Metabolic profiling of serum and urine in preeclampsia and gestational diabetes in early pregnancy
PE and GDM are two major metabolic diseases affecting pregnancy. Individuals suffering from GDM are at an increased risk of developing PE in later gestational stages. Current study was done to evaluate first trimester serum and urine metabolome using nuclear magnetic resonance (NMR) spectroscopy to...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Medicine in Drug Discovery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590098622000240 |
| _version_ | 1811186612700184576 |
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| author | Nupur Rani Agarwal Garima Kachhawa Bolaji Fatai Oyeyemi Neel Sarovar Bhavesh |
| author_facet | Nupur Rani Agarwal Garima Kachhawa Bolaji Fatai Oyeyemi Neel Sarovar Bhavesh |
| author_sort | Nupur Rani Agarwal |
| collection | DOAJ |
| description | PE and GDM are two major metabolic diseases affecting pregnancy. Individuals suffering from GDM are at an increased risk of developing PE in later gestational stages. Current study was done to evaluate first trimester serum and urine metabolome using nuclear magnetic resonance (NMR) spectroscopy to identify metabolites and pathways differentially regulated in both diseases. Serum metabolomics analysis revealed deregulation in larger group of metabolites and pathways as compared to urine between PE/GDM and NT groups. Few metabolites showed altered expression in both aliments. Perturbed metabolites have association with energy metabolism, protein metabolism, insulin sensitivity, gut microbiome and maintenance of redox balance. Deregulation in these metabolic pathways contributes to the pathology of GDM/PE. Our study revealed that serum metabolomic profile of PE and GDM shows overlap in 1st trimester of gestation. It also explored the potential of NMR metabolomics in identification of common biomolecules that could be developed into a clinical tool for early detection of both PE /GDM.. |
| first_indexed | 2024-04-11T13:48:18Z |
| format | Article |
| id | doaj.art-4ce2370668794c2babbdc3f64fafb495 |
| institution | Directory Open Access Journal |
| issn | 2590-0986 |
| language | English |
| last_indexed | 2024-04-11T13:48:18Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medicine in Drug Discovery |
| spelling | doaj.art-4ce2370668794c2babbdc3f64fafb4952022-12-22T04:20:50ZengElsevierMedicine in Drug Discovery2590-09862022-12-0116100143Metabolic profiling of serum and urine in preeclampsia and gestational diabetes in early pregnancyNupur Rani Agarwal0Garima Kachhawa1Bolaji Fatai Oyeyemi2Neel Sarovar Bhavesh3Transcription Regulation Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi 110067, India; Corresponding authors at: Transcription Regulation Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, India.Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi 110029, IndiaTranscription Regulation Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi 110067, IndiaTranscription Regulation Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi 110067, India; Corresponding authors at: Transcription Regulation Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, India.PE and GDM are two major metabolic diseases affecting pregnancy. Individuals suffering from GDM are at an increased risk of developing PE in later gestational stages. Current study was done to evaluate first trimester serum and urine metabolome using nuclear magnetic resonance (NMR) spectroscopy to identify metabolites and pathways differentially regulated in both diseases. Serum metabolomics analysis revealed deregulation in larger group of metabolites and pathways as compared to urine between PE/GDM and NT groups. Few metabolites showed altered expression in both aliments. Perturbed metabolites have association with energy metabolism, protein metabolism, insulin sensitivity, gut microbiome and maintenance of redox balance. Deregulation in these metabolic pathways contributes to the pathology of GDM/PE. Our study revealed that serum metabolomic profile of PE and GDM shows overlap in 1st trimester of gestation. It also explored the potential of NMR metabolomics in identification of common biomolecules that could be developed into a clinical tool for early detection of both PE /GDM..http://www.sciencedirect.com/science/article/pii/S2590098622000240Gestational diabetesInsulin resistanceMetabolomicsOxidative stressPreeclampsia |
| spellingShingle | Nupur Rani Agarwal Garima Kachhawa Bolaji Fatai Oyeyemi Neel Sarovar Bhavesh Metabolic profiling of serum and urine in preeclampsia and gestational diabetes in early pregnancy Medicine in Drug Discovery Gestational diabetes Insulin resistance Metabolomics Oxidative stress Preeclampsia |
| title | Metabolic profiling of serum and urine in preeclampsia and gestational diabetes in early pregnancy |
| title_full | Metabolic profiling of serum and urine in preeclampsia and gestational diabetes in early pregnancy |
| title_fullStr | Metabolic profiling of serum and urine in preeclampsia and gestational diabetes in early pregnancy |
| title_full_unstemmed | Metabolic profiling of serum and urine in preeclampsia and gestational diabetes in early pregnancy |
| title_short | Metabolic profiling of serum and urine in preeclampsia and gestational diabetes in early pregnancy |
| title_sort | metabolic profiling of serum and urine in preeclampsia and gestational diabetes in early pregnancy |
| topic | Gestational diabetes Insulin resistance Metabolomics Oxidative stress Preeclampsia |
| url | http://www.sciencedirect.com/science/article/pii/S2590098622000240 |
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