Antihyperuricemic, Anti-Inflammatory and Antihypertensive Effect of a Dry Extract from <i>Solidago virgaurea</i> L. (Asteraceae)
<i>Solidago virgaurea</i> L. is a perennial plant used in European traditional medicine as a diuretic or a remedy for inflammatory conditions of the urinary tract but also for gout, especially in the Balkans. The present study was focused on a preclinical, in vivo evaluation of antihyper...
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MDPI AG
2021-06-01
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| Series: | Scientia Pharmaceutica |
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| Online Access: | https://www.mdpi.com/2218-0532/89/2/27 |
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| author | Mircea Tămaş Oliviu Vostinaru Loredana Soran Ildiko Lung Ocsana Opris Anca Toiu Alexandru Gavan Elena Dinte Cristina Mogosan |
| author_facet | Mircea Tămaş Oliviu Vostinaru Loredana Soran Ildiko Lung Ocsana Opris Anca Toiu Alexandru Gavan Elena Dinte Cristina Mogosan |
| author_sort | Mircea Tămaş |
| collection | DOAJ |
| description | <i>Solidago virgaurea</i> L. is a perennial plant used in European traditional medicine as a diuretic or a remedy for inflammatory conditions of the urinary tract but also for gout, especially in the Balkans. The present study was focused on a preclinical, in vivo evaluation of antihyperuricemic, anti-inflammatory, and antihypertensive effects of a dry extract from <i>S. virgaurea</i> L. (ESV). Colorimetric and HPLC–MS techniques were used to identify the main chemical constituents of ESV. Antihyperuricemic effect of ESV was assessed in a rat model of hyperuricemia induced by the administration of potassium oxonate. Antihypertensive effect of ESV was evaluated in hyperuricemic rats by monitoring systolic blood pressure with a non-invasive blood-pressure recording system. The anti-inflammatory effect of ESV was tested using a rat model of paw edema. The main chemical constituents of ESV were rutin and phenolic acids represented by chlorogenic and caffeic acid. ESV demonstrated significant antihyperuricemic effects in rats due to an uricosuric mechanism. Additionally, ESV reduced the progression of arterial hypertension in hyperuricemic rats and also showed anti-inflammatory properties slightly inferior to diclofenac. The results suggest that ESV could be a natural remedy for the treatment of gout and protection against endothelial dysfunction caused by hyperuricemia. |
| first_indexed | 2024-03-10T10:25:19Z |
| format | Article |
| id | doaj.art-4ce7fed75857448f924624d8f3e7b5fe |
| institution | Directory Open Access Journal |
| issn | 0036-8709 2218-0532 |
| language | English |
| last_indexed | 2024-03-10T10:25:19Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Scientia Pharmaceutica |
| spelling | doaj.art-4ce7fed75857448f924624d8f3e7b5fe2023-11-22T00:03:56ZengMDPI AGScientia Pharmaceutica0036-87092218-05322021-06-018922710.3390/scipharm89020027Antihyperuricemic, Anti-Inflammatory and Antihypertensive Effect of a Dry Extract from <i>Solidago virgaurea</i> L. (Asteraceae)Mircea Tămaş0Oliviu Vostinaru1Loredana Soran2Ildiko Lung3Ocsana Opris4Anca Toiu5Alexandru Gavan6Elena Dinte7Cristina Mogosan8Department of Pharmaceutical Botany, Iuliu Hatieganu University of Medicine and Pharmacy, 23 Gh. Marinescu, 400337 Cluj-Napoca, RomaniaDepartment of Pharmacology, Physiology, Physiopathology, Iuliu Hatieganu University of Medicine and Pharmacy, 6A L. Pasteur, 400349 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath, 400293 Cluj-Napoca, RomaniaDepartment of Pharmacognosy, Iuliu Hatieganu University of Medicine and Pharmacy, 12 I. Creanga, 400010 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Technology and Biopharmaceutics, Iuliu Hatieganu University of Medicine and Pharmacy, 41 V. Babes, 400012 Cluj-Napoca, RomaniaDepartment of Pharmaceutical Technology and Biopharmaceutics, Iuliu Hatieganu University of Medicine and Pharmacy, 41 V. Babes, 400012 Cluj-Napoca, RomaniaDepartment of Pharmacology, Physiology, Physiopathology, Iuliu Hatieganu University of Medicine and Pharmacy, 6A L. Pasteur, 400349 Cluj-Napoca, Romania<i>Solidago virgaurea</i> L. is a perennial plant used in European traditional medicine as a diuretic or a remedy for inflammatory conditions of the urinary tract but also for gout, especially in the Balkans. The present study was focused on a preclinical, in vivo evaluation of antihyperuricemic, anti-inflammatory, and antihypertensive effects of a dry extract from <i>S. virgaurea</i> L. (ESV). Colorimetric and HPLC–MS techniques were used to identify the main chemical constituents of ESV. Antihyperuricemic effect of ESV was assessed in a rat model of hyperuricemia induced by the administration of potassium oxonate. Antihypertensive effect of ESV was evaluated in hyperuricemic rats by monitoring systolic blood pressure with a non-invasive blood-pressure recording system. The anti-inflammatory effect of ESV was tested using a rat model of paw edema. The main chemical constituents of ESV were rutin and phenolic acids represented by chlorogenic and caffeic acid. ESV demonstrated significant antihyperuricemic effects in rats due to an uricosuric mechanism. Additionally, ESV reduced the progression of arterial hypertension in hyperuricemic rats and also showed anti-inflammatory properties slightly inferior to diclofenac. The results suggest that ESV could be a natural remedy for the treatment of gout and protection against endothelial dysfunction caused by hyperuricemia.https://www.mdpi.com/2218-0532/89/2/27<i>Solidago virgaurea</i> L.antihyperuricemicanti-inflammatoryantihypertensive |
| spellingShingle | Mircea Tămaş Oliviu Vostinaru Loredana Soran Ildiko Lung Ocsana Opris Anca Toiu Alexandru Gavan Elena Dinte Cristina Mogosan Antihyperuricemic, Anti-Inflammatory and Antihypertensive Effect of a Dry Extract from <i>Solidago virgaurea</i> L. (Asteraceae) Scientia Pharmaceutica <i>Solidago virgaurea</i> L. antihyperuricemic anti-inflammatory antihypertensive |
| title | Antihyperuricemic, Anti-Inflammatory and Antihypertensive Effect of a Dry Extract from <i>Solidago virgaurea</i> L. (Asteraceae) |
| title_full | Antihyperuricemic, Anti-Inflammatory and Antihypertensive Effect of a Dry Extract from <i>Solidago virgaurea</i> L. (Asteraceae) |
| title_fullStr | Antihyperuricemic, Anti-Inflammatory and Antihypertensive Effect of a Dry Extract from <i>Solidago virgaurea</i> L. (Asteraceae) |
| title_full_unstemmed | Antihyperuricemic, Anti-Inflammatory and Antihypertensive Effect of a Dry Extract from <i>Solidago virgaurea</i> L. (Asteraceae) |
| title_short | Antihyperuricemic, Anti-Inflammatory and Antihypertensive Effect of a Dry Extract from <i>Solidago virgaurea</i> L. (Asteraceae) |
| title_sort | antihyperuricemic anti inflammatory and antihypertensive effect of a dry extract from i solidago virgaurea i l asteraceae |
| topic | <i>Solidago virgaurea</i> L. antihyperuricemic anti-inflammatory antihypertensive |
| url | https://www.mdpi.com/2218-0532/89/2/27 |
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