezhi Zhang17Department of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, Beijing, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Peking University, Beijing, ChinaSchool of Public Health, Peking University, Beijing, ChinaChina Center for Health Development Studies, Peking University, Beijing, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, Beijing, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Peking University, Beijing, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, Beijing, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Peking University, Beijing, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, Beijing, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Peking University, Beijing, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, Beijing, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Peking University, Beijing, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, Beijing, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Peking University, Beijing, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, Beijing, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Peking University, Beijing, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, Beijing, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Peking University, Beijing, ChinaObjectivesPatients with digestive diseases frequently suffer from dyspepsia and malabsorption, which may lead to muscle loss due to malnutrition. However, it is not clear whether digestive diseases are associated with sarcopenia. This study aims to explore the longitudinal association between digestive diseases and sarcopenia in middle-aged and older adults based on a nationally representative survey from China.MethodsWe used a prospective cohort study including 7,025 middle-aged and older adults aged ≥45 years from the 2011 to 2015 waves China Health and Retirement Longitudinal Study (CHARLS). Digestive diseases were identified using self-report. The assessment of sarcopenia was based on the Asian Working Group for Sarcopenia 2019 Consensus and included three components of muscle strength, physical performance, and muscle mass. Cox hazards regression was used to examine the association between digestive diseases and sarcopenia.ResultsThe prevalence of digestive diseases and the incidence of sarcopenia in middle-aged and older adults were 22.6% (95% CI = 21.6–23.6%) and 8.5% (95% CI = 7.8–9.1%). After adjusting for 15 covariates composed of three sets (demographic characteristics, lifestyles, and health status), digestive diseases were associated with a higher risk of sarcopenia (HR = 1.241, 95% CI = 1.034–1.490, P < 0.05). The associations were more pronounced among men, older adults aged 60–79, rural residents, and married people. In addition, the association between digestive diseases and sarcopenia was robust in the sensitivity analysis.ConclusionDigestive diseases were associated with an increased risk of sarcopenia in middle-aged and older adults aged ≥45 years. Early intervention of digestive diseases may help to reduce the incidence of sarcopenia in middle-aged and older adults.https://www.frontiersin.org/articles/10.3389/fnut.2023.1097860/fulldigestive diseasessarcopeniamiddle-aged and older adultsChinaCHARLS |
| spellingShingle | Guanghui Cui Guanghui Cui Shaojie Li Shaojie Li Hui Ye Hui Ye Yao Yang Yao Yang Yingming Chu Yingming Chu Xiaofen Jia Xiaofen Jia Yue Feng Yue Feng Miaomiao Lin Miaomiao Lin Xuezhi Zhang Xuezhi Zhang Association between digestive diseases and sarcopenia among Chinese middle-aged and older adults: a prospective cohort study based on nationally representative survey Frontiers in Nutrition digestive diseases sarcopenia middle-aged and older adults China CHARLS |
| title | Association between digestive diseases and sarcopenia among Chinese middle-aged and older adults: a prospective cohort study based on nationally representative survey |
| title_full | Association between digestive diseases and sarcopenia among Chinese middle-aged and older adults: a prospective cohort study based on nationally representative survey |
| title_fullStr | Association between digestive diseases and sarcopenia among Chinese middle-aged and older adults: a prospective cohort study based on nationally representative survey |
| title_full_unstemmed | Association between digestive diseases and sarcopenia among Chinese middle-aged and older adults: a prospective cohort study based on nationally representative survey |
| title_short | Association between digestive diseases and sarcopenia among Chinese middle-aged and older adults: a prospective cohort study based on nationally representative survey |
| title_sort | association between digestive diseases and sarcopenia among chinese middle aged and older adults a prospective cohort study based on nationally representative survey |
| topic | digestive diseases sarcopenia middle-aged and older adults China CHARLS |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1097860/full |
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