Mucosal Leishmaniasis in Travelers with Leishmania braziliensis Complex Returning to Israel
Mucosal leishmaniasis (ML) is a complication of New World cutaneous leishmaniasis (CL) caused mainly by Leishmania (Viannia) braziliensis. This retrospective study investigated all cases of ML caused by L. (V.) braziliensis in a tertiary medical center in Israel, evaluating the risk factors, clinica...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2019-04-01
|
| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/25/4/18-0239_article |
| _version_ | 1819108959613616128 |
|---|---|
| author | Michal Solomon Nadav Sahar Felix Pavlotzky Aviv Barzilai Charles L. Jaffe Abedelmajeed Nasereddin Eli Schwartz |
| author_facet | Michal Solomon Nadav Sahar Felix Pavlotzky Aviv Barzilai Charles L. Jaffe Abedelmajeed Nasereddin Eli Schwartz |
| author_sort | Michal Solomon |
| collection | DOAJ |
| description | Mucosal leishmaniasis (ML) is a complication of New World cutaneous leishmaniasis (CL) caused mainly by Leishmania (Viannia) braziliensis. This retrospective study investigated all cases of ML caused by L. (V.) braziliensis in a tertiary medical center in Israel, evaluating the risk factors, clinical presentations, diagnosis, treatment, and outcome of mucosal involvement in ML caused by L. (V.) braziliensis in travelers returning to Israel. During 1993–2015, a total of 145 New World CL cases were seen in travelers returning from Bolivia; among them, 17 (11.7%) developed ML. Nasopharyngeal symptoms developed 0–3 years (median 8 months) after exposure. The only significant risk factor for developing ML was the absence of previous systemic treatment. Among untreated patients, 41% developed ML, compared with only 3% of treated patients (p = 0.005). Systemic treatment for CL seems to be a protective factor against developing ML. |
| first_indexed | 2024-12-22T03:18:13Z |
| format | Article |
| id | doaj.art-4cd3133107394ad3ac94d6f58e4532de |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-22T03:18:13Z |
| publishDate | 2019-04-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-4cd3133107394ad3ac94d6f58e4532de2022-12-21T18:40:46ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592019-04-0125464264810.3201/eid2504.180239Mucosal Leishmaniasis in Travelers with Leishmania braziliensis Complex Returning to IsraelMichal SolomonNadav SaharFelix PavlotzkyAviv BarzilaiCharles L. JaffeAbedelmajeed NasereddinEli SchwartzMucosal leishmaniasis (ML) is a complication of New World cutaneous leishmaniasis (CL) caused mainly by Leishmania (Viannia) braziliensis. This retrospective study investigated all cases of ML caused by L. (V.) braziliensis in a tertiary medical center in Israel, evaluating the risk factors, clinical presentations, diagnosis, treatment, and outcome of mucosal involvement in ML caused by L. (V.) braziliensis in travelers returning to Israel. During 1993–2015, a total of 145 New World CL cases were seen in travelers returning from Bolivia; among them, 17 (11.7%) developed ML. Nasopharyngeal symptoms developed 0–3 years (median 8 months) after exposure. The only significant risk factor for developing ML was the absence of previous systemic treatment. Among untreated patients, 41% developed ML, compared with only 3% of treated patients (p = 0.005). Systemic treatment for CL seems to be a protective factor against developing ML.https://wwwnc.cdc.gov/eid/article/25/4/18-0239_articleleishmaniasisLeishmania braziliensisLeishmania viannia braziliensismucosal leishmaniasiscutaneous leishmaniasistravelers |
| spellingShingle | Michal Solomon Nadav Sahar Felix Pavlotzky Aviv Barzilai Charles L. Jaffe Abedelmajeed Nasereddin Eli Schwartz Mucosal Leishmaniasis in Travelers with Leishmania braziliensis Complex Returning to Israel Emerging Infectious Diseases leishmaniasis Leishmania braziliensis Leishmania viannia braziliensis mucosal leishmaniasis cutaneous leishmaniasis travelers |
| title | Mucosal Leishmaniasis in Travelers with Leishmania braziliensis Complex Returning to Israel |
| title_full | Mucosal Leishmaniasis in Travelers with Leishmania braziliensis Complex Returning to Israel |
| title_fullStr | Mucosal Leishmaniasis in Travelers with Leishmania braziliensis Complex Returning to Israel |
| title_full_unstemmed | Mucosal Leishmaniasis in Travelers with Leishmania braziliensis Complex Returning to Israel |
| title_short | Mucosal Leishmaniasis in Travelers with Leishmania braziliensis Complex Returning to Israel |
| title_sort | mucosal leishmaniasis in travelers with leishmania braziliensis complex returning to israel |
| topic | leishmaniasis Leishmania braziliensis Leishmania viannia braziliensis mucosal leishmaniasis cutaneous leishmaniasis travelers |
| url | https://wwwnc.cdc.gov/eid/article/25/4/18-0239_article |
| work_keys_str_mv | AT michalsolomon mucosalleishmaniasisintravelerswithleishmaniabraziliensiscomplexreturningtoisrael AT nadavsahar mucosalleishmaniasisintravelerswithleishmaniabraziliensiscomplexreturningtoisrael AT felixpavlotzky mucosalleishmaniasisintravelerswithleishmaniabraziliensiscomplexreturningtoisrael AT avivbarzilai mucosalleishmaniasisintravelerswithleishmaniabraziliensiscomplexreturningtoisrael AT charlesljaffe mucosalleishmaniasisintravelerswithleishmaniabraziliensiscomplexreturningtoisrael AT abedelmajeednasereddin mucosalleishmaniasisintravelerswithleishmaniabraziliensiscomplexreturningtoisrael AT elischwartz mucosalleishmaniasisintravelerswithleishmaniabraziliensiscomplexreturningtoisrael |