Molecular Approaches for Diagnosis, Therapy and Prevention of Cow’s Milk Allergy
Cow’s milk is one of the most important and basic nutrients introduced early in life in our diet but can induce IgE-associated allergy. IgE-associated allergy to cow’s milk can cause severe allergic manifestations in the gut, skin and even in the respiratory tract and may lead to...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-06-01
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| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/11/7/1492 |
| _version_ | 1811270910413373440 |
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| author | Birgit Linhart Raphaela Freidl Olga Elisyutina Musa Khaitov Alexander Karaulov Rudolf Valenta |
| author_facet | Birgit Linhart Raphaela Freidl Olga Elisyutina Musa Khaitov Alexander Karaulov Rudolf Valenta |
| author_sort | Birgit Linhart |
| collection | DOAJ |
| description | Cow’s milk is one of the most important and basic nutrients introduced early in life in our diet but can induce IgE-associated allergy. IgE-associated allergy to cow’s milk can cause severe allergic manifestations in the gut, skin and even in the respiratory tract and may lead to life-threatening anaphylactic shock due to the stability of certain cow’s milk allergens. Here, we provide an overview about the allergen molecules in cow’s milk and the advantages of the molecular diagnosis of IgE sensitization to cow’s milk by serology. In addition, we review current strategies for prevention and treatment of cow’s milk allergy and discuss how they could be improved in the future by innovative molecular approaches that are based on defined recombinant allergens, recombinant hypoallergenic allergen derivatives and synthetic peptides. |
| first_indexed | 2024-04-12T22:10:33Z |
| format | Article |
| id | doaj.art-4ce17e089e414c55bff63fabae4b3865 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-04-12T22:10:33Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-4ce17e089e414c55bff63fabae4b38652022-12-22T03:14:46ZengMDPI AGNutrients2072-66432019-06-01117149210.3390/nu11071492nu11071492Molecular Approaches for Diagnosis, Therapy and Prevention of Cow’s Milk AllergyBirgit Linhart0Raphaela Freidl1Olga Elisyutina2Musa Khaitov3Alexander Karaulov4Rudolf Valenta5Department of Pathophysiology and Allergy Research, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Pathophysiology and Allergy Research, Medical University of Vienna, 1090 Vienna, AustriaNRC Institute of Immunology FMBA of Russia, 115478 Moscow, RussiaNRC Institute of Immunology FMBA of Russia, 115478 Moscow, RussiaLaboratory of Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, 119435 Moscow, RussiaDepartment of Pathophysiology and Allergy Research, Medical University of Vienna, 1090 Vienna, AustriaCow’s milk is one of the most important and basic nutrients introduced early in life in our diet but can induce IgE-associated allergy. IgE-associated allergy to cow’s milk can cause severe allergic manifestations in the gut, skin and even in the respiratory tract and may lead to life-threatening anaphylactic shock due to the stability of certain cow’s milk allergens. Here, we provide an overview about the allergen molecules in cow’s milk and the advantages of the molecular diagnosis of IgE sensitization to cow’s milk by serology. In addition, we review current strategies for prevention and treatment of cow’s milk allergy and discuss how they could be improved in the future by innovative molecular approaches that are based on defined recombinant allergens, recombinant hypoallergenic allergen derivatives and synthetic peptides.https://www.mdpi.com/2072-6643/11/7/1492cow’s milk allergycow’s milk allergensdiagnosis of cow’s milk allergymolecular diagnosistreatment of cow’s milk allergyprevention of cow’s milk allergy |
| spellingShingle | Birgit Linhart Raphaela Freidl Olga Elisyutina Musa Khaitov Alexander Karaulov Rudolf Valenta Molecular Approaches for Diagnosis, Therapy and Prevention of Cow’s Milk Allergy Nutrients cow’s milk allergy cow’s milk allergens diagnosis of cow’s milk allergy molecular diagnosis treatment of cow’s milk allergy prevention of cow’s milk allergy |
| title | Molecular Approaches for Diagnosis, Therapy and Prevention of Cow’s Milk Allergy |
| title_full | Molecular Approaches for Diagnosis, Therapy and Prevention of Cow’s Milk Allergy |
| title_fullStr | Molecular Approaches for Diagnosis, Therapy and Prevention of Cow’s Milk Allergy |
| title_full_unstemmed | Molecular Approaches for Diagnosis, Therapy and Prevention of Cow’s Milk Allergy |
| title_short | Molecular Approaches for Diagnosis, Therapy and Prevention of Cow’s Milk Allergy |
| title_sort | molecular approaches for diagnosis therapy and prevention of cow s milk allergy |
| topic | cow’s milk allergy cow’s milk allergens diagnosis of cow’s milk allergy molecular diagnosis treatment of cow’s milk allergy prevention of cow’s milk allergy |
| url | https://www.mdpi.com/2072-6643/11/7/1492 |
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