Elevated serum interleukin-6 is predictive of coronary artery disease in intermediate risk overweight patients referred for coronary angiography
Abstract Background Interleukin-6 (IL-6) plays a central role in atherosclerosis and inflammation. It may improve risk prediction in patients at intermediate cardiovascular risk. Objective To analyze the impact of serum IL-6 in predicting early angiographic coronary artery disease in patients at int...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-09-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | http://link.springer.com/article/10.1186/s13098-017-0266-5 |
| _version_ | 1818191102085169152 |
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| author | Marco V. Wainstein Márcio Mossmann Gustavo N. Araujo Sandro C. Gonçalves Gabriela L. Gravina Marlei Sangalli Francine Veadrigo Roselene Matte Rejane Reich Fernanda G. Costa Michael Andrades Antônio Marcos V. da Silva Marcello C. Bertoluci |
| author_facet | Marco V. Wainstein Márcio Mossmann Gustavo N. Araujo Sandro C. Gonçalves Gabriela L. Gravina Marlei Sangalli Francine Veadrigo Roselene Matte Rejane Reich Fernanda G. Costa Michael Andrades Antônio Marcos V. da Silva Marcello C. Bertoluci |
| author_sort | Marco V. Wainstein |
| collection | DOAJ |
| description | Abstract Background Interleukin-6 (IL-6) plays a central role in atherosclerosis and inflammation. It may improve risk prediction in patients at intermediate cardiovascular risk. Objective To analyze the impact of serum IL-6 in predicting early angiographic coronary artery disease in patients at intermediate cardiovascular risk with chest pain. Methods In a cross-sectional study, patients referred for coronary angiography due to suspected coronary artery disease (CAD) were included. Coronary artery disease was defined as the presence of at least 30% stenosis in one or more coronary artery. Severity of CAD was classified by the anatomic burden score. Performance of serum IL-6 assay was compared with ACC/AHA atherosclerotic cardiovascular disease (ASCVD) risk score and hs-CRP through receiver operating characteristic (ROC) curves. Results We have included 48 patients with a mean 10-year ASCVD risk of 10.0 ± 6.8%. The prevalence of CAD was 72.9%. The presence of CAD was associated with higher mean levels of IL-6 (p = 0.025). Patients with CAD had significantly more overweight than subjects without CAD. In 27% of patients, IL-6 was >1.0 pg/mL and 100% of these patients had CAD, while only 64% in those with IL-6 <1.0 pg/mL, corresponding to a positive predictive value of 100% (p = 0.015). The area under the receiver operating characteristic (ROC) curve of IL-6, hs-CRP and ASCVD were respectively 0.72, 0.60 and 0.54. Intermediate risk patients with IL-6 >1.0 pg/mL were further reclassified into ASCVD high risk due to the presence of coronary lesions. Conclusion In intermediate risk patients referred for coronary angiography, a serum IL-6 level above 1 pg/mL is predictive of significant CAD. IL-6 determination may be useful to reclassify ASCVD intermediate risk patients into higher risk categories. |
| first_indexed | 2024-12-12T00:09:16Z |
| format | Article |
| id | doaj.art-4ce2928c29a54125a94056aa311358a0 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-12-12T00:09:16Z |
| publishDate | 2017-09-01 |
| publisher | BMC |
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| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-4ce2928c29a54125a94056aa311358a02022-12-22T00:45:02ZengBMCDiabetology & Metabolic Syndrome1758-59962017-09-01911710.1186/s13098-017-0266-5Elevated serum interleukin-6 is predictive of coronary artery disease in intermediate risk overweight patients referred for coronary angiographyMarco V. Wainstein0Márcio Mossmann1Gustavo N. Araujo2Sandro C. Gonçalves3Gabriela L. Gravina4Marlei Sangalli5Francine Veadrigo6Roselene Matte7Rejane Reich8Fernanda G. Costa9Michael Andrades10Antônio Marcos V. da Silva11Marcello C. Bertoluci12Programa de Pós-Graduação em Medicina: Cardiologia, Universidade Federal do Rio Grande do SulPrograma de Pós-Graduação em Medicina: Cardiologia, Universidade Federal do Rio Grande do SulPrograma de Pós-Graduação em Medicina: Cardiologia, Universidade Federal do Rio Grande do SulPrograma de Pós-Graduação em Medicina: Cardiologia, Universidade Federal do Rio Grande do