A biomimetic piezoelectric scaffold with sustained Mg2+ release promotes neurogenic and angiogenic differentiation for enhanced bone regeneration
Natural bone is a composite tissue made of organic and inorganic components, showing piezoelectricity. Whitlockite (WH), which is a natural magnesium-containing calcium phosphate, has attracted great attention in bone formation recently due to its unique piezoelectric property after sintering treatm...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2023-07-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X22004686 |
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| author | Liangyu Wang Yanyun Pang Yujing Tang Xinyu Wang Daixing Zhang Xu Zhang Yingjie Yu Xiaoping Yang Qing Cai |
| author_facet | Liangyu Wang Yanyun Pang Yujing Tang Xinyu Wang Daixing Zhang Xu Zhang Yingjie Yu Xiaoping Yang Qing Cai |
| author_sort | Liangyu Wang |
| collection | DOAJ |
| description | Natural bone is a composite tissue made of organic and inorganic components, showing piezoelectricity. Whitlockite (WH), which is a natural magnesium-containing calcium phosphate, has attracted great attention in bone formation recently due to its unique piezoelectric property after sintering treatment and sustained release of magnesium ion (Mg2+). Herein, a composite scaffold (denoted as PWH scaffold) composed of piezoelectric WH (PWH) and poly(ε-caprolactone) (PCL) was 3D printed to meet the physiological demands for the regeneration of neuro-vascularized bone tissue, namely, providing endogenous electric field at the defect site. The sustained release of Mg2+ from the PWH scaffold, displaying multiple biological activities, and thus exhibits a strong synergistic effect with the piezoelectricity on inhibiting osteoclast activation, promoting the neurogenic, angiogenic, and osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs) in vitro. In a rat calvarial defect model, this PWH scaffold is remarkably conducive to efficient neo-bone formation with rich neurogenic and angiogenic expressions. Overall, this study presents the first example of biomimetic piezoelectric scaffold with sustained Mg2+ release for promoting the regeneration of neuro-vascularized bone tissue in vivo, which offers new insights for regenerative medicine. |
| first_indexed | 2024-04-09T21:56:16Z |
| format | Article |
| id | doaj.art-4cded73fe5964a369fea9cbcaf4051ae |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-09T21:56:16Z |
| publishDate | 2023-07-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-4cded73fe5964a369fea9cbcaf4051ae2023-03-24T04:23:04ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-07-0125399414A biomimetic piezoelectric scaffold with sustained Mg2+ release promotes neurogenic and angiogenic differentiation for enhanced bone regenerationLiangyu Wang0Yanyun Pang1Yujing Tang2Xinyu Wang3Daixing Zhang4Xu Zhang5Yingjie Yu6Xiaoping Yang7Qing Cai8State Key Laboratory of Organic-Inorganic Composites; Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, ChinaSchool and Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, ChinaSINOPEC (Beijing) Research Institute of Chemical Industry Co., Ltd., Beijing, 100013, ChinaState Key Laboratory of Organic-Inorganic Composites; Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, ChinaState Key Laboratory of Organic-Inorganic Composites; Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, ChinaSchool and Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, ChinaState Key Laboratory of Organic-Inorganic Composites; Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China; Corresponding author.State Key Laboratory of Organic-Inorganic Composites; Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China; Foshan (Southern China) Institute for New Materials, Foshan, 528200, Guangdong, ChinaState Key Laboratory of Organic-Inorganic Composites; Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China; Corresponding author.Natural bone is a composite tissue made of organic and inorganic components, showing piezoelectricity. Whitlockite (WH), which is a natural magnesium-containing calcium phosphate, has attracted great attention in bone formation recently due to its unique piezoelectric property after sintering treatment and sustained release of magnesium ion (Mg2+). Herein, a composite scaffold (denoted as PWH scaffold) composed of piezoelectric WH (PWH) and poly(ε-caprolactone) (PCL) was 3D printed to meet the physiological demands for the regeneration of neuro-vascularized bone tissue, namely, providing endogenous electric field at the defect site. The sustained release of Mg2+ from the PWH scaffold, displaying multiple biological activities, and thus exhibits a strong synergistic effect with the piezoelectricity on inhibiting osteoclast activation, promoting the neurogenic, angiogenic, and osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs) in vitro. In a rat calvarial defect model, this PWH scaffold is remarkably conducive to efficient neo-bone formation with rich neurogenic and angiogenic expressions. Overall, this study presents the first example of biomimetic piezoelectric scaffold with sustained Mg2+ release for promoting the regeneration of neuro-vascularized bone tissue in vivo, which offers new insights for regenerative medicine.http://www.sciencedirect.com/science/article/pii/S2452199X22004686Bone regenerationPiezoelectricityNeurogenicAngiogenicOsteogenic |
| spellingShingle | Liangyu Wang Yanyun Pang Yujing Tang Xinyu Wang Daixing Zhang Xu Zhang Yingjie Yu Xiaoping Yang Qing Cai A biomimetic piezoelectric scaffold with sustained Mg2+ release promotes neurogenic and angiogenic differentiation for enhanced bone regeneration Bioactive Materials Bone regeneration Piezoelectricity Neurogenic Angiogenic Osteogenic |
| title | A biomimetic piezoelectric scaffold with sustained Mg2+ release promotes neurogenic and angiogenic differentiation for enhanced bone regeneration |
| title_full | A biomimetic piezoelectric scaffold with sustained Mg2+ release promotes neurogenic and angiogenic differentiation for enhanced bone regeneration |
| title_fullStr | A biomimetic piezoelectric scaffold with sustained Mg2+ release promotes neurogenic and angiogenic differentiation for enhanced bone regeneration |
| title_full_unstemmed | A biomimetic piezoelectric scaffold with sustained Mg2+ release promotes neurogenic and angiogenic differentiation for enhanced bone regeneration |
| title_short | A biomimetic piezoelectric scaffold with sustained Mg2+ release promotes neurogenic and angiogenic differentiation for enhanced bone regeneration |
| title_sort | biomimetic piezoelectric scaffold with sustained mg2 release promotes neurogenic and angiogenic differentiation for enhanced bone regeneration |
| topic | Bone regeneration Piezoelectricity Neurogenic Angiogenic Osteogenic |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X22004686 |
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