Phytocannabinoid-rich galenic preparations for topical administration: extraction and stability testing
Although medical cannabis was legalized in Czechia in 2013 and its use in topical treatments of skin disorders is now allowed, galenic formulations prepared from medical cannabis have not been widely implemented in the Czech healthcare system. One of the main reasons is the lack of a straightforward...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1230728/full |
| _version_ | 1797767114308714496 |
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| author | Dominika Kaczorová Dominika Kaczorová Dominika Kaczorová Jaroslav Peč Tibor Béres Nikola Štefelová Sanja Ćavar Zeljković Sanja Ćavar Zeljković Václav Trojan Anežka Kosmáková Janatová Pavel Klouček Petr Tarkowski Petr Tarkowski |
| author_facet | Dominika Kaczorová Dominika Kaczorová Dominika Kaczorová Jaroslav Peč Tibor Béres Nikola Štefelová Sanja Ćavar Zeljković Sanja Ćavar Zeljković Václav Trojan Anežka Kosmáková Janatová Pavel Klouček Petr Tarkowski Petr Tarkowski |
| author_sort | Dominika Kaczorová |
| collection | DOAJ |
| description | Although medical cannabis was legalized in Czechia in 2013 and its use in topical treatments of skin disorders is now allowed, galenic formulations prepared from medical cannabis have not been widely implemented in the Czech healthcare system. One of the main reasons is the lack of a straightforward standardized protocol for their preparation. Cannabinoids, e.g., cannabidiol (CBD) and tetrahydrocannabinol (THC), have been shown to have therapeutic effects on various skin conditions, such as atopic dermatitis, psoriasis, scleroderma, acne and skin pigmentation. Recognizing the potential of dermatological treatment with medical cannabis, the present study aimed to evaluate the extraction capacity of various pharmaceutical bases for cannabinoids and the stability of prepared galenic formulations for dermatological applications with respect to cannabinoid content. The results showed that the stability of cannabinoids in formulations depended on the bases’ physical and chemical properties. The highest THC decomposition was observed in cream bases and Vaseline, with estimated percentage loss of total content of up to 5.4% and 5.6% per week, respectively. In contrast, CBD was more stable than THC. Overall, the tested bases were comparably effective in extracting cannabinoids from plant material. However, olive oil and Synderman bases exhibited the highest cannabinoid extraction efficiencies (approximately 70%) and the best storage stabilities in terms of the content of monitored compounds. The proposed preparation protocol is fast and easily implementable in pharmacies and medical facilities. |
| first_indexed | 2024-03-12T20:35:06Z |
| format | Article |
| id | doaj.art-4ce4b5a48b29493b971c63fb101aa0b0 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-12T20:35:06Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-4ce4b5a48b29493b971c63fb101aa0b02023-08-01T13:34:33ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-08-011410.3389/fphar.2023.12307281230728Phytocannabinoid-rich galenic preparations for topical administration: extraction and stability testingDominika Kaczorová0Dominika Kaczorová1Dominika Kaczorová2Jaroslav Peč3Tibor Béres4Nikola Štefelová5Sanja Ćavar Zeljković6Sanja Ćavar Zeljković7Václav Trojan8Anežka Kosmáková Janatová9Pavel Klouček10Petr Tarkowski11Petr Tarkowski12Czech Advanced Technology and Research Institute, Palacký University, Olomouc, CzechiaDepartment of Genetic Resources for Vegetables, Medicinal and Special Plants, Centre of the Region Haná for Biotechnological and Agricultural Research, Crop Research Institute, Olomouc, CzechiaDepartment of Biochemistry, Faculty of Science, Palacký University, Olomouc, CzechiaPharm & Herb s. r. o, Prostějov, CzechiaCzech Advanced Technology and Research Institute, Palacký University, Olomouc, CzechiaCzech Advanced Technology and Research Institute, Palacký University, Olomouc, CzechiaCzech Advanced Technology and Research Institute, Palacký University, Olomouc, CzechiaDepartment of Genetic Resources for Vegetables, Medicinal and Special Plants, Centre of the Region Haná for Biotechnological and Agricultural Research, Crop Research Institute, Olomouc, CzechiaCannabis Facility, Centre for Translational Medicine, International Clinical Research Centre, St. Anne’s University Hospital, Brno, CzechiaDepartment of Food Science, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Prague, CzechiaDepartment of Food Science, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Prague, CzechiaCzech Advanced Technology and Research Institute, Palacký University, Olomouc, CzechiaDepartment of Genetic Resources for Vegetables, Medicinal and Special Plants, Centre of the Region Haná for Biotechnological and Agricultural Research, Crop Research Institute, Olomouc, CzechiaAlthough medical cannabis was legalized in Czechia in 2013 and its use in topical treatments of skin disorders is now allowed, galenic formulations prepared from medical cannabis have not been widely implemented in the Czech healthcare system. One of the main reasons is the lack of a straightforward standardized protocol for their preparation. Cannabinoids, e.g., cannabidiol (CBD) and tetrahydrocannabinol (THC), have been shown to have therapeutic effects on various skin conditions, such as atopic dermatitis, psoriasis, scleroderma, acne and skin pigmentation. Recognizing the potential of dermatological treatment with medical cannabis, the present study aimed to evaluate the extraction capacity of various pharmaceutical bases for cannabinoids and the stability of prepared galenic formulations for dermatological applications with respect to cannabinoid content. The results showed that the stability of cannabinoids in formulations depended on the bases’ physical and chemical properties. The highest THC decomposition was observed in cream bases and Vaseline, with estimated percentage loss of total content of up to 5.4% and 5.6% per week, respectively. In contrast, CBD was more stable than THC. Overall, the tested bases were comparably effective in extracting cannabinoids from plant material. However, olive oil and Synderman bases exhibited the highest cannabinoid extraction efficiencies (approximately 70%) and the best storage stabilities in terms of the content of monitored compounds. The proposed preparation protocol is fast and easily implementable in pharmacies and medical facilities.https://www.frontiersin.org/articles/10.3389/fphar.2023.1230728/fullCannabis sativa L.medical cannabisphytocannabinoidgalenic preparationextractstability |
| spellingShingle | Dominika Kaczorová Dominika Kaczorová Dominika Kaczorová Jaroslav Peč Tibor Béres Nikola Štefelová Sanja Ćavar Zeljković Sanja Ćavar Zeljković Václav Trojan Anežka Kosmáková Janatová Pavel Klouček Petr Tarkowski Petr Tarkowski Phytocannabinoid-rich galenic preparations for topical administration: extraction and stability testing Frontiers in Pharmacology Cannabis sativa L. medical cannabis phytocannabinoid galenic preparation extract stability |
| title | Phytocannabinoid-rich galenic preparations for topical administration: extraction and stability testing |
| title_full | Phytocannabinoid-rich galenic preparations for topical administration: extraction and stability testing |
| title_fullStr | Phytocannabinoid-rich galenic preparations for topical administration: extraction and stability testing |
| title_full_unstemmed | Phytocannabinoid-rich galenic preparations for topical administration: extraction and stability testing |
| title_short | Phytocannabinoid-rich galenic preparations for topical administration: extraction and stability testing |
| title_sort | phytocannabinoid rich galenic preparations for topical administration extraction and stability testing |
| topic | Cannabis sativa L. medical cannabis phytocannabinoid galenic preparation extract stability |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1230728/full |
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