Roles of Non-Canonical Wnt Signalling Pathways in Bone Biology
The Wnt signalling pathway is one of the central signalling pathways in bone development, homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands, receptors and co-receptors, which ensure tight spatiotemporal regulation of Wnt signalling pathway activity and thus tigh...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/19/10840 |
| _version_ | 1797516195298017280 |
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| author | Jasna Lojk Janja Marc |
| author_facet | Jasna Lojk Janja Marc |
| author_sort | Jasna Lojk |
| collection | DOAJ |
| description | The Wnt signalling pathway is one of the central signalling pathways in bone development, homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands, receptors and co-receptors, which ensure tight spatiotemporal regulation of Wnt signalling pathway activity and thus tight regulation of bone tissue homeostasis. This enables maintenance of optimal mineral density, tissue healing and adaptation to changes in bone loading. While the role of the canonical/β-catenin Wnt signalling pathway in bone homeostasis is relatively well researched, Wnt ligands can also activate several non-canonical, β-catenin independent signalling pathways with important effects on bone tissue. In this review, we will provide a thorough overview of the current knowledge on different non-canonical Wnt signalling pathways involved in bone biology, focusing especially on the pathways that affect bone cell differentiation, maturation and function, processes involved in bone tissue structure regulation. We will describe the role of the two most known non-canonical pathways (Wnt/planar cell polarity pathways and Wnt/Ca<sup>2+</sup> pathway), as well as other signalling pathways with a strong role in bone biology that communicate with the Wnt signalling pathway through non-canonical Wnt signalling. Our goal is to bring additional attention to these still not well researched but important pathways in the regulation of bone biology in the hope of prompting additional research in the area of non-canonical Wnt signalling pathways. |
| first_indexed | 2024-03-10T06:58:45Z |
| format | Article |
| id | doaj.art-4cda84901d474c82b5f5eba634fd5a1e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:58:45Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4cda84901d474c82b5f5eba634fd5a1e2023-11-22T16:16:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122191084010.3390/ijms221910840Roles of Non-Canonical Wnt Signalling Pathways in Bone BiologyJasna Lojk0Janja Marc1Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, SloveniaDepartment of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, SloveniaThe Wnt signalling pathway is one of the central signalling pathways in bone development, homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands, receptors and co-receptors, which ensure tight spatiotemporal regulation of Wnt signalling pathway activity and thus tight regulation of bone tissue homeostasis. This enables maintenance of optimal mineral density, tissue healing and adaptation to changes in bone loading. While the role of the canonical/β-catenin Wnt signalling pathway in bone homeostasis is relatively well researched, Wnt ligands can also activate several non-canonical, β-catenin independent signalling pathways with important effects on bone tissue. In this review, we will provide a thorough overview of the current knowledge on different non-canonical Wnt signalling pathways involved in bone biology, focusing especially on the pathways that affect bone cell differentiation, maturation and function, processes involved in bone tissue structure regulation. We will describe the role of the two most known non-canonical pathways (Wnt/planar cell polarity pathways and Wnt/Ca<sup>2+</sup> pathway), as well as other signalling pathways with a strong role in bone biology that communicate with the Wnt signalling pathway through non-canonical Wnt signalling. Our goal is to bring additional attention to these still not well researched but important pathways in the regulation of bone biology in the hope of prompting additional research in the area of non-canonical Wnt signalling pathways.https://www.mdpi.com/1422-0067/22/19/10840non-canonical Wnt signalling pathwaybone mineral densitysignalling crosstalkosteogenesis |
| spellingShingle | Jasna Lojk Janja Marc Roles of Non-Canonical Wnt Signalling Pathways in Bone Biology International Journal of Molecular Sciences non-canonical Wnt signalling pathway bone mineral density signalling crosstalk osteogenesis |
| title | Roles of Non-Canonical Wnt Signalling Pathways in Bone Biology |
| title_full | Roles of Non-Canonical Wnt Signalling Pathways in Bone Biology |
| title_fullStr | Roles of Non-Canonical Wnt Signalling Pathways in Bone Biology |
| title_full_unstemmed | Roles of Non-Canonical Wnt Signalling Pathways in Bone Biology |
| title_short | Roles of Non-Canonical Wnt Signalling Pathways in Bone Biology |
| title_sort | roles of non canonical wnt signalling pathways in bone biology |
| topic | non-canonical Wnt signalling pathway bone mineral density signalling crosstalk osteogenesis |
| url | https://www.mdpi.com/1422-0067/22/19/10840 |
| work_keys_str_mv | AT jasnalojk rolesofnoncanonicalwntsignallingpathwaysinbonebiology AT janjamarc rolesofnoncanonicalwntsignallingpathwaysinbonebiology |