Medical and pharmacokinetic effects of nanopolyphenols: A systematic review of clinical trials
Abstract A significant percentage of the population has been turning to herbal remedies either as a sole treatment option or in combination with other drugs. Efforts to increase the production of therapeutic remedies from these scaffolds have therefore amplified. A fundamental aim when developing ne...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-06-01
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| Series: | Food Frontiers |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/fft2.72 |
| _version_ | 1818740780134563840 |
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| author | Theresa F. Rambaran Anna Nordström |
| author_facet | Theresa F. Rambaran Anna Nordström |
| author_sort | Theresa F. Rambaran |
| collection | DOAJ |
| description | Abstract A significant percentage of the population has been turning to herbal remedies either as a sole treatment option or in combination with other drugs. Efforts to increase the production of therapeutic remedies from these scaffolds have therefore amplified. A fundamental aim when developing new drugs is to develop drugs that have virtually no or less adverse effects than those currently available while being efficacious. Several approaches have been undertaken to use nanotechnology to develop nanoencapsulated polyphenols for use in therapeutics in an attempt to improve their physicochemical properties, bioavailability, and efficacy. This review covers the types of nanopolyphenols that have been evaluated in clinical trials against various medical conditions and their outcomes. Medical conditions covered include cardiometabolic diseases, inflammatory diseases, and cancer and in almost all instances the nanoencapsulated polyphenol produced a positive outcome. Similar outcomes were also reported for pharmacokinetic analyses. The review protocol was registered in the PROSPERO International Prospective Register of Systematic Reviews as CRD42020172642. |
| first_indexed | 2024-12-18T01:46:10Z |
| format | Article |
| id | doaj.art-4cd873384baf4cea89b24270ed1e59a7 |
| institution | Directory Open Access Journal |
| issn | 2643-8429 |
| language | English |
| last_indexed | 2024-12-18T01:46:10Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Frontiers |
| spelling | doaj.art-4cd873384baf4cea89b24270ed1e59a72022-12-21T21:25:11ZengWileyFood Frontiers2643-84292021-06-012214015210.1002/fft2.72Medical and pharmacokinetic effects of nanopolyphenols: A systematic review of clinical trialsTheresa F. Rambaran0Anna Nordström1Department of Public Health and Clinical Medicine, Section of Sustainable Health Umeå University Umeå SwedenDepartment of Public Health and Clinical Medicine, Section of Sustainable Health Umeå University Umeå SwedenAbstract A significant percentage of the population has been turning to herbal remedies either as a sole treatment option or in combination with other drugs. Efforts to increase the production of therapeutic remedies from these scaffolds have therefore amplified. A fundamental aim when developing new drugs is to develop drugs that have virtually no or less adverse effects than those currently available while being efficacious. Several approaches have been undertaken to use nanotechnology to develop nanoencapsulated polyphenols for use in therapeutics in an attempt to improve their physicochemical properties, bioavailability, and efficacy. This review covers the types of nanopolyphenols that have been evaluated in clinical trials against various medical conditions and their outcomes. Medical conditions covered include cardiometabolic diseases, inflammatory diseases, and cancer and in almost all instances the nanoencapsulated polyphenol produced a positive outcome. Similar outcomes were also reported for pharmacokinetic analyses. The review protocol was registered in the PROSPERO International Prospective Register of Systematic Reviews as CRD42020172642.https://doi.org/10.1002/fft2.72clinical trialnanoencapsulationnanomedicinenanopolyphenolspharmacokinetic effect |
| spellingShingle | Theresa F. Rambaran Anna Nordström Medical and pharmacokinetic effects of nanopolyphenols: A systematic review of clinical trials Food Frontiers clinical trial nanoencapsulation nanomedicine nanopolyphenols pharmacokinetic effect |
| title | Medical and pharmacokinetic effects of nanopolyphenols: A systematic review of clinical trials |
| title_full | Medical and pharmacokinetic effects of nanopolyphenols: A systematic review of clinical trials |
| title_fullStr | Medical and pharmacokinetic effects of nanopolyphenols: A systematic review of clinical trials |
| title_full_unstemmed | Medical and pharmacokinetic effects of nanopolyphenols: A systematic review of clinical trials |
| title_short | Medical and pharmacokinetic effects of nanopolyphenols: A systematic review of clinical trials |
| title_sort | medical and pharmacokinetic effects of nanopolyphenols a systematic review of clinical trials |
| topic | clinical trial nanoencapsulation nanomedicine nanopolyphenols pharmacokinetic effect |
| url | https://doi.org/10.1002/fft2.72 |
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