Development of Second Generation Activity-Based Chemical Probes for Sirtuins

Development of Second Generation Activity-Based Chemical Probes for Sirtuins

NAD<sup>+</sup> (nicotinamide adenine dinucleotide)-dependent protein deacylases, namely, the sirtuins, are important cell adaptor proteins that alter cell physiology in response to low calorie conditions. They are thought to mediate the beneficial effects of calorie restriction to exten...

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Bibliographic Details
Main Authors: Alyson M. Curry, Elizabeth Barton, Wenjia Kang, Daniel V. Mongeluzi, Yana Cen
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
sirtuin
activity-based
chemical probes
Online Access:https://www.mdpi.com/1420-3049/26/1/11

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