Synthesis and Evaluation of Artificial Nucleic Acid Bearing an Oxanorbornane Scaffold

Synthesis and Evaluation of Artificial Nucleic Acid Bearing an Oxanorbornane Scaffold

Natural oligonucleotides have many rotatable single bonds, and thus their structures are inherently flexible. Structural flexibility leads to an entropic loss when unwound oligonucleotides form a duplex with single-stranded DNA or RNA. An effective approach to reduce such entropic loss in the duplex...

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Bibliographic Details
Main Authors: Hibiki Komine, Shohei Mori, Kunihiko Morihiro, Kenta Ishida, Takumi Okuda, Yuuya Kasahara, Hiroshi Aoyama, Takao Yamaguchi, Satoshi Obika
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
modified nucleic acid
modified oligonucleotide
oxanorbornane
conformational restriction
entropy
duplex-forming ability
Online Access:https://www.mdpi.com/1420-3049/25/7/1732

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