Sulf-2, a Proangiogenic Heparan Sulfate Endosulfatase, Is Upregulated in Breast Cancer

Sulf-2, a Proangiogenic Heparan Sulfate Endosulfatase, Is Upregulated in Breast Cancer

Sulf-2 is an endosulfatase with activity against glucosamine-6-sulfate modifications within subregions of intact heparin. The enzyme has the potential to modify the sulfation status of extracellular heparan sulfate proteoglycan (HSPG) glycosaminoglycan chains and thereby to regulate interactions wit...

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Bibliographic Details
Main Authors: Megumi Morimoto-Tomita, Kenji Uchimura, Annette Bistrup, David H. Lum, Mikala Egeblad, Nancy Boudreau, Zena Werb, Steven D. Rosen
Format: Article
Language:English
Published: Elsevier 2005-11-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
extracellular endosulfatase
Sulf-2
breast cancer
angiogenesis
heparan sulfate
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800351

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