Cellular Retinoic Acid Binding Protein 2 Is Strikingly Downregulated in Human Esophageal Squamous Cell Carcinoma and Functions as a Tumor Suppressor.

Esophageal squamous cell carcinoma (ESCC) is the predominant pathotype of esophageal carcinoma (EC) in China, especially in Henan province, with poor prognosis and limited 5-year survival rate. Cellular retinoic acid binding protein 2 (CRABP2) is a member of the retinoic acid (RA) and lipocalin/cyto...

Full description

Bibliographic Details
Main Authors: Qingyuan Yang, Rui Wang, Weifan Xiao, Fenyong Sun, Hong Yuan, Qiuhui Pan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4739712?pdf=render
_version_ 1818505916368027648
author Qingyuan Yang
Rui Wang
Weifan Xiao
Fenyong Sun
Hong Yuan
Qiuhui Pan
author_facet Qingyuan Yang
Rui Wang
Weifan Xiao
Fenyong Sun
Hong Yuan
Qiuhui Pan
author_sort Qingyuan Yang
collection DOAJ
description Esophageal squamous cell carcinoma (ESCC) is the predominant pathotype of esophageal carcinoma (EC) in China, especially in Henan province, with poor prognosis and limited 5-year survival rate. Cellular retinoic acid binding protein 2 (CRABP2) is a member of the retinoic acid (RA) and lipocalin/cytosolic fatty-acid binding protein family and plays a completely contrary role in tumorigenesis through the retinoid signaling pathway, depending on the nuclear RA receptors (RAR) and PPARbeta/delta receptors. Presently, the biological role of CRABP2 in the development of ESCC has never been reported. Here, we firstly evaluated the expression of CRABP2 at both mRNA and protein levels and showed that it was remarkably downregulated in clinical ESCC tissues and closely correlated with the occurrence position, pathology, TNM stage, size, infiltration depth and cell differentiation of the tumor. Additionally, the biological function assays demonstrated that CRABP2 acted as a tumor suppressor in esophageal squamous carcinogenesis by significantly inhibiting cell growth, inducing cell apoptosis and blocking cell metastasis both in vitro and in vivo. All in all, our finding simplicate that CRABP2 is possibly an efficient molecular marker for diagnosing and predicting the development of ESCC.
first_indexed 2024-12-10T21:57:22Z
format Article
id doaj.art-4ce7a444e90f4a1cbbcce6a6db3472ce
institution Directory Open Access Journal
issn 1932-6203
language English
last_indexed 2024-12-10T21:57:22Z
publishDate 2016-01-01
publisher Public Library of Science (PLoS)
record_format Article
series PLoS ONE
spelling doaj.art-4ce7a444e90f4a1cbbcce6a6db3472ce2022-12-22T01:32:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01112e014838110.1371/journal.pone.0148381Cellular Retinoic Acid Binding Protein 2 Is Strikingly Downregulated in Human Esophageal Squamous Cell Carcinoma and Functions as a Tumor Suppressor.Qingyuan YangRui WangWeifan XiaoFenyong SunHong YuanQiuhui PanEsophageal squamous cell carcinoma (ESCC) is the predominant pathotype of esophageal carcinoma (EC) in China, especially in Henan province, with poor prognosis and limited 5-year survival rate. Cellular retinoic acid binding protein 2 (CRABP2) is a member of the retinoic acid (RA) and lipocalin/cytosolic fatty-acid binding protein family and plays a completely contrary role in tumorigenesis through the retinoid signaling pathway, depending on the nuclear RA receptors (RAR) and PPARbeta/delta receptors. Presently, the biological role of CRABP2 in the development of ESCC has never been reported. Here, we firstly evaluated the expression of CRABP2 at both mRNA and protein levels and showed that it was remarkably downregulated in clinical ESCC tissues and closely correlated with the occurrence position, pathology, TNM stage, size, infiltration depth and cell differentiation of the tumor. Additionally, the biological function assays demonstrated that CRABP2 acted as a tumor suppressor in esophageal squamous carcinogenesis by significantly inhibiting cell growth, inducing cell apoptosis and blocking cell metastasis both in vitro and in vivo. All in all, our finding simplicate that CRABP2 is possibly an efficient molecular marker for diagnosing and predicting the development of ESCC.http://europepmc.org/articles/PMC4739712?pdf=render
spellingShingle Qingyuan Yang
Rui Wang
Weifan Xiao
Fenyong Sun
Hong Yuan
Qiuhui Pan
Cellular Retinoic Acid Binding Protein 2 Is Strikingly Downregulated in Human Esophageal Squamous Cell Carcinoma and Functions as a Tumor Suppressor.
PLoS ONE
title Cellular Retinoic Acid Binding Protein 2 Is Strikingly Downregulated in Human Esophageal Squamous Cell Carcinoma and Functions as a Tumor Suppressor.
title_full Cellular Retinoic Acid Binding Protein 2 Is Strikingly Downregulated in Human Esophageal Squamous Cell Carcinoma and Functions as a Tumor Suppressor.
title_fullStr Cellular Retinoic Acid Binding Protein 2 Is Strikingly Downregulated in Human Esophageal Squamous Cell Carcinoma and Functions as a Tumor Suppressor.
title_full_unstemmed Cellular Retinoic Acid Binding Protein 2 Is Strikingly Downregulated in Human Esophageal Squamous Cell Carcinoma and Functions as a Tumor Suppressor.
title_short Cellular Retinoic Acid Binding Protein 2 Is Strikingly Downregulated in Human Esophageal Squamous Cell Carcinoma and Functions as a Tumor Suppressor.
title_sort cellular retinoic acid binding protein 2 is strikingly downregulated in human esophageal squamous cell carcinoma and functions as a tumor suppressor
url http://europepmc.org/articles/PMC4739712?pdf=render
work_keys_str_mv AT qingyuanyang cellularretinoicacidbindingprotein2isstrikinglydownregulatedinhumanesophagealsquamouscellcarcinomaandfunctionsasatumorsuppressor
AT ruiwang cellularretinoicacidbindingprotein2isstrikinglydownregulatedinhumanesophagealsquamouscellcarcinomaandfunctionsasatumorsuppressor
AT weifanxiao cellularretinoicacidbindingprotein2isstrikinglydownregulatedinhumanesophagealsquamouscellcarcinomaandfunctionsasatumorsuppressor
AT fenyongsun cellularretinoicacidbindingprotein2isstrikinglydownregulatedinhumanesophagealsquamouscellcarcinomaandfunctionsasatumorsuppressor
AT hongyuan cellularretinoicacidbindingprotein2isstrikinglydownregulatedinhumanesophagealsquamouscellcarcinomaandfunctionsasatumorsuppressor
AT qiuhuipan cellularretinoicacidbindingprotein2isstrikinglydownregulatedinhumanesophagealsquamouscellcarcinomaandfunctionsasatumorsuppressor