miR-1 inhibits migration of gastric cancer cells
Gastric cancer is the fourth most common malignancy world-wide that bears a high mortality by invasiveness and metastases. To this end, we examined the role of miR-1 in mobility and migration of gastric cancer cells. miR-1 was down-regulated and Sorcin, which supports invasion, was highly expressed...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2020-01-01
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| Series: | Frontiers in Bioscience-Landmark |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBL/25/3/10.2741/4813 |
| _version_ | 1828824089021644800 |
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| author | Xiu-qing Lin Wei Wu Xin Chen Ren-pin Chen Fang Wu Zhou-feng Chen Er-jiong Huang Chao Chen |
| author_facet | Xiu-qing Lin Wei Wu Xin Chen Ren-pin Chen Fang Wu Zhou-feng Chen Er-jiong Huang Chao Chen |
| author_sort | Xiu-qing Lin |
| collection | DOAJ |
| description | Gastric cancer is the fourth most common malignancy world-wide that bears a high mortality by invasiveness and metastases. To this end, we examined the role of miR-1 in mobility and migration of gastric cancer cells. miR-1 was down-regulated and Sorcin, which supports invasion, was highly expressed in gastric cancer cell lines as compared to the control. The overexpression of miR-1 significantly inhibited the mobility and migration of gastric cancer cells, while, its knockdown exerted an oppoiste effect. In addition, while overexpression of miR-1 suppressed the expression of Sorcin, the siRNA knockdown of Sorcin significantly counteracted the effect of miR-1 inhibitor on cell invasion and migration of gastric cancer cells. A miR-1 mimic decreased while its inhibitor increased the MMP-7 and VEGF required for invasion. Taken together, the findings support the view that miR-1 controls the mobility and migration of gastric cancer cells and might be a therapeutic target for blocking gastric cancer invasion. |
| first_indexed | 2024-12-12T13:50:06Z |
| format | Article |
| id | doaj.art-4cdd9005b8814ddbb276112eeb8e0e27 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-12-12T13:50:06Z |
| publishDate | 2020-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-4cdd9005b8814ddbb276112eeb8e0e272022-12-22T00:22:36ZengIMR PressFrontiers in Bioscience-Landmark2768-67012020-01-0125345246210.2741/4813FBS-25-452miR-1 inhibits migration of gastric cancer cellsXiu-qing Lin0Wei Wu1Xin Chen2Ren-pin Chen3Fang Wu4Zhou-feng Chen5Er-jiong Huang6Chao Chen7Department of Gastroenterology, The First affiliated hospital of Wenzhou medical University, 325000, ChinaDepartment of Gastroenterology, The First affiliated hospital of Wenzhou medical University, 325000, ChinaDepartment of Gastroenterology, The First affiliated hospital of Wenzhou medical University, 325000, ChinaDepartment of Gastroenterology, The First affiliated hospital of Wenzhou medical University, 325000, ChinaDepartment of Gastroenterology, The First affiliated hospital of Wenzhou medical University, 325000, ChinaDepartment of Gastroenterology, The First affiliated hospital of Wenzhou medical University, 325000, ChinaDepartment of Gastroenterology, The First affiliated hospital of Wenzhou medical University, 325000, ChinaDepartment of Gastroenterology, The First affiliated hospital of Wenzhou medical University, 325000, ChinaGastric cancer is the fourth most common malignancy world-wide that bears a high mortality by invasiveness and metastases. To this end, we examined the role of miR-1 in mobility and migration of gastric cancer cells. miR-1 was down-regulated and Sorcin, which supports invasion, was highly expressed in gastric cancer cell lines as compared to the control. The overexpression of miR-1 significantly inhibited the mobility and migration of gastric cancer cells, while, its knockdown exerted an oppoiste effect. In addition, while overexpression of miR-1 suppressed the expression of Sorcin, the siRNA knockdown of Sorcin significantly counteracted the effect of miR-1 inhibitor on cell invasion and migration of gastric cancer cells. A miR-1 mimic decreased while its inhibitor increased the MMP-7 and VEGF required for invasion. Taken together, the findings support the view that miR-1 controls the mobility and migration of gastric cancer cells and might be a therapeutic target for blocking gastric cancer invasion.https://www.imrpress.com/journal/FBL/25/3/10.2741/4813mir-1epithelial-mesenchymal transitiongastric cancersorcin |
| spellingShingle | Xiu-qing Lin Wei Wu Xin Chen Ren-pin Chen Fang Wu Zhou-feng Chen Er-jiong Huang Chao Chen miR-1 inhibits migration of gastric cancer cells Frontiers in Bioscience-Landmark mir-1 epithelial-mesenchymal transition gastric cancer sorcin |
| title | miR-1 inhibits migration of gastric cancer cells |
| title_full | miR-1 inhibits migration of gastric cancer cells |
| title_fullStr | miR-1 inhibits migration of gastric cancer cells |
| title_full_unstemmed | miR-1 inhibits migration of gastric cancer cells |
| title_short | miR-1 inhibits migration of gastric cancer cells |
| title_sort | mir 1 inhibits migration of gastric cancer cells |
| topic | mir-1 epithelial-mesenchymal transition gastric cancer sorcin |
| url | https://www.imrpress.com/journal/FBL/25/3/10.2741/4813 |
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