RELATION OF PLGF IN THE FIRST TRIMESTER TO FETAL SGA OR IUGR
PlGF determination today is of particular clinical importance in determining fetal-placental development. Placental growth factor PlGF is a human, genetically encoded protein. Objectives. Evaluation of the impact of PlGF in the first trimester, with the fetal SGA / IUGR. Material and method. The s...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2019-12-01
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| Series: | Romanian Medical Journal |
| Subjects: | |
| Online Access: | https://revistemedicale.amaltea.ro/Romanian_MEDICAL_Journal/Revista_MEDICALA_ROMANA-2019-Nr.4/RMJ_2019_4_Art-17.pdf |
| _version_ | 1797333673099395072 |
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| author | Ismaili Bashkim |
| author_facet | Ismaili Bashkim |
| author_sort | Ismaili Bashkim |
| collection | DOAJ |
| description | PlGF determination today is of particular clinical importance in determining fetal-placental development. Placental growth factor PlGF is a human, genetically encoded protein.
Objectives. Evaluation of the impact of PlGF in the first trimester, with the fetal SGA / IUGR.
Material and method. The study is a prospective study conducted at the Special Gynecology Hospital "Mother
Teresa", Skopje, and the Clinical-Biochemical Laboratory, Institute of Immunology at the University Clinical Center
Skopje R, North Macedonia, from February 2019 - September 2010. 698 pregnant women were included in the study.
Outcomes. Out of all controlled patients in the period February 2019-June 2010, a total of 698 pregnant women were studied. increase in PlGF values, in 1 or 25 (25%) cases with SGA we have increased values of PlGF. PlGF
level > 40 pg/ml cut-off resulted in 337 or (48.28%) cases, and in 361 or (51.71)% cases have an increase in PlGF
< cut-off 40 pg/ml. Newborns with SGA / IUGR resulted in 4 or (0.57%) newborns, according to gestation evaluation
criteria.
Results. In our study PlGF resulted in: sensitivity 75%, specificity 50%, PPV 75%, NPV 50%, P = 0.25 and
R = 0.5.
Discussions. Assessment of placental development during pregnancy is one of the most important predictors of
fetal development and pre-eclampsia. In modern acupuncture protocols, new diagnostic methods are of particular
importance.
Conclusions. PlGF methods have their own difficulties due to the high cost of PlGF reagents, Opportunities for
further study are opened, because a new database has been formed in this area of obstetrics from clinically
validated and diagnosed patients. Ohet A computerized database of these problems is formed. |
| first_indexed | 2024-03-08T08:08:21Z |
| format | Article |
| id | doaj.art-4cdbb9c13a724073b9ee933440369677 |
| institution | Directory Open Access Journal |
| issn | 1220-5478 2069-606X |
| language | English |
| last_indexed | 2024-03-08T08:08:21Z |
| publishDate | 2019-12-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Medical Journal |
| spelling | doaj.art-4cdbb9c13a724073b9ee9334403696772024-02-02T10:01:04ZengAmaltea Medical Publishing HouseRomanian Medical Journal1220-54782069-606X2019-12-0166438939210.37897/RMJ.2019.4.17RELATION OF PLGF IN THE FIRST TRIMESTER TO FETAL SGA OR IUGRIsmaili Bashkim0IPH Special Hospital for Obstetry-Gyneacology “Mother Teresa” Chair-Skopje, Republic of North MacedoniaPlGF determination today is of particular clinical importance in determining fetal-placental development. Placental growth factor PlGF is a human, genetically encoded protein. Objectives. Evaluation of the impact of PlGF in the first trimester, with the fetal SGA / IUGR. Material and method. The study is a prospective study conducted at the Special Gynecology Hospital "Mother Teresa", Skopje, and the Clinical-Biochemical Laboratory, Institute of Immunology at the University Clinical Center Skopje R, North Macedonia, from February 2019 - September 2010. 698 pregnant women were included in the study. Outcomes. Out of all controlled patients in the period February 2019-June 2010, a total of 698 pregnant women were studied. increase in PlGF values, in 1 or 25 (25%) cases with SGA we have increased values of PlGF. PlGF level > 40 pg/ml cut-off resulted in 337 or (48.28%) cases, and in 361 or (51.71)% cases have an increase in PlGF < cut-off 40 pg/ml. Newborns with SGA / IUGR resulted in 4 or (0.57%) newborns, according to gestation evaluation criteria. Results. In our study PlGF resulted in: sensitivity 75%, specificity 50%, PPV 75%, NPV 50%, P = 0.25 and R = 0.5. Discussions. Assessment of placental development during pregnancy is one of the most important predictors of fetal development and pre-eclampsia. In modern acupuncture protocols, new diagnostic methods are of particular importance. Conclusions. PlGF methods have their own difficulties due to the high cost of PlGF reagents, Opportunities for further study are opened, because a new database has been formed in this area of obstetrics from clinically validated and diagnosed patients. Ohet A computerized database of these problems is formed.https://revistemedicale.amaltea.ro/Romanian_MEDICAL_Journal/Revista_MEDICALA_ROMANA-2019-Nr.4/RMJ_2019_4_Art-17.pdfplacental growth factorsga/iugr |
| spellingShingle | Ismaili Bashkim RELATION OF PLGF IN THE FIRST TRIMESTER TO FETAL SGA OR IUGR Romanian Medical Journal placental growth factor sga/iugr |
| title | RELATION OF PLGF IN THE FIRST TRIMESTER TO FETAL SGA OR IUGR |
| title_full | RELATION OF PLGF IN THE FIRST TRIMESTER TO FETAL SGA OR IUGR |
| title_fullStr | RELATION OF PLGF IN THE FIRST TRIMESTER TO FETAL SGA OR IUGR |
| title_full_unstemmed | RELATION OF PLGF IN THE FIRST TRIMESTER TO FETAL SGA OR IUGR |
| title_short | RELATION OF PLGF IN THE FIRST TRIMESTER TO FETAL SGA OR IUGR |
| title_sort | relation of plgf in the first trimester to fetal sga or iugr |
| topic | placental growth factor sga/iugr |
| url | https://revistemedicale.amaltea.ro/Romanian_MEDICAL_Journal/Revista_MEDICALA_ROMANA-2019-Nr.4/RMJ_2019_4_Art-17.pdf |
| work_keys_str_mv | AT ismailibashkim relationofplgfinthefirsttrimestertofetalsgaoriugr |