RELATION OF PLGF IN THE FIRST TRIMESTER TO FETAL SGA OR IUGR
PlGF determination today is of particular clinical importance in determining fetal-placental development. Placental growth factor PlGF is a human, genetically encoded protein. Objectives. Evaluation of the impact of PlGF in the first trimester, with the fetal SGA / IUGR. Material and method. The s...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2019-12-01
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| Series: | Romanian Medical Journal |
| Subjects: | |
| Online Access: | https://revistemedicale.amaltea.ro/Romanian_MEDICAL_Journal/Revista_MEDICALA_ROMANA-2019-Nr.4/RMJ_2019_4_Art-17.pdf |
| Summary: | PlGF determination today is of particular clinical importance in determining fetal-placental development. Placental growth factor PlGF is a human, genetically encoded protein.
Objectives. Evaluation of the impact of PlGF in the first trimester, with the fetal SGA / IUGR.
Material and method. The study is a prospective study conducted at the Special Gynecology Hospital "Mother
Teresa", Skopje, and the Clinical-Biochemical Laboratory, Institute of Immunology at the University Clinical Center
Skopje R, North Macedonia, from February 2019 - September 2010. 698 pregnant women were included in the study.
Outcomes. Out of all controlled patients in the period February 2019-June 2010, a total of 698 pregnant women were studied. increase in PlGF values, in 1 or 25 (25%) cases with SGA we have increased values of PlGF. PlGF
level > 40 pg/ml cut-off resulted in 337 or (48.28%) cases, and in 361 or (51.71)% cases have an increase in PlGF
< cut-off 40 pg/ml. Newborns with SGA / IUGR resulted in 4 or (0.57%) newborns, according to gestation evaluation
criteria.
Results. In our study PlGF resulted in: sensitivity 75%, specificity 50%, PPV 75%, NPV 50%, P = 0.25 and
R = 0.5.
Discussions. Assessment of placental development during pregnancy is one of the most important predictors of
fetal development and pre-eclampsia. In modern acupuncture protocols, new diagnostic methods are of particular
importance.
Conclusions. PlGF methods have their own difficulties due to the high cost of PlGF reagents, Opportunities for
further study are opened, because a new database has been formed in this area of obstetrics from clinically
validated and diagnosed patients. Ohet A computerized database of these problems is formed. |
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| ISSN: | 1220-5478 2069-606X |