SulFaculdade de Medicina da, Universidade Federal do Rio Grande do SulFaculdade de Medicina da, Universidade Federal do Rio Grande do SulFaculdade de Medicina da, Universidade Federal do Rio Grande do SulServiço de Cardiologia do, Hospital de Clínicas de Porto AlegreServiço de Cardiologia do, Hospital de Clínicas de Porto AlegreServiço de Cardiologia do, Hospital de Clínicas de Porto AlegreUnidade de Análises Moleculares e de Proteínas (UAMP), Hospital de Clinicas de Porto AlegreDepartamento de Fisioterapia e Reabilitação, Universidade Federal de Santa MariaServiço de Medicina Interna do, Hospital de Clínicas de Porto AlegreAbstract Background Interleukin-6 (IL-6) plays a central role in atherosclerosis and inflammation. It may improve risk prediction in patients at intermediate cardiovascular risk. Objective To analyze the impact of serum IL-6 in predicting early angiographic coronary artery disease in patients at intermediate cardiovascular risk with chest pain. Methods In a cross-sectional study, patients referred for coronary angiography due to suspected coronary artery disease (CAD) were included. Coronary artery disease was defined as the presence of at least 30% stenosis in one or more coronary artery. Severity of CAD was classified by the anatomic burden score. Performance of serum IL-6 assay was compared with ACC/AHA atherosclerotic cardiovascular disease (ASCVD) risk score and hs-CRP through receiver operating characteristic (ROC) curves. Results We have included 48 patients with a mean 10-year ASCVD risk of 10.0 ± 6.8%. The prevalence of CAD was 72.9%. The presence of CAD was associated with higher mean levels of IL-6 (p = 0.025). Patients with CAD had significantly more overweight than subjects without CAD. In 27% of patients, IL-6 was >1.0 pg/mL and 100% of these patients had CAD, while only 64% in those with IL-6 <1.0 pg/mL, corresponding to a positive predictive value of 100% (p = 0.015). The area under the receiver operating characteristic (ROC) curve of IL-6, hs-CRP and ASCVD were respectively 0.72, 0.60 and 0.54. Intermediate risk patients with IL-6 >1.0 pg/mL were further reclassified into ASCVD high risk due to the presence of coronary lesions. Conclusion In intermediate risk patients referred for coronary angiography, a serum IL-6 level above 1 pg/mL is predictive of significant CAD. IL-6 determination may be useful to reclassify ASCVD intermediate risk patients into higher risk categories.http://link.springer.com/article/10.1186/s13098-017-0266-5Interleukin-6Risk factorsRisk scoresCoronary angiographyInflammationCoronary artery disease |
| spellingShingle | Marco V. Wainstein Márcio Mossmann Gustavo N. Araujo Sandro C. Gonçalves Gabriela L. Gravina Marlei Sangalli Francine Veadrigo Roselene Matte Rejane Reich Fernanda G. Costa Michael Andrades Antônio Marcos V. da Silva Marcello C. Bertoluci Elevated serum interleukin-6 is predictive of coronary artery disease in intermediate risk overweight patients referred for coronary angiography Diabetology & Metabolic Syndrome Interleukin-6 Risk factors Risk scores Coronary angiography Inflammation Coronary artery disease |
| title | Elevated serum interleukin-6 is predictive of coronary artery disease in intermediate risk overweight patients referred for coronary angiography |
| title_full | Elevated serum interleukin-6 is predictive of coronary artery disease in intermediate risk overweight patients referred for coronary angiography |
| title_fullStr | Elevated serum interleukin-6 is predictive of coronary artery disease in intermediate risk overweight patients referred for coronary angiography |
| title_full_unstemmed | Elevated serum interleukin-6 is predictive of coronary artery disease in intermediate risk overweight patients referred for coronary angiography |
| title_short | Elevated serum interleukin-6 is predictive of coronary artery disease in intermediate risk overweight patients referred for coronary angiography |
| title_sort | elevated serum interleukin 6 is predictive of coronary artery disease in intermediate risk overweight patients referred for coronary angiography |
| topic | Interleukin-6 Risk factors Risk scores Coronary angiography Inflammation Coronary artery disease |
| url | http://link.springer.com/article/10.1186/s13098-017-0266-5 |
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