Antibody Neutralization of an Influenza Virus that Uses Neuraminidase for Receptor Binding

Antibody Neutralization of an Influenza Virus that Uses Neuraminidase for Receptor Binding

Influenza virus infection elicits antibodies against the receptor-binding protein hemagglutinin (HA) and the receptor-cleaving protein neuraminidase (NA). Because HA is essential for viral entry, antibodies targeting HA often potently neutralize the virus in single-cycle infection assays. However, a...

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Bibliographic Details
Main Authors: Lauren E. Gentles, Hongquan Wan, Maryna C. Eichelberger, Jesse D. Bloom
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Viruses
Subjects:
influenza virus
neuraminidase
neutralization
antibody escape
G147R
receptor-binding
Online Access:https://www.mdpi.com/1999-4915/12/6/597

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