Effect of intravenous dexmedetomidine on haemodynamic responses to laryngoscopy, tracheal intubation and anaesthetic and analgesic requirements: a randomized double-blind clinical efficacy study
Background: Dexmedetomidine is an alpha 2-adrenergic receptor agonist that provides sedation, anxiolysis, hypnosis, analgesia, and sympatholysis. The present study is aimed to assess the efficacy of dexmedetomidine in attenuating sympathoadrenal response to laryngoscopy and tracheal intubation and t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-10-01
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| Series: | Journal of Clinical and Scientific Research |
| Subjects: | |
| Online Access: | http://svimstpt.ap.nic.in/jcsr/oct-dec16_files/1oa.15.033.pdf |
| _version_ | 1818490480423337984 |
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| author | Madhusudan M Lavakumar A Rao MH Samantaray A Charupalli K |
| author_facet | Madhusudan M Lavakumar A Rao MH Samantaray A Charupalli K |
| author_sort | Madhusudan M |
| collection | DOAJ |
| description | Background: Dexmedetomidine is an alpha 2-adrenergic receptor agonist that provides sedation, anxiolysis, hypnosis, analgesia, and sympatholysis. The present study is aimed to assess the efficacy of dexmedetomidine in attenuating sympathoadrenal response to laryngoscopy and tracheal intubation and to analyse its effect on intraoperative anaesthetic and analgesic requirements.
Methods: Sixty patients were randomized to receive either dexmedetomidine 1µg/kg (Group D) or 10 mL of 0.9% saline (Group S) over 10 minutes before induction of anaesthesia and after standard induction procedure the same study drug infusions were continued. Blood pressure, heart rate (HR) and Ramsay sedation score (RSS) were monitored at fixed time interval after study drug infusion and anaesthesia induction.
Results: After study drug administration the changes in HR and blood pressure was statistically significant between the groups (p = <0.001) at all-time intervals during study period. There was 50% reduction in thiopentone requirements in Group D in comparison to Group S (p<0.001). The intraoperative additional dose of morphine requirement was less in Group D in comparison to Group S to maintain the steady haemodynamics (p<0.001). Statistically significant difference was noticed in Group D regarding RSS at 5 min and 10 min after study drug infusion (p=0.025 and p=0.001
respectively) and again at 30 min after extubation (p= 0.002) when compared with Group S.
Conclusions: Our observations suggest that dexmedetomidine was effective in attenuating the heart rate and blood pressure rise during laryngoscopy and intubation, and decrease the thiopentone and morphine requirements intraoperatively. |
| first_indexed | 2024-12-10T17:17:36Z |
| format | Article |
| id | doaj.art-4ce0bae4257841f8aba2aa8bb111d9e3 |
| institution | Directory Open Access Journal |
| issn | 2277-5706 2277-8357 |
| language | English |
| last_indexed | 2024-12-10T17:17:36Z |
| publishDate | 2016-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical and Scientific Research |
| spelling | doaj.art-4ce0bae4257841f8aba2aa8bb111d9e32022-12-22T01:40:05ZengWolters Kluwer Medknow PublicationsJournal of Clinical and Scientific Research2277-57062277-83572016-10-015420521310.15380/2277-5706.JCSR.15.033Effect of intravenous dexmedetomidine on haemodynamic responses to laryngoscopy, tracheal intubation and anaesthetic and analgesic requirements: a randomized double-blind clinical efficacy studyMadhusudan M0Lavakumar A1Rao MH2Samantaray A3Charupalli K4Sri Venkateswara Institute of Medical Sciences, TirupatiSri Venkateswara Institute of Medical Sciences, TirupatiSri Venkateswara Institute of Medical Sciences, TirupatiSri Venkateswara Institute of Medical Sciences, TirupatiSri Venkateswara Medical College, TirupatiBackground: Dexmedetomidine is an alpha 2-adrenergic receptor agonist that provides sedation, anxiolysis, hypnosis, analgesia, and sympatholysis. The present study is aimed to assess the efficacy of dexmedetomidine in attenuating sympathoadrenal response to laryngoscopy and tracheal intubation and to analyse its effect on intraoperative anaesthetic and analgesic requirements. Methods: Sixty patients were randomized to receive either dexmedetomidine 1µg/kg (Group D) or 10 mL of 0.9% saline (Group S) over 10 minutes before induction of anaesthesia and after standard induction procedure the same study drug infusions were continued. Blood pressure, heart rate (HR) and Ramsay sedation score (RSS) were monitored at fixed time interval after study drug infusion and anaesthesia induction. Results: After study drug administration the changes in HR and blood pressure was statistically significant between the groups (p = <0.001) at all-time intervals during study period. There was 50% reduction in thiopentone requirements in Group D in comparison to Group S (p<0.001). The intraoperative additional dose of morphine requirement was less in Group D in comparison to Group S to maintain the steady haemodynamics (p<0.001). Statistically significant difference was noticed in Group D regarding RSS at 5 min and 10 min after study drug infusion (p=0.025 and p=0.001 respectively) and again at 30 min after extubation (p= 0.002) when compared with Group S. Conclusions: Our observations suggest that dexmedetomidine was effective in attenuating the heart rate and blood pressure rise during laryngoscopy and intubation, and decrease the thiopentone and morphine requirements intraoperatively.http://svimstpt.ap.nic.in/jcsr/oct-dec16_files/1oa.15.033.pdfDexmedetomidineLaryngoscopyThiopentoneMorphinehaemodynamics |
| spellingShingle | Madhusudan M Lavakumar A Rao MH Samantaray A Charupalli K Effect of intravenous dexmedetomidine on haemodynamic responses to laryngoscopy, tracheal intubation and anaesthetic and analgesic requirements: a randomized double-blind clinical efficacy study Journal of Clinical and Scientific Research Dexmedetomidine Laryngoscopy Thiopentone Morphine haemodynamics |
| title | Effect of intravenous dexmedetomidine on haemodynamic responses to laryngoscopy, tracheal intubation and anaesthetic and analgesic requirements: a randomized double-blind clinical efficacy study |
| title_full | Effect of intravenous dexmedetomidine on haemodynamic responses to laryngoscopy, tracheal intubation and anaesthetic and analgesic requirements: a randomized double-blind clinical efficacy study |
| title_fullStr | Effect of intravenous dexmedetomidine on haemodynamic responses to laryngoscopy, tracheal intubation and anaesthetic and analgesic requirements: a randomized double-blind clinical efficacy study |
| title_full_unstemmed | Effect of intravenous dexmedetomidine on haemodynamic responses to laryngoscopy, tracheal intubation and anaesthetic and analgesic requirements: a randomized double-blind clinical efficacy study |
| title_short | Effect of intravenous dexmedetomidine on haemodynamic responses to laryngoscopy, tracheal intubation and anaesthetic and analgesic requirements: a randomized double-blind clinical efficacy study |
| title_sort | effect of intravenous dexmedetomidine on haemodynamic responses to laryngoscopy tracheal intubation and anaesthetic and analgesic requirements a randomized double blind clinical efficacy study |
| topic | Dexmedetomidine Laryngoscopy Thiopentone Morphine haemodynamics |
| url | http://svimstpt.ap.nic.in/jcsr/oct-dec16_files/1oa.15.033.pdf |
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