Expression levels of a kinesin-13 microtubule depolymerase modulates the effectiveness of anti-microtubule agents.

Expression levels of a kinesin-13 microtubule depolymerase modulates the effectiveness of anti-microtubule agents.

Chemotherapeutic drugs often target the microtubule cytoskeleton as a means to disrupt cancer cell mitosis and proliferation. Anti-microtubule drugs inhibit microtubule dynamics, thereby triggering apoptosis when dividing cells activate the mitotic checkpoint. Microtubule dynamics are regulated by m...

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Bibliographic Details
Main Authors:	Gregory V Schimizzi, Joshua D Currie, Stephen L Rogers
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2010-06-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2894863?pdf=render

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